Antidiabetic Potentials of a Novel Polyherbal Preparation Formulated According to Principles of Siddha System of Medicine

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 17, Issue 3, 2012, Pages 180-190

  Balaji, Venkataraman ^a   Williams, Augustine Anne ^a   Sathish, Sampath ^a   Mayilvanan, Chinnaiyan ^a   Narasimhan, Akilavalli ^a   Balasubramanian, Karundevi ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

antioxidants; polyherbal preparation; Siddha; type 2 diabetes

Indexed keywords

EID: 84866654182     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: 10.1177/2156587212451027     Document Type: Article

References (82)

1. Thas JJ.Siddha medicine-background and principles and the application for skin diseases.Clin Dermatol. 2008;26:62-78.
2. Ji HF,Li XJ,Zhang HY.Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?.EMBO Rep. 2009;10:194-200.
3. Niwano Y,Saito K,Yoshizaki F,Kohno M,Ozawa T.Extensive screening for herbal extracts with potent antioxidant properties.J Clin Biochem Nutr. 2011;48:78-84.
4. Wiboonpun N,Phuwapraisirisan P,Tip-pyang S.Identification of antioxidant compound from Asparagus racemosus.Phytother Res. 2004;18:771-773.
5. Jihong Y,Shaozhong L,Jingfeng S, et al.Effects of Salacia chinensis extract on reproductive outcome in rats.Food Chemical Toxicol. 2011;49:57-60.
6. Scartezzini P,Speroni E.Review on some plants of Indian traditional medicine with antioxidant activity.J Ethnopharmacol. 2000;71:23-43.
7. Sharma P,Chauhan PS,Dutt P, et al.A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus.Steroids. 2011;76:358-364.
8. Parihar MS,Hemnani T.Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus.J Neural Transm. 2004;111:1-12.
9. Bhattacharya SK,Bhattacharya A,Chakrabarti A.Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas.Indian J Exp Biol. 2000;38:119-128.
10. Diwanay S,Chitre D,Patwardhan B.Immunoprotection by botanical drugs in cancer chemotherapy.J Ethnopharmacol. 2004;90:49-55.
11. Dhuley JN.Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice.J Ethnopharmacol. 1997;58:15-20.
12. Antarkar DS,Vaidya AB,Doshi JC, et al.A double-blind clinical trial of Arogya-wardhani-an ayurvedic drug-in acute viral hepatitis.Indian J Med Res. 1980;72:588-593.
13. Sabu MC,Kuttan R.Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property.J Ethnopharmacol. 2002;81:155-160.
14. Zhang YJ,Abe T,Tanaka T,Yang CR,Kouno I.Phyllanemblinins A-F, new ellagitannins from Phyllanthus emblica.J Nat Prod. 2001;64:1527-1532.
15. Wolf BW,Weisbrode SE.Safety evaluation of an extract from Salacia oblonga.Food Chem Toxicol. 2003;41:867-874.
16. Ghavami A,Johnston BD,Pinto BM.A new class of glycosidase inhibitor: synthesis of salacinol and its stereoisomers.J Org Chem. 2001;66:2312-2317.
17. Yoshikawa M,Morikawa T,Matsuda H,Tanabe G,Muraoka O.Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata.Bioorg Med Chem. 2002;10:1547-1554.
18. Yoshikawa M,Murakami T,Yashiro K,Matsuda H.Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata.Chem Pharm Bull (Tokyo). 1998;46:1339-1340.
19. Miyazawa M,Hisama M.Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum).J Agric Food Chem. 2003;51:6413-6422.
20. Ghelardini C,Galeotti N,Di Cesare Mannelli L,Mazzanti G,Bartolini A.Local anaesthetic activity of beta-caryophyllene.Farmaco. 2001;56:387-389.
21. Nangle MR,Gibson TM,Cotter MA,Cameron NE.Effects of eugenol on nerve and vascular dysfunction in streptozotocin-diabetic rats.Planta Med. 2006;72:494-500.
22. Rajamani S,Suganthi R,Ravichandran MK,Anuradha CV.Food seasoning spices mixture improves glucose metabolism and lipid profile in fructose-fed hyperinsulinemic rats.J Med Food. 2005;8:502-507.
23. Bhatt AD,Bhatt NS.Indigenous drugs and liver disease.Indian J Gastroenterol. 1996;15:63-67.
24. Mathew S,Kuttan G.Antioxidant activity of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity.J Exp Clin Cancer Res. 1997;16:407-411.
25. Stanely P,Prince M,Menon VP.Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats.J Ethnopharmacol. 2000;70:9-15.
26. Saad F.The role of testosterone in type 2 diabetes and metabolic syndrome in men.Arq Bras Endocrinol Metabol. 2009;53:901-907.
27. Nampurath GK,Mathew SP,Khanna V,Zachariah RT,Kanji S,Chamallamudi MR.Assessment of hypolipidaemic activity of three thiazolidin-4-ones in mice given high-fat diet and fructose.Chem Biol Interact. 2008;171:363-368.
28. Devasagayam TP,Tarachand U.Decreased lipid peroxidation in the rat kidney during gestation.Biochem Biophys Res Commun. 1987;145:134-138.
29. Pick E,Keisari Y.Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages-induction by multiple nonphagocytic stimuli.Cell Immunol. 1981;59:301-318.
30. Puntarulo S,Cederbaum AI.Comparison of the ability of ferric complexes to catalyze microsomal chemiluminescence, lipid peroxidation, and hydroxyl radical generation.Arch Biochem Biophys. 1988;264:482-491.
31. Misra HP,Fridovich I.The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.J Biol Chem. 1972;247:3170-3175.
32. Takahara S,Hamilton HB,Neel JV,Kobara TY,Ogura Y,Nishimura ET.Hypocatalasemia: a new genetic carrier state.J Clin Invest. 1960;39:610-619.
33. Rotruck JT,Pope AL,Ganther HE,Swanson AB,Hafeman DG,Hoekstra WG.Selenium: biochemical role as a component of glutathione peroxidase.Science. 1973;179:588-590.
34. Habig WH,Pabst MJ,Jakoby WB.Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.J Biol Chem. 1974;249:7130-7139.
35. Blakytny R,Harding JJ.Glycation (non-enzymic glycosylation) inactivates glutathione reductase.Biochem J. 1992;288 (pt 1): 303-307.
36. Sedlak J,Lindsay RH.Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.Anal Biochem. 1968;25:192-205.
37. Lowry OH,Rosebrough NJ,Farr AL,Randall RJ.Protein measurement with the Folin phenol reagent.J Biol Chem. 1951;193:265-275.
38. MacKenzie NM,Keeler KD.A flow microfluorimetric analysis of the binding of immunoglobulins to Fc gamma receptors on brush borders of the neonatal mouse jejunal epithelium.Immunology. 1984;51:529-533.
39. Thomas DB,Keeler KD.Flip-flop in the Lyt 2 phenotype of T cells from radiation chimaeras between Thy 1 congenic donor and recipient mice.Immunology. 1984;51:563-570.
40. Wing AM,Keele S,Margolin DI.Motor disorder and the timing of repetitive movements.Ann N Y Acad Sci. 1984;423:183-192.
41. Beutler E,Morrison M.Localization and characteristics of hexose 6-phosphate dehydrogenase (glucose dehydrogenase).J Biol Chem. 1967;242:5289-5293.
42. Hassid W,Abraham SMethods in Enzymology. Colowick SKaplan N, ed. New York, NY: Academic Press; 1957:34-36.
43. Kong DX,Li XJ,Zhang HY.Where is the hope for drug discovery? Let history tell the future.Drug Discov Today. 2009;14:115-119.
44. Oakes ND,Cooney GJ,Camilleri S,Chisholm DJ,Kraegen EW.Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.Diabetes. 1997;46:1768-1774.
45. Grossmann M,Thomas MC,Panagiotopoulos S, et al.Low testosterone levels are common and associated with insulin resistance in men with diabetes.J Clin Endocrinol Metab. 2008;93:1834-1840.
46. Manzano S,Williamson G.Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells.Mol Nutr Food Res. 2010;54:1773-1780.
47. Kobayashi Y,Suzuki M,Satsu H, et al.Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism.J Agric Food Chem. 2000;48:5618-5623.
48. Kapoor D,Aldred H,Clark S,Channer KS,Jones TH.Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity.Diabetes Care. 2007;30:911-917.
49. Thakur M,Chauhan NS,Bhargava S,Dixit VK.A comparative study on aphrodisiac activity of some ayurvedic herbs in male albino rats.Arch Sex Behav. 2009;38:1009-1015.
50. Kapur P,Pereira BM,Wuttke W,Jarry H.Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP.Phytomedicine. 2009;16:679-682.
51. Mishra RK,Singh SK.Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice.Food Chem Toxicol. 2008;46:3333-3338.
52. Goldberg DM,Watts C.Serum enzyme changes as evidence of liver reaction to oral alcohol.Gastroenterology. 1965;49:256-261.
53. Bhattacharya A,Kumar M,Ghosal S,Bhattacharya SK.Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats.Phytomedicine. 2000;7:173-175.
54. Reddy JK,Hashimoto T.Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system.Annu Rev Nutr. 2001;21:193-230.
55. Fischer M,You M,Matsumoto M,Crabb DW.Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.J Biol Chem. 2003;278:27997-28004.
56. Ye JM,Iglesias MA,Watson DG, et al.PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.Am J Physiol Endocrinol Metab. 2003;284:E531-E540.
57. Kim HY,Okubo T,Juneja LR,Yokozawa T.The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model.Br J Nutr. 2010;103:502-512.
58. Zavaroni I,Chen YD,Reaven GM.Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat.Metabolism. 1982;31:1077-1083.
59. de Melo CL,Queiroz MG,Fonseca SG, et al.Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet.Chem Biol Interact. 2010;185:59-65.
60. Lee KG,Shibamoto T.Inhibition of malonaldehyde formation from blood plasma oxidation by aroma extracts and aroma components isolated from clove and eucalyptus.Food Chem Toxicol. 2001;39:1199-1204.
61. Bhatia IS,Bajaj KL.Chemical constituents of the seeds and bark of Syzygium cumini.Planta Med. 1975;28:346-352.
62. Wohaieb SA,Godin DV.Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment.Diabetes. 1987;36:1014-1018.
63. Nicotera P,Orrenius S.Role of thiols in protection against biological reactive intermediates.Adv Exp Med Biol. 1986;197:41-51.
64. Gregus Z,Fekete T,Halászi E,Klaassen CD.Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine.Drug Metab Dispos. 1996;24:682-688.
65. Sies H.Damage to plasmid DNA by singlet oxygen and its protection.Mutat Res. 1993;299:183-191.
66. Monagas M,Hernández-Ledesma B,Gómez-Cordovés C,Bartolomé B.Commercial dietary ingredients from Vitis vinifera L. leaves and grape skins: antioxidant and chemical characterization.J Agric Food Chem. 2006;54:319-327.
67. Liu X,Zhao M,Luo W,Yang B,Jiang Y.Identification of volatile components in Phyllanthus emblica L. and their antimicrobial activity.J Med Food. 2009;12:423-428.
68. Meister A.Glutathione-ascorbic acid antioxidant system in animals.J Biol Chem. 1994;269:9397-9400.
69. Singh RP,Banerjee S,Kumar PV,Raveesha KA,Rao AR.Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice.Phytomedicine. 2006;13:74-84.
70. Goyal RK,Singh J,Lal H.Asparagus racemosus-an update.Indian J Med Sci. 2003;57:408-414.
71. Shimizu T,Parker JC,Najafi H,Matschinsky FM.Control of glucose metabolism in pancreatic beta-cells by glucokinase, hexokinase, and phosphofructokinase. Model study with cell lines derived from beta-cells.Diabetes. 1988;37:1524-1530.
72. Weber G,Convery HJ.Insulin: inducer of glucose 6-phosphate dehydrogenase.Life Sci. 1966;5:1139-1146.
73. Yoon JC,Puigserver P,Chen G, et al.Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.Nature. 2001;413:131-138.
74. Boustead JN,Stadelmaier BT,Eeds AM, et al.Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells.Biochem J. 2003;369 (pt 1): 17-22.
75. Sultana S,Ahmed S,Jahangir T.Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats.J Ethnopharmacol. 2008;118:1-6.
76. Levy J,Stern Z,Gutman A,Naparstek Y,Gavin JR,Avioli LV.Plasma calcium and phosphate levels in an adult noninsulin-dependent diabetic population.Calcif Tissue Int. 1986;39:316-318.
77. Kesteloot H,Geboers J.Calcium and blood pressure.Lancet. 1982;1:813-815.
78. Lind L,Jakobsson S,Lithell H,Wengle B,Ljunghall S.Relation of serum calcium concentration to metabolic risk factors for cardiovascular disease.BMJ. 1988;297:960-963.
79. Jorde R,Sundsfjord J,Fitzgerald P,Bønaa KH.Serum calcium and cardiovascular risk factors and diseases: the Tromsø study.Hypertension. 1999;34:484-490.
80. Sun G,Vasdev S,Martin GR,Gadag V,Zhang H.Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland population.Diabetes. 2005;54:3336-3339.
81. Yadav UC,Moorthy K,Baquer NZ.Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats.Mol Cell Biochem. 2005;268:111-120.
82. Vats V,Yadav SP,Grover JK.Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats.J Ethnopharmacol. 2004;90:155-160.