Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity

Stem Cells

Volumn 30, Issue 10, 2012, Pages 2088-2099

  Voon, Dominic Chih Cheng ^a   Wang, Huajing ^a   Koo, Jason Kin Wai ^a   Nguyen, Tu Anh Pham ^b   Hor, Yit Teng ^a   Chu, Yeh Shiu ^b   Ito, Kosei ^c   Fukamachi, Hiroshi ^d   Chan, Shing Leng ^a   Thiery, Jean Paul ^b   Ito, Yoshiaki ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c NAGASAKI UNIVERSITY   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Epithelial mesenchymal transition; Gastric cancer stem cell; Lgr5; RUNX3; TGF ; Wnt

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR RUNX3; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CARCINOGENICITY; CELL POPULATION; CELL PROTECTION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; STOMACH MUCOSA CELL;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CORE BINDING FACTOR ALPHA 3 SUBUNIT; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GASTROINTESTINAL NEOPLASMS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; RECEPTORS, G-PROTEIN-COUPLED; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84866659449     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1183     Document Type: Article

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