Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials

Molecular Medicine

Volumn 18, Issue 7, 2012, Pages 1045-1055

  Copple, Ian M ^a,c   Mercer, Amy E ^a   Firman, James ^a   Donegan, Gail ^b   Herpers, Bram ^c   Wong, Michael H L ^a   Chadwick, James ^a   Bringela, Andreia D ^d   Cristiano, Maria L S ^d   van de Water, Bob ^c   Ward, Stephen A ^b   O'Neill, Paul M ^a   Kevin Park, B ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF ALGARVE   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIOXOLANE; 1,2,4,5 TETRAOXANE; ANTIMALARIAL AGENT; ARTESUNATE; FBEG 100; HEME; IRON; RKA 182; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; EMBRYOTOXICITY; FEMALE; HUMAN; HUMAN CELL; MALE; NONHUMAN; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CASPASES; CELL DEATH; CELL LINE; EMBRYO, MAMMALIAN; FEMALE; HEME; HUMANS; IRON; MALE; OXIDATIVE STRESS; PLASMODIUM FALCIPARUM; RATS; RATS, SPRAGUE-DAWLEY; SPIRO COMPOUNDS; TERATOGENS; TETRAOXANES; TIME FACTORS;

EID: 84866748241     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2012.00154     Document Type: Article

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