The amygdala in post-traumatic stress disorder

Post-Traumatic Stress Disorder: Basic Science and Clinical Practice

Volumn , Issue , 2009, Pages 319-334

  Shin, Lisa M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Amygdala; anterior cingulate cortex; fear conditioning; medial prefrontal cortex; neuroimaging

Indexed keywords

EID: 84866853779     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-60327-329-9_15     Document Type: Chapter

References (107)

1. Davis, M. Whalen" P. J., and (2001) The amygdala: vigilance and emotion. Mol Psychiatry 6, 13-34.
2. LeDoux, J. E. (2000) Emotion circuits in the brain. Annu Rev Neurosci 23, 155-84.
3. Whalen, P. J. (1998) Fear, vigilance, and ambiguity: initial neuroimaging studies of the human amygdala. Curr Direct Psychol Sci 6, 178-88.
4. Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., and Rosen, B. R. (1996) Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17, 875-87.
5. Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., and Dolan, R. J. (1996) A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 383, 812-15.
6. Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., and Jenike, M. A. (1998) Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 18, 411-18.
7. Irwin, W., Davidson, R. J., Lowe, M. J., Mock, B. J., Sorenson, J. A., and Turski, P. A. (1996) Human amygdala activation detected with echo-planar functional magnetic resonance imaging. Neuroreport 7, 1765-69.
8. Reiman, E. M., Lane, R. D., Ahern, G. L., Schwartz, G. E., Davidson, R. J., Friston, K. J., Yun, L. S., and Chen, K. (1997) Neuroanatomical correlates of externally and internally generated human emotion. Am J Psychiatry 154, 918-25.
9. Buchel, C., Morris, J., Dolan, R. J., and Friston, K. J. (1998) Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron 20, 947-57.
10. Buchel, C., Dolan, R. J., Armony, J. L., and Friston, K. J. (1999) Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci 19, 10869-76.
11. LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., and Phelps, E. A. (1998) Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron 20, 937-45.
12. Cahill, L., Haier, R. J., Fallon, J., Alkire, M. T., Tang, C., Keator, D., Wu, J., and McGaugh, J. L. (1996) Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proc Natl Acad Sci U S A 93, 8016-21.
13. Hamann, S. B., Ely, T. D., Grafton, S. T., and Kilts, C. D. (1999) Amygdala activity related to enhanced memory for pleasant and aversive stimuli. Nat Neurosci 2, 289-93.
14. Dolcos, F., LaBar, K. S., and Cabeza, R. (2004) Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events. Neuron 42, 855-63.
15. Dolcos, F., LaBar, K. S., and Cabeza, R. (2005) Remembering one year later: role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories. Proc Natl Acad Sci U S A 102, 2626-31.
16. Elzinga, B. M., and Bremner, J. D. (2002) Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)? J Affect Disord 70, 1-17.
17. Francati, V., Vermetten, E., and Bremner, J. D. (2007) Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings. Depress Anxiety 24, 202-18.
18. Hamner, M. B., Lorberbaum, J. P., and George, M. S. (1999) Potential role of the anterior cingulate cortex in PTSD: review and hypothesis. Depress Anxiety 9, 1-14.
19. Layton, B., and Krikorian, R. (2002) Memory mechanisms in posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci 14, 254-61.
20. Rauch, S. L., Shin, L. M., Whalen, P. J., and Pitman, R. K. (1998) Neuroimaging and the neuroanatomy of PTSD. CNS Spectrums 3 (suppl. 2), 30-41.
21. Liberzon, I., Taylor, S. F., Amdur, R., Jung, T. D., Chamberlain, K. R., Minoshima, S., Koeppe, R. A., and Fig, L. M. (1999) Brain activation in PTSD in response to traumarelated stimuli. Biol Psychiatry 45, 817-26.
22. Pissiota, A., Frans, O., Fernandez, M., von Knorring, L., Fischer, H., and Fredrikson, M. (2002) Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study. Eur Arch Psychiatry Clin Neurosci 252, 68-75.
23. Vermetten, E., Schmahl, C., Southwick, S. M., and Bremner, J. D. (2007) Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder. Psychopharmacol Bull 40, 8-30.
24. Shin, L. M., Kosslyn, S. M., McNally, R. J., Alpert, N. M., Thompson, W. L., Rauch, S. L., Macklin, M. L., and Pitman, R. K. (1997) Visual imagery and perception in posttraumatic stress disorder. A positron emission tomographic investigation. Arch Gen Psychiatry 54, 233-41.
25. Hendler, T., Rotshtein, P., Yeshurun, Y., Weizmann, T., Kahn, I., Ben-Bashat, D., Malach, R., and Bleich, A. (2003) Sensing the invisible: differential sensitivity of visual cortex and amygdala to traumatic context. Neuroimage 19, 587-600.
26. Protopopescu, X., Pan, H., Tuescher, O., Cloitre, M., Goldstein, M., Engelien, W., Epstein, J., Yang, Y., Gorman, J., Ledoux, J., Silbersweig, D., and Stern, E. (2005) Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biol Psychiatry 57, 464-73.
27. Rauch, S. L., van der Kolk, B. A., Fisler, R. E., Alpert, N. M., Orr, S. P., Savage, C. R., Fischman, A. J., Jenike, M. A., and Pitman, R. K. (1996) A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry 53, 380-87.
28. Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., Marzol Peters, P., Metzger, L., Dougherty, D. D., Cannistraro, P. A., Alpert, N. M., Fischman, A. J., and Pitman, R. K. (2004) Regional cerebral blood flow in amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry 61, 168-76.
29. Driessen, M., Beblo, T., Mertens, M., Piefke, M., Rullkoetter, N., Silva-Saavedra, A., Reddemann, L., Rau, H., Markowitsch, H.J., Wulff, H., Lange, W., and Woermann, F. G. (2004) Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. Biol Psychiatry 55, 603-11.
30. Bremner, J. D., Narayan, M., Staib, L. H., Southwick, S. M., McGlashan, T., and Charney, D. S. (1999) Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156, 1787-95.
31. Bremner, J. D., Staib, L. H., Kaloupek, D., Southwick, S. M., Soufer, R., and Charney, D. S. (1999) Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biol Psychiatry 45, 806-16.
32. Britton, J. C., Phan, K. L., Taylor, S. F., Fig, L. M., and Liberzon, I. (2005) Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery. Biol Psychiatry 57, 832-40.
33. Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., and Menon, R. S. (2001) Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation. Am J Psychiatry 158, 1920-22.
34. Lanius, R., Williamson, P., Boksman, K., Densmore, M., Gupta, M., Neufeld, R., Gati, J., and Menon, R. (2002) Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation. Biol Psychiatry 52, 305.
35. Shin, L. M., McNally, R. J., Kosslyn, S. M., Thompson, W. L., Rauch, S. L., Alpert, N. M., Metzger, L. J., Lasko, N. B., Orr, S. P., and Pitman, R. K. (1999) Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. Am J Psychiatry 156, 575-84.
36. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., and Weinberger, D. R. (2005) A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62, 146-52.
37. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., and Weinberger, D. R. (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8, 828-34.
38. Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P., and Pitman, R. K. (2000) Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry 47, 769-76.
39. Armony, J. L., Corbo, V., Clement, M. H., and Brunet, A. (2005) Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions. Am J Psychiatry 162, 1961-63.
40. Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., Orr, S. P., Pitman, R. K., Whalen, P. J., and Rauch, S. L. (2005) A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 62, 273-81.
41. Williams, L. M., Kemp, A. H., Felmingham, K., Barton, M., Olivieri, G., Peduto, A., Gordon, E., and Bryant, R. A. (2006) Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage 29, 347-57.
42. Phan, K. L., Britton, J. C., Taylor, S. F., Fig, L. M., and Liberzon, I. (2006) Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Arch Gen Psychiatry 63, 184-92.
43. Felmingham, K., Kemp, A., Williams, L., Das, P., Hughes, G., Peduto, A., and Bryant, R. (2007) Changes in anterior cingulate and amygdala after cognitive behavior therapy of posttraumatic stress disorder. Psychol Sci 18, 127-29.
44. Bryant, R. A., Felmingham, K., Kemp, A., Das, P., Hughes, G., Peduto, A., and Williams, L. (2008) Amygdala and ventral anterior cingulate activation predicts treatment response to cognitive behaviour therapy for post-traumatic stress disorder. Psychol Med, 38, 555-61.
45. Orr, S. P., Metzger, L. J., Lasko, N. B., Macklin, M. L., Peri, T., and Pitman, R. K. (2000) De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol 109, 290-98.
46. Peri, T., Ben-Shakhar, G., Orr, S. P., and Shalev, A.Y. (2000) Psychophysiologic assessment of aversive conditioning in posttraumatic stress disorder. Biol Psychiatry 47, 512-19.
47. Rauch, S. L., Shin, L. M., and Phelps, E. A. (2006) Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research - past, present, and future. Biol Psychiatry 60, 376-82.
48. Bremner, J. D., Vermetten, E., Schmahl, C., Vaccarino, V., Vythilingam, M., Afzal, N., Grillon, C., and Charney, D. S. (2005) Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychol Med 35, 791-806.
49. Semple, W. E., Goyer, P. F., McCormick, R., Donovan, B., Muzic, R.F., Jr., Rugle, L., McCutcheon, K., Lewis, C., Liebling, D., Kowaliw, S., Vapenik, K., Semple, M. A., Flener, C. R., and Schulz, S. C. (2000) Higher brain blood flow at amygdala and lower frontal cortex blood flow in PTSD patients with comorbid cocaine and alcohol abuse compared with normals. Psychiatry 63, 65-74.
50. Bryant, R. A., Felmingham, K. L., Kemp, A. H., Barton, M., Peduto, A. S., Rennie, C., Gordon, E., and Williams, L. M. (2005) Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study. Biol Psychiatry 58, 111-18.
51. Chung, Y. A., Kim, S. H., Chung, S. K., Chae, J. H., Yang, D. W., Sohn, H. S., and Jeong, J. (2006) Alterations in cerebral perfusion in posttraumatic stress disorder patients without re-exposure to accident-related stimuli. Clin Neurophysiol 117, 637-42.
52. Bonne, O., Gilboa, A., Louzoun, Y., Brandes, D., Yona, I., Lester, H., Barkai, G., Freedman, N., Chisin, R., and Shalev, A. Y. (2003) Resting regional cerebral perfusion in recent posttraumatic stress disorder. Biol Psychiatry 54, 1077-86.
53. Mirzaei, S., Knoll, P., Keck, A., Preitler, B., Gutierrez, E., Umek, H., Kohn, H., and Pecherstorfer, M. (2001) Regional cerebral blood flow in patients suffering from posttraumatic stress disorder. Neuropsychobiology 43, 260-4.
54. Pavic, L., Gregurek, R., Petrovic, R., Petrovic, D., Varda, R., Vukusic, H., and Crnkovic-Markovic, S. (2003) Alterations in brain activation in posttraumatic stress disorder patients with severe hyperarousal symptoms and impulsive aggressiveness. Eur Arch Psychiatry Clin Neurosci 253, 80-83.
55. Sachinvala, N., Kling, A., Suffin, S., Lake, R., and Cohen, M. (2000) Increased regional cerebral perfusion by 99mTc hexamethyl propylene amine oxime single photon emission computed tomography in post-traumatic stress disorder. Mil Med 165, 473-79.
56. Matsuoka, Y., Yamawaki, S., Inagaki, M., Akechi, T., and Uchitomi, Y. (2003) A volumetric study of amygdala in cancer survivors with intrusive recollections. Biol Psychiatry 54, 736-43.
57. Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., and Charney, D. S. (1997) Magnetic resonance imagingbased measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse - a preliminary report. Biol Psychiatry 41, 23-32.
58. Wignall, E. L., Dickson, J. M., Vaughan, P., Farrow, T. F., Wilkinson, I. D., Hunter, M. D., and Woodruff, P. W. (2004) Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder. Biol Psychiatry 56, 832-36.
59. Karl, A., Schaefer, M., Malta, L. S., Dorfel, D., Rohleder, N., and Werner, A. (2006) A metaanalysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 30, 1004-31.
60. Bonne, O., Brandes, D., Gilboa, A., Gomori, J. M., Shenton, M. E., Pitman, R. K., and Shalev, A. Y. (2001) Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am J Psychiatry 158, 1248-51.
61. De Bellis, M. D., Hall, J., Boring, A. M., Frustaci, K., and Moritz, G. (2001) A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 50, 305-9.
62. De Bellis, M. D., Keshavan, M. S., Shifflett, H., Iyengar, S., Beers, S. R., Hall, J., and Moritz, G. (2002) Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biol Psychiatry 52, 1066-78.
63. Fennema-Notestine, C., Stein, M. B., Kennedy, C. M., Archibald, S. L., and Jernigan, T. L. (2002) Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder. Biol Psychiatry 52, 1089-101.
64. Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., and Pitman, R. K. (2002) Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 5, 1242-47.
65. Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., Orr, S. P., Kikinis, R., Jolesz, F. A., McCarley, R. W., and Pitman, R. K. (1996) Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry 40, 1091-99.
66. Lindauer, R. J., Vlieger, E. J., Jalink, M., Olff, M., Carlier, I. V., Majoie, C. B., den Heeten, G. J., and Gersons, B. P. (2004) Smaller hippocampal volume in Dutch police officers with posttraumatic stress disorder. Biol Psychiatry 56, 356-63.
67. Liberzon, I., Taylor, S. F., Phan, K. L., Britton, J. C., Fig, L. M., Bueller, J. A., Koeppe, R. A., and Zubieta, J. K. (2007) Altered central micro-opioid receptor binding after psychological trauma. Biol Psychiatry 61, 1030-38.
68. Aggleton, J. P., Burton, M. J., and Passingham, R. E. (1980) Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta). Brain Res 190, 347-68.
69. Chiba, T., Kayahara, T., and Nakano, K. (2001) Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata. Brain Res 888, 83-101.
70. Ghashghaei, H. T., and Barbas, H. (2002) Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience 115, 1261-79.
71. Bush, G., Luu, P., and Posner, M. I. (2000) Cognitive and emotional influence in anterior cingulate cortex. Trends Cogn Sci 4, 215-22.
72. Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., and Fox, P. T. (1997) Cingulate function in depression: a potential predictor of treatment response. Neuroreport 8, 1057-61.
73. Mayberg, H. S. (1997) Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 9, 471-81.
74. Whalen, P. J., Bush, G., McNally, R. J., Wilhelm, S., McInerney, S. C., Jenike, M. A., and Rauch, S. L. (1998) The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division. Biol Psychiatry 44, 1219-28.
75. Milad, M. R., and Quirk, G. J. (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420, 70-74.
76. Milad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., and Rauch, S. L. (2007) Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry 62, 446-54.
77. Morgan, M. A., Romanski, L. M., and LeDoux, J. E. (1993) Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci Lett 163, 109-13.
78. Phelps, E. A., Delgado, M. R., Nearing, K. I., and LeDoux, J. E. (2004) Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43, 897-905.
79. Quirk, G. J., Russo, G. K., Barron, J. L., and Lebron, K. (2000) The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci 20, 6225-31.
80. Lindauer, R. J., Booij, J., Habraken, J. B., Uylings, H. B., Olff, M., Carlier, I. V., den Heeten, G. J., van Eck-Smit, B. L., and Gersons, B. P. (2004) Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder. Biol Psychiatry 56, 853-61.
81. Hou, C., Liu, J., Wang, K., Li, L., Liang, M., He, Z., Liu, Y., Zhang, Y., Li, W., and Jiang, T. (2007) Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD. Brain Res 1144, 165-74.
82. Yang, P., Wu, M. T., Hsu, C. C., and Ker, J. H. (2004) Evidence of early neurobiological alternations in adolescents with posttraumatic stress disorder: a functional MRI study. Neurosci Lett 370, 13-18.
83. Lanius, R. A., Williamson, P. C., Hopper, J., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., and Menon, R. S. (2003) Recall of emotional states in posttraumatic stress disorder: an fMRI investigation. Biol Psychiatry 53, 204-10.
84. Kim, M. J., Chey, J., Chung, A., Bae, S., Khang, H., Ham, B., Yoon, S. J., Jeong, D. U., and Lyoo, I. K. (2008) Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder. J Psychiatr Res 42, 268-77.
85. Bremner, J. D., Vermetten, E., Vythilingam, M., Afzal, N., Schmahl, C., Elzinga, B., and Charney, D. S. (2004) Neural correlates of the classic color and emotional Stroop in women with abuse-related posttraumatic stress disorder. Biol Psychiatry 55, 612-20.
86. Shin, L. M., Whalen, P.J., Pitman, R. K., Bush, G., Macklin, M. L., Lasko, N. B., Orr, S. P., McInerney, S. C., and Rauch, S. L. (2001) An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biol Psychiatry 50, 932-42.
87. Bremner, J. D., Vythilingam, M., Vermetten, E., Southwick, S. M., McGlashan, T., Staib, L. H., Soufer, R., and Charney, D. S. (2003) Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biol Psychiatry 53, 879-89.
88. Hopper, J. W., Frewen, P. A., van der Kolk, B. A., and Lanius, R. A. (2007) Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery. J Trauma Stress 20, 713-25.
89. Seedat, S., Warwick, J., van Heerden, B., Hugo, C., Zungu-Dirwayi, N., Van Kradenburg, J., and Stein, D. J. (2004) Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor. J Affect Disord 80, 45-53.
90. Shin, L. M., Bush, G., Whalen, P. J., Handwerger, K., Cannistraro, P. A., Wright, C. I., Martis, B., Macklin, M. L., Lasko, N. B., Orr, S. P., Pitman, R. K., and Rauch, S. L. (2007) Dorsal anterior cingulate function in posttraumatic stress disorder. J Trauma Stress 20, 701-12.
91. Etkin, A., and Wager, T. D. (2007) Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 164, 1476-88.
92. Gilboa, A., Shalev, A. Y., Laor, L., Lester, H., Louzoun, Y., Chisin, R., and Bonne, O. (2004) Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder. Biol Psychiatry 55, 263-72.
93. Rauch, S. L., Shin, L. M., Segal, E., Pitman, R. K., Carson, M. A., McMullin, K., Whalen, P. J., and Makris, N. (2003) Selectively reduced regional cortical volumes in post-traumatic stress disorder. Neuroreport 14, 913-16.
94. Woodward, S. H., Kaloupek, D. G., Streeter, C. C., Martinez, C., Schaer, M., and Eliez, S. (2006) Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry 59, 582-87.
95. Corbo, V., Clement, M. H., Armony, J. L., Pruessner, J. C., and Brunet, A. (2005) Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biol Psychiatry 58, 119-24.
96. Kasai, K., Yamasue, H., Gilbertson, M. W., Shenton, M. E., Rauch, S. L., and Pitman, R. K. (2008) Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biol Psychiatry 63, 550-56.
97. Yamasue, H., Kasai, K., Iwanami, A., Ohtani, T., Yamada, H., Abe, O., Kuroki, N., Fukuda, R., Tochigi, M., Furukawa, S., Sadamatsu, M., Sasaki, T., Aoki, S., Ohtomo, K., Asukai, N., and Kato, N. (2003) Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proc Natl Acad Sci U S A 100, 9039-43.
98. De Bellis, M. D., Keshavan, M. S., Spencer, S., and Hall, J. (2000) N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD. Am J Psychiatry 157, 1175-77.
99. De Bellis, M. D., Keshavan, M. S., and Harenski, K. A. (2001) Anterior cingulate N-acetylaspartate/creatine ratios during clonidine treatment in a maltreated child with posttraumatic stress disorder. J Child Adolesc Psychopharmacol 11, 311-16.
100. Ham, B. J., Chey, J., Yoon, S. J., Sung, Y., Jeong, D. U., Ju Kim, S., Sim, M. E., Choi, N., Choi, I. G., Renshaw, P. F., and Lyoo, I. K. (2007) Decreased N-acetyl-aspartate levels in anterior cingulate and hippocampus in subjects with post-traumatic stress disorder: a proton magnetic resonance spectroscopy study. Eur J Neurosci 25, 324-29.
101. Mahmutyazicioglu, K., Konuk, N., Ozdemir, H., Atasoy, N., Atik, L., and Gundogdu, S. (2005) Evaluation of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder. Diagn Interv Radiol 11, 125-29.
102. Schuff, N., Neylan, T. C., Fox-Bosetti, S., Lenoci, M., Samuelson, K. W., Studholme, C., Kornak, J., Marmar, C. R., and Weiner, M. W. (2008) Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. Psychiatry Res 162, 147-57.
103. Koenigs, M., Huey, E. D., Raymont, V., Cheon, B., Solomon, J., Wassermann, E. M., and Grafman, J. (2008) Focal brain damage protects against post-traumatic stress disorder in combat veterans. Nat Neurosci 11, 232-37.
104. Ganzel, B., Casey, B. J., Glover, G., Voss, H. U., Temple, E. (2007) The aftermath of 9/11: effect of intensity and recency of trauma on outcome. Emotion 7, 227-38.
105. Whalen, P. J., Shin, L. M., Mcinerney, S. C., Fischer, H., Wright, C. I., and Rauch, S. L. (2001) A functional MRI study of human amygdala responses to facial expressions of fear versus anger. Emotion 1, 70-83.
106. Kemp, A. H., Felmingham, K., Das, P., Hughes, G., Peduto, A. S., Bryant, R. A., and Williams, L. M. (2007) Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study. Psychiatry Res 155, 265-69.
107. Lanius, R. A., Frewen, P. A., Girotti, M., Neufeld, R. W., Stevens, T. K., and Densmore, M. (2007) Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigation. Psychiatry Res 155, 45-56.