Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension

Hypertension

Volumn 57, Issue 2, 2011, Pages 343-350

  Chen, Ling ^a   Nakano, Kaku ^a   Kimura, Satoshi ^a   Matoba, Tetsuya ^a   Iwata, Eiko ^a   Miyagawa, Miho ^a   Tsujimoto, Hiroyuki ^b   Nagaoka, Kazuhiro ^a   Kishimoto, Junji ^a   Sunagawa, Kenji ^a   Egashira, Kensuke ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b HOSOKAWA MICRON CORPORATION   (Japan)

Author keywords

inflammation; leukocytes; nanotechnology; pitavastatin; pulmonary hypertension

Indexed keywords

ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUINDOSTATIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCROTALINE; PITAVASTATIN; POLYGLACTIN; POLYLACTIC ACID; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG INSTILLATION; DRUG TISSUE LEVEL; HEART HYPERTROPHY; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE PRESSURE; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MALE; MONOCYTE; NONHUMAN; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; SURVIVAL RATE; SYSTOLIC BLOOD PRESSURE;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION, PULMONARY; KAPLAN-MEIER ESTIMATE; LUNG; MALE; MICROSCOPY, FLUORESCENCE; MONOCROTALINE; MYOCYTES, SMOOTH MUSCLE; NANOPARTICLES; NF-KAPPA B; NITRIC OXIDE SYNTHASE; PULMONARY ARTERY; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; REMISSION INDUCTION;

EID: 79551471958     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.157032     Document Type: Article

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