Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 10, 2012, Pages 961-968

  Li, Manxiang ^a   Liu, Yuan ^a   Shi, Hongyang ^a   Zhang, Yonghong ^a   Wang, Guizuo ^a   Xu, Jing ^a   Lu, Jiamei ^a   Zhang, Dexin ^a   Xie, Xinming ^a   Han, Dong ^a   Wu, Yuanyuan ^a   Li, Shaojun ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

HO 1; p21WAF1; Proliferation; Pulmonary artery smooth muscle cells; Simvastatin

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; HEME OXYGENASE 1; PROTOPORPHYRIN TIN; SEROTONIN; SIMVASTATIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE SILENCING; NONHUMAN; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER; UPREGULATION;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HEME OXYGENASE-1; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION, PULMONARY; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SEROTONIN; SIMVASTATIN; TRANSFECTION; UP-REGULATION;

EID: 84866733225     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0768-5     Document Type: Article

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