Freeze drying process: Real time model and optimization

Chemical Engineering and Processing: Process Intensification

Volumn 43, Issue 12, 2004, Pages 1475-1485

  Boss, Edinara Adelaide ^a   Filho, Rubens Maciel ^a   Vasco De Toledo, Eduardo Coselli ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Dynamic process; Freeze drying; Mathematical model; Optimization

Indexed keywords

ENERGY UTILIZATION; MATHEMATICAL MODELS; MOISTURE; NONLINEAR EQUATIONS; POLYNOMIAL APPROXIMATION; QUADRATIC PROGRAMMING; SUBLIMATION;

ENERGY BALANCE; FREEZE DRYING; SUCCESSIVE QUADRATIC PROGRAMMING (SQP);

DRYING;

FREEZE DRYING; OPTIMIZATION; SEPARATION;

EID: 4644249824     PISSN: 02552701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cep.2004.01.005     Document Type: Article

References (7)

1. P.J. Gloor, O.K. Grosser, A.I. Liapis, Dusty-gas parametras of activated carbon desorbent particles, Chem. Eng. Commun. 59 (1987) 95-105.
2. A.I. Liapis, H. Sadikoglu, Mathematical modeling of the primary and secondary drying stages of bulk solution freeze-drying in trays: parameter estimation and model discrimination by comparison of the theoretical results with experimental data. Drying Technol. 15 (3-4) (1997) 791-810.
3. A.I. Liapis, R. Bruttini, M.J. Pikal. Research and development needs and opportunities in freeze drying, Drying Technol. 14 (6) (1996) 1265-1300.
4. R.J. Lichtfield, A.I. Liapis, An absorption-rsublimation model for a freeze dryer, Chem. Eng. Sci. 34 (9) (1979) 1085-1090.
5. M.J. Millman, A.I. Liapis, J.M. Marchello, An analysis of the lyophilization process using a sorption-sublimation model and various operational policies, AIChE J. 31 (10) (1985) 1594-1604.
6. R.L. Plackett, J.P. Burman, The design of optimum multifactorial experiments, Biometrika 33 (1946) 305-325.
7. K. Schittkowski, NLPQL: A FORTRAN-subrontine for solving constrained non-linear programming problems, Ann. Operat. Res. 5 (1985) 485-500.