Comparative embryotoxicity of different antimalarial peroxides: In vitro study using the rat whole embryo culture model (WEC)

Reproductive Toxicology

Volumn 30, Issue 4, 2010, Pages 583-590

  Longo, Monica ^a   Zanoncelli, Sara ^a   Brughera, Marco ^a   Colombo, Paolo ^a   Wittlin, Sergio ^b   Vennerstrom, Jonathan L ^c   Moehrle, Joerg ^d   Craft, J Carl ^e  

^a Accelera Srl   (Italy)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c NEBRASKA MEDICAL CENTER   (United States)

^d Medicines for Malaria Venture   (Switzerland)

^e MMV   (United States)

Author keywords

Artemisinins; Embryotoxicity; Malaria; Plasmodium falciparum; Primitive red blood cells; Synthetic peroxides; Whole embryo culture

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTEROLENE; CARBA OZ 277; DEOXOARTEMISININ; DISPIRO[ADAMANTANE 2,3' [1,2,4]TRIOXOLANE 5',4'' CYCLOHEXANEACETIC ACID 2 AMINO 2 METHYLPROPYLAMIDE]; OZ 381; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL CELL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; BLOOD VESSEL DIAMETER; BRANCHIAL ARCH; CELL DAMAGE; CELL DEATH; CELL SHAPE; CEPHALOMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROWN RUMP LENGTH; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO GROWTH; EMBRYONIC STRUCTURES; EMBRYOTOXICITY; ERYTHROCYTE; ERYTHROCYTE COUNT; ERYTHROCYTE MEMBRANE; EXPERIMENTAL MODEL; FETUS MEMBRANE; HEAD LENGTH; HEART ARRHYTHMIA; HEART BEAT; HISTOPATHOLOGY; IC 50; MESENCHYME; NEURAL TUBE; NONHUMAN; PERICARDIUM; PLASMODIUM FALCIPARUM; RAT; REDUCED BRANCHIAL ARCH; RETARDED OTIC VESICLE; SHORT CAUDAL EXTREMITY; SITUS INVERSUS; SOMITE; TISSUE INJURY; UNEXPANDED ENCEPHALIC VESSEL; VASCULARIZATION; YOLK SAC; YOLK SAC DIAMETER;

ADAMANTANE; ANIMALS; ANTIMALARIALS; ARTEMISININS; BRANCHIAL REGION; DRUG EVALUATION, PRECLINICAL; EMBRYO CULTURE TECHNIQUES; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ERYTHROCYTES; HETEROCYCLIC COMPOUNDS, 1-RING; INHIBITORY CONCENTRATION 50; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PEROXIDES; PLASMODIUM FALCIPARUM; RATS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TERATOGENS; YOLK SAC;

PLASMODIUM FALCIPARUM; RATTUS;

EID: 78649458344     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.07.011     Document Type: Article

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