Functional neuroimaging studies in posttraumatic stress disorder: Review of current methods and findings

Depression and Anxiety

Volumn 24, Issue 3, 2007, Pages 202-218

  Francati, V ^a,b   Vermetten, E ^b,c   Bremner, J D ^a,d,e  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c CENTRAL MILITARY HOSPITAL   (Netherlands)

^d Ctr Positron Emission Tomography   (United States)

^e ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Amygdala; fMRI; Hippocampus; Imaging; PET; Prefrontal cortex; PTSD; SPECT

Indexed keywords

CARBON 11; FLUORINE 18; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; IOMAZENIL; NITROGEN 13; OXYGEN 15; SODIUM IODIDE;

BEHAVIOR; BRAIN BLOOD FLOW; BRAIN METABOLISM; FEAR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MEMORY DISORDER; NERVE CELL NETWORK; NERVE CONDUCTION; NEUROANATOMY; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REVIEW; SENSITIZATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRESS;

AMYGDALA; BRAIN; CEREBROVASCULAR CIRCULATION; FEAR; HUMANS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; STRESS DISORDERS, POST-TRAUMATIC; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 34249106372     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.20208     Document Type: Review

References (79)

1. Bonne O, Bain E, Neumeister A, Nugent AC, Vythilingam M, Carson RE, Luckenbaugh DA, Eckelman W, Herscovitch P, Drevets WC, et al. 2005. No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder. Am J Psychiatry 162:383-385.
2. Bonne O, Brandes D, Gilboa A, Gomori JM, Shenton ME, Pitman RK, Shalev AY. 2001. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am J Psychiatry 158: 1248-1251.
3. Bonne O, Brandes D, Segman R, Pitman RK, Yehuda R, Shalev AY. 2003a. Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder. Psychiatry Res 119:171-175.
4. Bonne O, Gilboa A, Louzoun Y, Brandes D, Yona I, Lester H, Barkai G, Freedman N, Chisin R, Shalev AY. 2003b. Resting regional cerebral perfusion in recent posttraumatic stress disorder. Biol Psychiatry 54:1077-1086.
5. Bremner JD. 2002. Does stress damage the brain. New York: Norton.
6. Bremner JD. 2003. Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with data. Psychopharmacol Bull 37:6-25.
7. Bremner JD. 2005. Brain imaging handbook. New York: Norton. 195p.
8. Bremner JD, Charney, DS. 1994. Neurobiology of posttraumatic stress disorder: Implications for treatment. In: Darcourt G, Mendlewicz J, Racagni G, Brunello N, editors. Current therapeutic approaches to panic and other anxiety disorders. Int Acad Biomed Drug Res 8:171-186.
9. Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. 1997. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry 54:246-254.
10. Bremner JD, Innis RB, Southwick SM, Staib L, Zoghbi S, Charney DS. 2000. Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. Am J Psychiatry 157:1120-1126.
11. Bremner JD, Krystal JH, Southwick SM, Charney DS. 1995a. Functional neuroanatomical correlates of the effects of stress on memory. J Trauma Stress 8:527-553.
12. Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS. 1999a. Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156:1787-1795.
13. Bremner JD, Randall P, Scott TM, Capelli S, Delaney R, McCarthy G, Charney DS. 1995b. Deficits in short-term memory in adult survivors of childhood abuse. Psychiatry Res 59: 97-107.
14. Bremner JD, Scott TM, Delaney RC, Southwick SM, Mason JW, Johnson DR, Innis RB, McCarthy G, Charney DS. 1993. Deficits in short-term memory in posttraumatic stress disorder. Am J Psychiatry 150:1015-1019.
15. Bremner JD, Staib LH, Kaloupek D, Southwick SM, Soufer R, Charney DS. 1999b. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study. Biol Psychiatry 45:806-816.
16. Bremner JD, Vermetten E, Schmahl C, Vaccarino V, Vythilingam M, Afzal N, Grillon C, Charney DS. 2005. Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychol Med 35: 791-806.
17. Bremner JD, Vermetten E, Vythilingam M, Afzal N, Schmahl C, Elzinga B, Charney DS. 2004. Neural correlates of the classic color and emotional Stroop in women with abuse-related posttraumatic stress disorder. Biol Psychiatry 55:612-620.
18. Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. 2003a. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. Am J Psychiatry 160:924-932.
19. Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. 2003b. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biol Psychiatry 53:879-889.
20. Britton JC, Phan KL, Taylor SF, Fig LM, Liberzon I. 2005. Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery. Biol Psychiatry 57:832-840.
21. Charney DS. 2004. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry 161:195-216.
22. Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. 1993. Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry 50:295-305.
23. Driessen M, Beblo T, Mertens M, Piefke M, Rullkoetter N, Silva-Saavedra A, Reddemann L, Rau H, Markowitsch HJ, Wulff H, Lange W, Woermann FG. 2004. Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder. Biol Psychiatry 55: 603-611.
24. Fujita M, Southwick SM, Denucci CC, Zoghbi SS, Dillon MS, Baldwin RM, Bozkurt A, Kugaya A, Verhoeff NP, Seibyl JP, Innis RB. 2004. Central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorder. Biol Psychiatry 56:95-100.
25. Geuze E, Vermetten E, Bremner JD. 2005. MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders. Mol Psychiatry 10:160-184.
26. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, Pitman RK. 2002. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 5:1242-1247.
27. Gilboa A, Shalev AY, Laor L, Lester H, Louzoun Y, Chisin R, Bonne O. 2004. Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder. Biol Psychiatry 55: 263-272.
28. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS Jr, Faraone SV, Tsuang MT. 2001. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 11:490-497.
29. Groch MW, Erwin WD. 2000. SPECT in the year 2000: Basic principles. J Nucl Med Technol 28:233-244.
30. Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A. 2003. Sensing the invisible: Differential sensitivity of visual cortex and amygdala to traumatic context. Neuroimage 19:587-600.
31. Jueptner M, Weiller C. 1995. Review: does measurement of regional cerebral blood flow reflect synaptic activity?: Implications for PET and fMRI. Neuroimage 2:148-156.
32. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. 1995. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52:1048-1060.
33. Lammertsma AA. 2001. PET/SPECT Functional imaging beyond flow. Vision Res 41:1277-1281.
34. Lanius RA, Hopper JW, Menon RS. 2003a. Individual differences in a husband and wife who developed PTSD after a motor vehicle accident: A functional MRI case study. Am J Psychiatry 160: 667-669.
35. Lanius RA, Williamson PC, Bluhm RL, Densmore M, Boksman K, Neufeld RW, Gati JS, Menon RS. 2005. Functional connectivity of dissociative responses in posttraumatic stress disorder: A functional magnetic resonance imaging investigation. Biol Psychiatry 57: 873-884.
36. Lanius RA, Williamson PC, Boksman K, Densmore M, Gupta M, Neufeld RW, Gati JS, Menon RS. 2002. Brain activation during script-driven imagery induced dissociative responses in PTSD: A functional magnetic resonance imaging investigation. Biol Psychiatry 52:305-311.
37. Lanius RA, Williamson PC, Densmore M, Boksman K, Gupta MA, Neufeld RW, Gati JS, Menon RS. 2001. Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation. Am J Psychiatry 158:1920-1922.
38. Lanius RA, Williamson PC, Densmore M, Boksman K, Neufeld RW, Gati JS, Menon RS. 2004. The nature of traumatic memories: A 4-T FMRI functional connectivity analysis. Am J Psychiatry 161: 36-44.
39. Lanius RA, Williamson PC, Hopper J, Densmore M, Boksman K, Gupta MA, Neufeld RW, Gati JS, Menon RS. 2003b. Recall of emotional states in posttraumatic stress disorder: An fMRI investigation. Biol Psychiatry 53:204-210.
40. Liberzon I, Britton JC, Phan KL. 2003. Neural correlates of traumatic recall in posttraumatic stress disorder. Stress 6:151-156.
41. Liberzon I, Taylor SF, Amdur R, Jung TD, Chamberlain KR, Minoshima S, Koeppe RA, Fig LM. 1999. Brain activation in PTSD in response to trauma-related stimuli. Biol Psychiatry 45: 817-826.
42. Liberzon I, Taylor SF, Fig LM, Koeppe RA. 1996. Alteration of corticothalamic perfusion ratios during a PTSD flashback. Depress Anxiety 4:146-150.
43. Lindauer RJ, Booij J, Habraken JB, Uylings HB, Olff M, Carlier IV, den Heeten GJ, van Eck-Smit BL, Gersons BP. 2004. Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder. Biol Psychiatry 56:853-861.
44. Lucey JV, Costa DC, Adshead G, Deahl M, Busatto G, Gacinovic S, Travis M, Pilowsky L, Ell PJ, Marks IM, Kerwin RW. 1997. Brain blood flow in anxiety disorders: OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). Br J Psychiatry 171: 346-350.
45. Mirzaei S, Knoll P, Keck A, Preitler B, Gutierrez E, Umek H, Kohn H, Pecherstorfer M. 2001. Regional cerebral blood flow in patients suffering from post-traumatic stress disorder. Neuropsychobiology 43:260-264.
46. Nakao T, Nakagawa A, Yoshiura T, Nakatani E, Nabeyama M, Yoshizato C, Kudoh A, Tada K, Yoshioka K, Kawamoto M. 2005. A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task. Psychiatry Res 139:101-114.
47. Neylan TC, Schuff N, Lenoci M, Yehuda R, Weiner MW, Marmar CR. 2003. Cortisol levels are positively correlated with hippocampal N-acetylaspartate. Biol Psychiatry 54:1118-1121.
48. Nutt DJ, Malizia AL. 2004. Structural and functional brain changes in posttraumatic stress disorder. J Clin Psychiatry 65(Suppl 1): 11-17.
49. Pagani M, Hogberg G, Salmaso D, Tarnell B, Sanchez-Crespo A, Soares J, Aberg-Wistedt A, Jacobsson H, Hallstrom T, Larsson SA, Sundin O. 2005. Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not posttraumatic stress disorder. Eur Arch Psychiatry Clin Neurosci 255:359-365.
50. Pavic L, Gregurek R, Petrovic R, Petrovic D, Varda R, Vukusic H, Crnkovic-Markovic S. 2003. Alterations in brain activation in posttraumatic stress disorder patients with severe hyperarousal symptoms and impulsive aggressiveness. Eur Arch Psychiatry Clin Neurosci 253:80-83.
51. Pezze MA, Feldon J. 2004. Mesolimbic dopaminergic pathways in fear conditioning. Prog Neurobiol 74:301-320.
52. Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME. 2006. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol Psychiatry 59:424-429.
53. Pissiota A, Frans O, Fernandez M, von Knorring L, Fischer H, Fredrikson M. 2002. Neurofunctjonal correlates of posttraumatic stress disorder: A PET symptom provocation study. Eur Arch Psychiatry Clin Neurosci 252:68-75.
54. Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien W, Epstein J, Yang Y, Gorman J, LeDoux J, Silbersweig D, Stern E. 2005. Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biol Psychiatry 57:464-473.
55. Quirk GJ, Gehlert DR. 2003. Inhibition of the amygdala: key to pathological states? Ann NY Acad Sci 985:263-272.
56. Rauch SL, Shin LM, Segal E, Pitman RK, Carson MA, McMullin K, Whalen PJ, Makris N. 2003. Selectively reduced regional cortical volumes in post-traumatic stress disorder. Neuroreport 14: 913-916.
57. Rauch SL, van der Kolk BA, Fisler RE, Alpert NM, Orr SP, Savage CR, Fischman AJ, Jenike MA, Pitman RK. 1996. A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry 53:380-387.
58. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, Orr SP, Pitman RK. 2000. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biol Psychiatry 47:769-776.
59. Sassi RB, Soares JC. 2003. Brain imaging methods in neuropsychiatry. In: Soares JC, editor. Brain imaging in affective disorders. New York: Marcel Dekker. p 1-17.
60. Schuff N, Neylan TC, Lenoci MA, Du AT, Weiss DS, Marmar CR, Weiner MW. 2001. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry 50:952-959.
61. Scoville WB, Milner B. 2000. Loss of recent memory after bilateral hippocampal lesions** 1957. J Neuropsychiatry Clin Neurosci 12: 103-113.
62. Seedat S, Warwick J, van Heerden B, Hugo C, Zungu-Dirwayi N, Van Kradenburg J, Stein DJ. 2004. Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor. J Affect Disord 80:45-53.
63. Semple WE, Goyer P, McCormick R, Morris E, Compton B, Muswick G, Nelson D, Donovan B, Leisure G, Berridge M, Miraldi F, Schulz SC. 1993. Preliminary report: Brain blood flow using PET in patients with posttraumatic stress disorder and substance-abuse histories. Biol Psychiatry 34:115-118.
64. Semple WE, Goyer PF, McCormick R, Compton-Toth B, Morris E, Donovan B, Muswick G, Nelson D, Garnett ML, Sharkoff J, Leisure G, Miraldi F, Schulz SC. 1996. Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories. Psychiatry Res 67:17-28.
65. Semple WE, Goyer PF, McCormick R, Donovan B, Muzic RF Jr, Rugle L, McCutcheon K, Lewis C, Liebling D, Kowaliw S, Vapenik K, Semple MA, Flener CR, Schulz SC. 2000. Higher brain blood flow at amygdala and lower frontal cortex blood flow in PTSD patients with comorbid cocaine and alcohol abuse compared with normals. Psychiatry 63:65-74.
66. Shaw ME, Strother SC, McFarlane AC, Morris P, Anderson J, Clark CR, Egan GF. 2002. Abnormal functional connectivity in posttraumatic stress disorder. Neuroimage 15:661-674.
67. Shin LM, Kosslyn SM, McNally RJ, Alpert NM, Thompson WL, Rauch SL, Macklin ML, Pitman RK. 1997. Visual imagery and perception in posttraumatic stress disorder. A positron emission tomographic investigation. Arch Gen Psychiatry 54:233-241.
68. Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK. 1999. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. Am J Psychiatry 156:575-584.
69. Shin LM, Orr SP, Carson MA, Rauch SL, Macklin ML, Lasko NB, Peters PM, Metzger LJ, Dougherty DD, Cannistraro PA, Alpert NM, Fischman AJ, Pitman RK. 2004a. Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry 61:168-176.
70. Shin LM, Shin PS, Heckers S, Krangel TS, Macklin ML, Orr SP, Lasko N, Segal E, Makris N, Richert K, Levering J, Schacter DL, Alpert NM, Fischman AJ, Pitman RK, Rauch S. 2004b. Hippocampal function in posttraumatic stress disorder. Hippocampus 14:292-300.
71. Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB, Orr SP, McInerney SC, Rauch SL. 2001. An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biol Psychiatry 50:932-942.
72. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL. 2005. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 62:273-281.
73. Southwick SM, Bremner JD, Rasmusson A, Morgan CA III, Arnsten A, Charney DS. 1999. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry 46:1192-1204.
74. Stain R, Bruijnzeel AW, Wiegant VM. 2000. Long-lasting stress sensitisation. Eur J Pharmacol 405:217-224.
75. van den Heuvel OA, Veltman DJ, Groenewegen HJ, Witter MP, Merkelbach J, Cath DC, van Balkom AJ, van Oppen P, van Dyck R. 2005. Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch Gen Psychiatry 62:922-933.
76. Woodward SH, Kaloupek DCL Streeter CC, Martinez C, Schaer M, Eliez S. 2006. Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry 59:582-587.
77. Yamasue H, Kasai K, Iwanami A, Ohtani T, Yamada H, Abe O, Kuroki N, Fukuda R, Tochigi M, Furukawa S, Sadamatsu M, Sasaki T, Aoki S, Ohtomo K, Asukai N, Kato N. 2003. Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proc Natl Acad Sci USA 100:9039-9043.
78. Yang P, Wu MT, Hsu CC, Ker JH. 2004. Evidence of early neurobiological alternations in adolescents with posttraumatic stress disorder: A functional MRI study. Neurosci Lett 370: 13-18.
79. Zubieta JK, Chinitz JA, Lombardi U, Fig LM, Cameron OG, Liberzon I. 1999. Medial frontal cortex involvement in PTSD symptoms: A SPECTstudy. J Psychiatr Res 33:259-264.