Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 3, 2010, Pages 1042-1046

  Fügi, Matthias A ^a   Wittlin, Sergio ^a   Dong, Yuxiang ^b   Vennerstrom, Jonathan L ^b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2,6,6 TETRAMETHYL 1 PIPERIDINYLOXY; 4 AMINO 2,2,6,6 TETRAMETHYL 1 PIPERIDINYLOXY; 4 CARBOXY 2,2,6,6 TETRAMETHYL 1 PIPERIDINYLOXY; 4 HYDROXY 2,2,6,6 TETRAMETHYL 1 PIPERIDINYLOXY; 4 OXO 2,2,6,6 TETRAMETHYL 1 PIPERIDINYLOXY; ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; ARTEROLANE; CARBAARTEROLANE; CARBON; DEOXYARTEMISININ; DISPIRO[ADAMANTANE 2,3' [1,2,4]TRIOXOLANE 5',4'' CYCLOHEXANEACETIC ACID 2 AMINO 2 METHYLPROPYLAMIDE]; HEME; PEROXIDE; PIPERIDINE DERIVATIVE; PROTOZOAL PROTEIN; RADICAL; UNCLASSIFIED DRUG;

ALKYLATION; ANTIMALARIAL ACTIVITY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG TARGETING; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CYCLIC N-OXIDES; DRUG ANTAGONISM; DRUG RESISTANCE; HETEROCYCLIC COMPOUNDS, 1-RING; INHIBITORY CONCENTRATION 50; LACTONES; PARASITIC SENSITIVITY TESTS; PEROXIDES; PLASMODIUM FALCIPARUM; SPIN LABELS; SPIRO COMPOUNDS;

EID: 77149155618     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01305-09     Document Type: Article

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