Runx1/AML-1 ranks as a master regulator of adult hematopoiesis

Cell Cycle

Volumn 3, Issue 6, 2004, Pages 720-722

  Ichikawa, Motoshi ^a   Asai, Takashi ^a   Chiba, Shigeru ^a   Kurokawa, Mineo ^a   Ogawa, Seishi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hematopoietic stem cells; Leukemogenesis; Platelets; Runx1; Transcription factors

Indexed keywords

DROSOPHILA PROTEIN; TRANSCRIPTION FACTOR RUNX1;

ACUTE GRANULOCYTIC LEUKEMIA; B LYMPHOCYTE; BONE MARROW CELL; CANCER SUSCEPTIBILITY; CELL MATURATION; CHROMOSOME 8; CHROMOSOME TRANSLOCATION; GENE CONTROL; GENE DISRUPTION; GENE FUNCTION; HEMATOPOIESIS; IN VITRO STUDY; KNOCKOUT MOUSE; LEUKEMIA; LEUKEMOGENESIS; MEGAKARYOCYTE; NONHUMAN; REVIEW; SEQUENCE HOMOLOGY; T LYMPHOCYTE; THROMBOCYTE ANOMALY;

DROSOPHILA;

EID: 13244277465     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.6.951     Document Type: Review

References (21)

1. Dzierzak E, Medvinsky A, Mouse embryonic hematopoiesis. Trend Genet 1995; 11:359-66.
2. Medvinsky A, Dzierzak E. Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 1990; 86:897-906.
3. Lutterbach B, Hiebert SW. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 2000; 245:223-35.
4. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 1996; 84:321-30.
5. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 1996; 93:3444-9.
6. North TE, de Bruijn MF, Stacy T, Talebian L, Lind E, Robin C, et al. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity 2002; 16:661-72.
7. Rhoades KL, Hetherington CJ, Harakawa N, Yergeau DA, Zhou L, Liu LQ, et al. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood 2000; 96:2108-15.
8. de Guzman CG, Warren AJ, Zhang Z, Gartland L, Erickson P, Drabkin H, et al. Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol Cell Biol 2002; 22:5506-17.
9. Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 2002; 1:63-74.
10. Ichikawa M, Asai T, Saito T, Yamamoto G, Seo S, Yamazaki I, et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med 2004; 10:299-304.
11. Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 2003; 421:547-51.
12. Kunisato A, Chiba S, Saito T, Kumano K, Nakagami-Yamaguchi E, Yamaguchi T, et al. Stem cell leukemia (SCL) directs hematopoietic stem cell fate. Blood 2004; 103:3336-41.
13. Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 1999; 23:166-75.
14. Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood 1999; 93:1817-24.
15. Imai Y, Kurokawa M, Izutsu K, Hangaishi A, Takeuchi K, Maki K, et al. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis. Blood 2000; 96:3154-60.
16. Preudhomme C, Warot-Loze D, Roumier C, Grardel-Duflos N, Garand R, Lai JL, et al. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 2000; 96:2862-9.
17. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 1997; 16:3965-73.
18. Takahashi S, Komeno T, Suwabe N, Yoh K, Nakajima O, Nishimura S, et al. Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo. Blood 1998; 92:434-42.
19. Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, et al. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity 2000; 13:167-77.
20. Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN. RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood 2003; 101:4333-41.
21. Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 2002; 111:621-33.