Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells

Journal of Ethnopharmacology

Volumn 120, Issue 2, 2008, Pages 129-137

  Cheng, Zhi Xiang ^a   Liu, Bao Rui ^a   Qian, Xiao Ping ^a   Ding, Yi Tao ^a   Hu, Wen Jing ^a   Sun, Jing ^a   Yu, Li Xia ^a  

^a Drum Tower Medical School of Nanjing Medical Univ and Clinical Cancer Inst of Nanjing Univ ^*  (China)

Author keywords

Mass spectrometry; Peptide fingerprinting; Rhizoma Paridis total saponin

Indexed keywords

CENTRIN 2; DEOXYRIBONUCLEASE GAMMA; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DIMETHYL SULFOXIDE; ENZYME; GUANINE MONOPHOSPHATE SYNTHETASE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; NUCLEOSIDE DIPHOSPHATE KINASE A; PLANT EXTRACT; PROTEIN; RHIZOMA PARIDIS EXTRACT; SAPONIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CHINA; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEDICINAL PLANT; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FINGERPRINTING; PROTEOMICS; RHIZOMA PARIDIS; TECHNIQUE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DISEASE PROGRESSION; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LILIACEAE; MEDICINE, CHINESE TRADITIONAL; PEPTIDE MAPPING; PROTEOMICS; RHIZOME; SAPONINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UP-REGULATION;

EID: 55149092516     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.07.030     Document Type: Article

References (47)

1. Achleitner E., Lui M.S., and Weber G. Inactivation by acivicin of rat brain CTP and GMP synthetases and depression of CTP and GTP concentrations. Advances in Enzyme Regulation 24 (1985) 225-232
2. Bosnar M.H., Bago R., Gall-Troselj K., Streichert T., and Pavelic J. Downstream targets of Nm23-H1: gene expression profiling of CAL 27 cells using DNA microarray. Molecular Carcinogenesis 45 (2006) 627-633
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1976) 248-254
4. Carpenter B., McKay M., Dundas S.R., Lawrie L.C., Telfer C., and Murray G.I. Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. British Journal of Cancer 95 (2006) 921-927
5. Chen C.X., Nagasawa J.Z.H., et al. Two minor steroidal saponins from the aerial parts of Paris polyphylla var. yunnanensis. Acta Botanica Yunnanica 17 (2001) 215-220
6. Cheung J.Y., Ong R.C., Suen Y.K., Ooi V., Wong H.N., Mak T.C., Fung K.P., Yu B., and Kong S.K. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells. Cancer Letters 217 (2005) 203-211
7. Evans J.R., Mitchell S.A., Spriggs K.A., Ostrowski J., Bomsztyk K., Ostarek D., and Willis A.E. Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo. Oncogene 22 (2003) 8012-8020
8. Harris J.M., McIntosh E.M., and Muscat G.E. Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target. Journal of Molecular Biology 288 (1999) 275-287
9. He Q.Y., Yip T.T., Li M., and Chiu J.F. Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology. Journal of Cellular Biochemistry 88 (2003) 1-8
10. Higami Y., Tsuchiya T., To K., Chiba T., Yamaza H., Shiokawa D., Tanuma S., and Shimokawa I. Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes. Cell and Tissue Research 316 (2004) 403-407
11. Huang C.S., Shih M.K., Chuang C.H., and Hu M.L. Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells. The Journal of Nutrition 135 (2005) 2119-2123
12. Ji, S., Zhou, T.S., Chang, C.J., 2001. Determination of anti-tumor cytotoxic active substance gracillin in Rhizoma Paridis and Yunnan White. Chinese Traditional Patent Medicine 23, 212-215.
13. Jin W.D., Chen X.P., and Cai H.J. In vitro cytotoxicity of Paridis extract on HepG2 cells. Acta Medical University Science Technology Hua zhong 35 (2006) 103-106
14. Jung S., Paek Y.W., Moon K.S., Wee S.C., Ryu H.H., Jeong Y.I., Sun H.S., Jin Y.H., Kim K.K., and Ahn K.Y. Expression of Nm23 in gliomas and its effect on migration and invasion in vitro. Anticancer Research 26 (2006) 249-258
15. Klimek-Tomczak K., Mikula M., Dzwonek A., Paziewska A., Karczmarski J., Hennig E., Bujnicki J.M., Bragoszewski P., Denisenko O., Bomsztyk K., and Ostrowski J. Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa. British Journal of Cancer 94 (2006) 586-592
16. Koehler S.E., and Ladner R.D. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Molecular Pharmacology 66 (2004) 620-626
17. Ladner R.D., Lynch F.J., Groshen S., Xiong Y.P., Sherrod A., Caradonna S.J., Stoehlmacher J., and Lenz H.J. dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. Cancer Research 60 (2000) 3493-3503
18. Lee M.S., Yuet-Wa J.C., Kong S.K., Yu B., Eng-Choon V.O., Nai-Ching H.W., Chung-Wai T.M., and Fung K.P. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biology & Therapy 4 (2005) 1248-1254
19. Li H. The phylogeny of the genus Paris. Acta Botanica Yunnanica 6 (1984) 351-362
20. Li, H., 1998. The Genus Paris (Trilliaceae). Science Press, Beijing, pp. 193-194.
21. Li J., Zhou J., Chen G., Wang H., Wang S., Xing H., Gao Q., Lu Y., He Y., and Ma D. Inhibition of ovarian cancer metastasis by adeno-associated virus-mediated gene transfer of nm23H1 in an orthotopic implantation model. Cancer Gene Therapy 13 (2006) 266-272
22. Lou L., Nakamura J., Tsing S., Nguyen B., Chow J., Straub K., Chan H., and Barnett J. High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase. Protein Expression and Purification 6 (1995) 487-495
23. Lui M.S., Kizaki H., and Weber G. Biochemical pharmacology of acivicin in rat hepatoma cells. Biochemical Pharmacology 31 (1982) 3469-3473
24. Matsuda H., Pongpiriyadacha Y., Morikawa T., Kishi A., Kataoka S., and Yoshikawa M. Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action. Bioorganic & Medicinal Chemistry Letters 13 (2003) 1101-1106
25. Michelotti E.F., Tomonaga T., Krutzsch H., and Levens D. Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene. The Journal of Biological Chemistry 270 (1995) 9494-9499
26. Michelotti E.F., Michelotti G.A., Aronsohn A.I., and Levens D. Heterogeneous nuclear ribonucleoprotein K is a transcription factor. Molecular and Cellular Biology 16 (1996) 2350-2360
27. Mizuta R., Mizuta M., Araki S., Shiokawa D., Tanuma S., and Kitamura D. Action of apoptotic endonuclease DNase gamma on naked DNA and chromatin substrates. Biochemical and Biophysical Research Communications 345 (2006) 560-567
28. Nakamura J., and Lou L. Biochemical characterization of human GMP synthetase. The Journal of Biological Chemistry 270 (1995) 7347-7353
29. Natsumeda Y., Ikegami T., Olah E., and Weber G. Significance of purine salvage in circumventing the action of antimetabolites in rat hepatoma cells. Cancer Research 49 (1989) 88-92
30. Ostrowski J., Wyrwicz L., Rychlewski L., and Bomsztyk K. Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle. The Journal of Biological Chemistry 277 (2002) 6303-6310
31. Padmanabhan B., Kuzuhara T., Mizuno H., and Horikoshi M. Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B. Acta Crystallographica D Biological Crystallographica 56 (2000) 1479-1481
32. Palmieri D., Halverson D.O., Ouatas T., Horak C.E., Salerno M., Johnson J., Figg W.D., Hollingshead M., Hursting S., Berrigan D., Steinberg S.M., Merino M.J., and Steeg P.S. Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer. Journal of the National Cancer Institute 97 (2005) 632-642
33. Parkin D.M., Bray F., Ferlay J., and Pisani P. Estimating the world cancer burden: Globocan 2000. International Journal of Cancer 94 (2001) 153-156
34. Saito R., Mizuno M., Kumabe T., Yoshimoto T., Tanuma S., and Yoshida J. Apoptotic DNA endonuclease (DNase-gamma) gene transfer induces cell death accompanying DNA fragmentation in human glioma cells. Journal of Neuro-Oncology 63 (2003) 25-31
35. Schatten C. The centrosome and its mode of inheritance: the reduction of the centrosome during gametogenesis and its restoration during fertilization. Developmental Biology 165 (1994) 299
36. Sheu J.C. Molecular mechanism of hepatocarcinogenesis. Journal of Gastroenterology and Hepatology 12 (1997) S309-S313
37. Shevchenko A., Wilm M., Vorm O., and Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Analytical Chemistry 68 (1996) 850-858
38. Shiokawa D., and Tanuma S. Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. Biochemistry 40 (2001) 143-152
39. Shiokawa D., Kobayashi T., and Tanuma S. Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells. The Journal of Biological Chemistry 277 (2002) 31031-31037
40. Sun J., Liu B.R., Hu W.J., Yu L.X., and Qian X.P. In vitro anticancer activity of aqueous extracts and ethanol extracts of fifteen traditional Chinese medicines on human digestive tumor cell lines. Phytotherapy Research 21 (2007) 1102-1104
41. Sunaga S., Yoshimori A., Shiokawa D., and Tanuma S. Structure basis for the inhibitory mechanism of a novel DNase gamma-specific inhibitor, DR396. Bioorganic & Medicinal Chemistry 14 (2006) 4217-4226
42. Tee Y.T., Chen G.D., Lin L.Y., Ko J.L., and Wang P.H. Nm23-H1: a metastasis-associated gene. Taiwanese Journal of Obstetrics & Gynecology 45 (2006) 107-113
43. Thiede B., Dimmler C., Siejak F., and Rudel T. Predominant identification of RNA-binding proteins in Fas-induced apoptosis by proteome analysis. The Journal of Biological Chemistry 276 (2001) 26044-26050
44. Thomas M.B., and Zhu A.X. Hepatocellular carcinoma: the need for progress. Journal of Clinical Oncology 23 (2005) 2892-2899
45. Wang Q., Xu G., and Jiang Y. Analgesic and sedative effects of the Chinese drug rhizoma Paridis. Zhongguo Zhong Yao Za Zhi 15 (1990) 128
46. Wang, S.L., Zhao, Y.L., Li, X.Y., et al., 1996. Study on amyloid and colloidal Paris polyphylla var. yunnanensis. Acta Botanica Yunnanica 18, 345-348.
47. Wolfrum U., and Salisbury J.L. Expression of centrin isoforms in the mammalian retina. Experimental Cell Research 242 (1998) 10-17