메뉴 건너뛰기




Volumn 22, Issue 7, 2004, Pages 1577-1601

Optimization of the freeze-drying cycle: A new model for pressure rise analysis

Author keywords

Freeze dryer control; Ice sublimation temperature; MTM model; Pharmaceuticals freeze drying; PRA model

Indexed keywords

FREEZING; MASS TRANSFER; NUMERICAL ANALYSIS; OPTIMIZATION; PRESSURE EFFECTS; SUBLIMATION;

EID: 5444256705     PISSN: 07373937     EISSN: None     Source Type: Journal    
DOI: 10.1081/DRT-200025605     Document Type: Article
Times cited : (88)

References (14)
  • 1
    • 0030846563 scopus 로고    scopus 로고
    • Evaluation of manometric temperature measurement as a method of monitoring product temperature during lyophilization
    • Milton, N.; Pikal, M.J.; Roy, M.L.; Nail, S.L. Evaluation of manometric temperature measurement as a method of monitoring product temperature during lyophilization. PDA Journal of Pharmaceutical Science and Technology 1997, 51 (1), 7-16.
    • (1997) PDA Journal of Pharmaceutical Science and Technology , vol.51 , Issue.1 , pp. 7-16
    • Milton, N.1    Pikal, M.J.2    Roy, M.L.3    Nail, S.L.4
  • 2
    • 0001904754 scopus 로고
    • Freeze-drying of proteins, Part I: Process design
    • Pikal, M.J. Freeze-drying of proteins, part I: process design. Biopharm 1990, 3, 18-27.
    • (1990) Biopharm , vol.3 , pp. 18-27
    • Pikal, M.J.1
  • 4
    • 0032125231 scopus 로고    scopus 로고
    • Dynamic pressure rise in the drying chamber as a remote sensing method for monitoring the temperature of the product during the primary drying stage of freeze-drying
    • Liapis, A.I.; Sadikoglu, H. Dynamic pressure rise in the drying chamber as a remote sensing method for monitoring the temperature of the product during the primary drying stage of freeze-drying. Drying Technology 1998, 16 (6), 1153-1171.
    • (1998) Drying Technology , vol.16 , Issue.6 , pp. 1153-1171
    • Liapis, A.I.1    Sadikoglu, H.2
  • 7
    • 84860239091 scopus 로고    scopus 로고
    • Heat and mass transfer in low pressure gases: Applications to freeze-drying
    • Amidon, G.L., Lee, P.I., Topp, E.M., Eds.; Marcel Dekker: NY
    • Pikal, M.J. Heat and mass transfer in low pressure gases: applications to freeze-drying. In Transport Processes in Pharmaceutical Systems; Amidon, G.L., Lee, P.I., Topp, E.M., Eds.; Marcel Dekker: NY, 2000; 611-686.
    • (2000) Transport Processes in Pharmaceutical Systems , pp. 611-686
    • Pikal, M.J.1
  • 8
    • 0032553851 scopus 로고    scopus 로고
    • Modeling of the primary and secondary drying stages of the freeze-drying of pharmaceutical products in vials: Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies
    • Sheehan, P.; Liapis, A.I. Modeling of the primary and secondary drying stages of the freeze-drying of pharmaceutical products in vials: numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies. Biotechnology and Bioengineering 1998, 60, 712-728.
    • (1998) Biotechnology and Bioengineering , vol.60 , pp. 712-728
    • Sheehan, P.1    Liapis, A.I.2
  • 9
    • 0021836493 scopus 로고
    • Use of laboratory data in freeze-drying process design: Heat and mass transfer coefficients and the computer simulation of freeze-drying
    • May-June
    • Pikal, M.J. Use of laboratory data in freeze-drying process design: heat and mass transfer coefficients and the computer simulation of freeze-drying. Journal of Parenteral Science and Technology. May-June 1985, 39 (3), 115-139.
    • (1985) Journal of Parenteral Science and Technology , vol.39 , Issue.3 , pp. 115-139
    • Pikal, M.J.1
  • 10
    • 0024602083 scopus 로고
    • Process control in freeze-drying: Determination of the end point of sublimation drying by an electronic moisture sensor
    • Mar.-Apr
    • Roy, M.L.; Pikal, M.J. Process control in freeze-drying: determination of the end point of sublimation drying by an electronic moisture sensor. Journal of Parenteral Science and Technology Mar.-Apr. 1989, 43 (2), 60-66.
    • (1989) Journal of Parenteral Science and Technology , vol.43 , Issue.2 , pp. 60-66
    • Roy, M.L.1    Pikal, M.J.2
  • 12
    • 0026486105 scopus 로고
    • Methodology for in process determination of residual water in freeze-drying products
    • Bethesda, USA, 1990; Dev. Biol. Stand: Karger, Basel, 137-151
    • Nail, S.L. Methodology for in process determination of residual water in freeze-drying products. International Symposium on Biological Product Freeze-Drying and Formulation, Bethesda, USA, 1990; Dev. Biol. Stand: Karger, Basel, 1991; 74, 137-151.
    • (1991) International Symposium on Biological Product Freeze-Drying and Formulation , pp. 74
    • Nail, S.L.1
  • 13
    • 0030190595 scopus 로고    scopus 로고
    • Research and development needs and opportunities in freeze drying
    • Liapis, A.I.; Pikal, M.J.; Bruttini, R. Research and development needs and opportunities in freeze drying. Drying Technology 1996, 14 (6), 1265-1300.
    • (1996) Drying Technology , vol.14 , Issue.6 , pp. 1265-1300
    • Liapis, A.I.1    Pikal, M.J.2    Bruttini, R.3
  • 14
    • 0031102433 scopus 로고    scopus 로고
    • Mathematical modeling of primary and secondary drying stages of bulk solution freeze-drying in trays: Parameter estimation and model discrimination by comparison of theoretical results with experimental data
    • Sadikoglu, H.; Liapis, A.I. Mathematical modeling of primary and secondary drying stages of bulk solution freeze-drying in trays: parameter estimation and model discrimination by comparison of theoretical results with experimental data. Drying Technology 1997, 15, 791-810.
    • (1997) Drying Technology , vol.15 , pp. 791-810
    • Sadikoglu, H.1    Liapis, A.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.