Toward Optimal Operation Conditions of Freeze-Drying Processes via a Multilevel Approach

Drying Technology

Volumn 30, Issue 13, 2012, Pages 1432-1448

  Antelo, Luis T ^a   Passot, Stéphanie ^b   Fonseca, Fernanda ^b   Trelea, Ioan Cristian ^b   Alonso, Antonio A ^a  

^a INSTITUTO DE INVESTIGACIONES MARINAS   (Spain)

^b CEMAGREF   (France)

Author keywords

Control profiles; Dynamic optimization; Freeze drying; Modeling; Real time optimization

Indexed keywords

BIOLOGICAL PROCESSING; BIOLOGICAL PRODUCTS; COMPLEX DYNAMICS; CONTROL PROFILES; CONTROL STRATEGIES; DYNAMIC OPTIMIZATION; FREEZE DRYING; FREEZE-DRYING PROCESS; HIERARCHICAL MULTILEVEL; INTEGRATED APPROACH; LUMPED PARAMETER; MASS AND ENERGY BALANCE; MODEL UNCERTAINTIES; MULTILEVEL APPROACH; NON-LINEARITY; ON-LINE CONTROLS; OPERATIONAL DESIGN; OPTIMAL OPERATION CONDITIONS; OPTIMAL OPERATION POLICY; OPTIMIZATION PROBLEMS; PRODUCT QUALITY; REAL-TIME OPTIMIZATION; SHELF LIFE; STOCHASTIC OPTIMIZATION ALGORITHM;

ALGORITHMS; BIOACTIVITY; DRYING; LOW TEMPERATURE DRYING; MODELS; PLASTIC DEFORMATION; QUALITY CONTROL; UNCERTAINTY ANALYSIS;

OPTIMIZATION;

EID: 84866721627     PISSN: 07373937     EISSN: 15322300     Source Type: Journal    
DOI: 10.1080/07373937.2012.686079     Document Type: Article

References (36)

1. Trelea, I.C.; Passot, S.; Fonseca, F.; Marin, M. An interactive tool for the optimization of freeze-drying cycles based on quality criteria. Drying Technology 2007, 25, 741-751.
2. Pikal, M.J.; Shah, S. The collapse temperature in freeze-drying: Dependence on measurement methodology and rate of water removal from the glassy state. International Journal of Pharmacy 1990, 62, 165-186.
3. Alves, O.; Roos, Y.H. Advances in multi-purpose drying operations with phase and state transitions. Drying Technology 2006, 24, 383-396.
4. Liapis, A.I.; Pikal, M.J.; Bruttini, R. Research and development needs and opportunities in freeze-drying. Drying Technology 1996, 14, 1265-1300.
5. Pisano, R.; Fissore, D.; Velardi, S.A.; Barresi, A.A. In-line optimization and control of an industrial freeze-drying process for pharmaceuticals. Journal of Pharmaceutical Sciences 2011, 99 (10), 4691-4709.
6. Rene, F.; Wolff, E.; Rodolphe, F. Vacuum freeze-drying of a liquid in a vial: Determination of heat and mass-transfer coefficients and optimisation of operating pressure. Chemical Engineering and Processing 1993, 32, 245-251.
7. Boss, E.A.; Filho, R.M.; Vasco de Toledo, E.C. Freeze-drying process: Real time model and optimization. Chemical Engineering and Processing 2004, 43, 1475-1485.
8. Gan, K.H.; Bruttini, R.; Crosser, O.K.; Liapis, A.I. Heating policies during the primary and secondary drying stages of the lyophilization process in vials: Effects of the arrangement of vials in clusters of square and hexagonal arrays on trays. Drying Technology 2004, 22, 1539-1575.
9. Gan, K.H.; Crosser, O.K.; Liapis, A.I.; Bruttini, R. Lyophilization in vials on trays: Effects of tray side on lyophilisation performance. Drying Technology 2005, 23, 341-363.
10. Liapis, A.I.; Bruttini, R. Freeze-drying of pharmaceutical crystalline and amorphous solutes in vials - Dynamic multidimensional models of the primary and secondary drying stages and qualitative features of the moving interface. Drying Technology 1995, 13, 43-72.
11. Sadikoglu, H.; Liapis, A.I. Mathematical modelling of the primary and secondary drying stages of bulk solution freeze-drying in trays: parameter estimation and model discrimination by comparison of theoretical results with experimental data. Drying Technology 1997, 15, 791-810.
12. Sadikoglu, H.; Liapis, A.I.; Crosser, O.K. Optimal control of the primary and secondary drying stages of bulk solution freeze drying in trays. Drying Technology 1998, 16, 399-431.
13. Cheng, J.; Yang, Z.R.; Chen, H.Q. Analytical solutions for the moving interface problem in freeze-drying with or without back heating. Drying Technology 2002, 20, 553-567.
14. Jafar, F.; Farid, M. Analysis of heat and mass transfer in freeze drying. Drying Technology 2003, 21, 249-263.
15. Chouvenc, P.; Vessot, S.; Andrieu, J.; Vacus, P. Optimization of the freeze-drying cycle: a new model for pressure rise analysis. Drying Technology 2004, 22, 1577-1601.
16. Hottot, A.; Peczalski, R.; Vessot, S.; Andrieu, J. Freeze-drying of pharmaceutical proteins in vials: Modeling of freezing and sublimation steps. Drying Technology 2006, 24, 561-570.
17. Sadikoglu, H.; Ozdemir, M.; Seker, M. Optimal control of the primary drying of solutions in vials using variational calculus. Drying Technology 2003, 21, 1307-1331.
18. Sadikoglu, H. Optimal control of the secondary drying stage of solutions in vials using variational calculus. Drying Technology 2005, 23, 33-57.
19. Sadikoglu, H.; Ozemir, M.; Seker, M. Freeze-drying of pharmaceutical products: Research and development needs. Drying Technology 2006, 24, 849-861.
20. Velardi, S.A.; Barresi, A.A. Development of simplified models for the freeze-drying process and investigation of the optimal operating conditions. Chemical Engineering Research and Design 2008, 86, 9-22.
21. Fissore, D.; Velardi, S.A.; Barresi, A.A. In-line control of a freeze-drying process in vials. Drying Technology 2008, 26, 685-694.
22. Millman, M.J.; Liapis, A.I.; Marchello, J.M. An analysis of the lyophilization process using a sorption-sublimation model and various operational policies. AIChE Journal 1985, 31, 1594-1604.
23. Vassiliadis, V.S.; Computational solution of dynamic optimizations problems with general differantial-algebraic constraints. Ph.D. thesis, Imperial College, University of London, 1993.
24. Vassiliadis, V.S.; Pantelides, C.C.; Sargent, R.W.H. Solution of a class of multistage dynamic optimization problems. 1. Problems without path constraints. Industrial and Engineering Chemistry Research 1994, 33 (9), 2111-2122.
25. García, M.S.G.; Balsa-Canto, E.; Alonso, A.A.; Banga, J.R. Computing optimal operating policies for the food industry. Journal of Food Engineering 2006, 74 (1), 13-23.
26. Balsa-Canto, E.; Banga, J.R.; Alonso, A.A.; Vassiliadis, V.B. Dynamic optimization of distributed parameter systems using second-order directional derivatives. Industrial and Engineering Chemistry Research 2004, 43 (21), 6756-6765.
27. Chachuat, B.; Singer, A.B.; Barton, P.I. Global methods for dynamic optimization and mixed-integer dynamic optimization. Industrial and Engineering Chemistry Research 2006, 45 (25), 8373-8392.
28. Storn, R.; Price, K.Differential evolution-A simple and efficient heuristic for global optimization over continuous spaces. Journal of Global Optimization1997, 11, 341-359.
29. Auger, A.; Hansen, N. A restart CMA evolution strategy with increasing population size. In Proceedings of 2005 IEEE Congress on Evolutionary Computation (CEC'2005), Edinburg, UK, September 2-4 2005.
30. Egea, J.A.; Rodríguez-Fernández, M.; Banga, J.R.; Martí, R. Scatter search for chemical and bio-process optimization. Journal of Global Optimization 2007, 37 (3), 481-503.
31. Banga, J.R.; Balsa- Canto, E.; Moles, C.G.; Alonso, A.A. Dynamic optimization of bioprocesses: Efficient and robust numerical strategies. Journal of Biotechnology 2005, 117 (4), 407-419.
32. Egea, J.A.; Balsa-Canto, E.; García, M.S.G.; Banga, J.R. Dynamic optimization of nonlinear processes with an enhanced scatter search method. Industrial and Engineering Chemistry Research 2009, 48 (9), 4388-4401.
33. The Mathworks. Optimization Toolbox 4 User Guide; The Mathworks: Natick, MA. 2008.
34. Jones, D.R. DIRECT global optimization algorithm. In Encyclopedia of Optimization; Floudas, C.A., Pardalos, P.M., Eds.; Kluwer Academic Publishers: Dordrecht, The Netherlands, 2001; 431-440.
35. Exler, O.; Schittkowski, K. A trust region sqp algorithm for mixed-integer nonlinear programming. Optimization Letters 2007, 1, 269-280.
36. Wächter, A.; Biegler, L.T. On the implementation of a primal-dual interior point filter line search algorithm for large-scale nonlinear programming. Mathematical Programming 2006, 106 (1), 25-57.