Effects of endothelial cells on human mesenchymal stem cell activity in a three-dimensional in vitro model

European Cells and Materials

Volumn 22, Issue , 2011, Pages 242-257

  Saleh, F A ^a   Whyte, M ^b   Genever, P G ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b Smith and Nephew Research Centre   (United Kingdom)

Author keywords

3D models; Endothelial cells; Mesenchymal stem cells; Osteogenesis; Perivascular niche

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; WNT PROTEIN; CTNNB1 PROTEIN, HUMAN;

ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL CULTURE; CELL DIFFERENTIATION; CELL FATE; CELL INTERACTION; CELL LABELING; CELL POPULATION; CELL PROLIFERATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MESENCHYMAL STEM CELL; OSTEOBLAST; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; BIOLOGICAL MODEL; BIOSYNTHESIS; BONE DEVELOPMENT; CELL COMMUNICATION; CELL MOTION; COCULTURE; METABOLISM; PHYSIOLOGY; STEM CELL NICHE; WNT SIGNALING PATHWAY;

BETA CATENIN; BONE MORPHOGENETIC PROTEINS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MESENCHYMAL STEM CELLS; MODELS, BIOLOGICAL; OSTEOGENESIS; SMAD PROTEINS; STEM CELL NICHE; WNT SIGNALING PATHWAY;

EID: 84857132365     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v022a19     Document Type: Article

References (52)

1. Arufe MC, De la FA, Fuentes-Boquete I, de Toro FJ, Blanco FJ (2009) Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation. J Cell Biochem 108: 145-155.
2. Bartosh TJ, Ylostalo JH, Mohammadipoor A, Bazhanov N, Coble K, Claypool K, Lee RH, Choi H, Prockop DJ (2010) Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci USA 107: 13724-13729.
3. Blasi A, Martino C, Balducci L, Saldarelli M, Soleti A, Navone SE, Canzi L, Cristini S, Invernici G, Parati EA, Alessandri G (2011) Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential. Vasc Cell 3: 5.
4. Carrion B, Huang CP, Ghajar CM, Kachgal S, Kniazeva E, Jeon NL, Putnam AJ (2010) Recreating the perivascular niche ex vivo using a microfluidic approach. Biotechnol Bioeng 107: 1024-1032.
5. Castrechini NM, Murthi P, Gude NM, Erwich JJHM, Gronthos S, Zannettino A, Brennecke SP, Kalionis B (2010) Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche. Placenta 31: 203-212.
6. Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Peault B (2008a) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3: 301-313.
7. Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Peault B (2008b) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3: 301-313.
8. Cukierman E, Pankov R, Stevens DR, Yamada KM (2001) Taking cell-matrix adhesions to the third dimension. Science 294: 1708-1712.
9. Cukierman E, Pankov R, Yamada KM (2002) Cell interactions with three-dimensional matrices. Curr Opin Cell Biol 14: 633-639.
10. da Silva ML, Caplan AI, Nardi NB (2008) In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26: 2287-2299.
11. da Silva ML, Chagastelles PC, Nardi NB (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119: 2204-2213.
12. Dean DM, Napolitano AP, Youssef J, Morgan JR (2007) Rods, tori, and honeycombs: the directed self-assembly of microtissues with prescribed microscale geometries. FASEB J 21: 4005-4012.
13. Dittmer A, Hohlfeld K, Lützkendorf J, Müller L, Dittmer J (2009) Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10. Cell Mol Life Sci 66: 3053-3065.
14. Etheridge SL, Spencer GJ, Heath DJ, Genever PG (2004) Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 22: 849-860.
15. Foty RA, Steinberg MS (2005) The differential adhesion hypothesis: a direct evaluation. Dev Biol 278: 255-263.
16. Frith JE, Thomson B, Genever PG (2010) Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods 16: 735-749.
17. Fuchs S, Hofmann A, Kirkpatrick CJ (2007) Microvessel-like structures from outgrowth endothelial cells from human peripheral blood in 2-dimensional and 3-dimensional co-cultures with osteoblastic lineage cells. Tissue Eng 13: 2577-2588.
18. Goldbrunner RH, Wagner S, Roosen K, Tonn JC (2000) Models for assessment of angiogenesis in gliomas. J Neurooncol 50: 53-62.
19. Grayson WL, Zhao F, Izadpanah R, Bunnell B, Ma T (2006) Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J Cell Physiol 207: 331-339.
20. Green JA, Yamada KM (2007) Three-dimensional microenvironments modulate fibroblast signaling responses. Adv Drug Deliv Rev 59: 1293-1298.
21. Grellier M, Bordenave L, Amedee J (2009a) Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering. Trends Biotechnol 27: 562-571.
22. Grellier M, Granja PL, Fricain JC, Bidarra SJ, Renard M, Bareille R, Bourget C, Amedee J, Barbosa MA (2009b) The effect of the co-immobilization of human osteoprogenitors and endothelial cells within alginate microspheres on mineralization in a bone defect. Biomaterials 30: 3271-3278.
23. Griffith LG, Swartz MA (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7: 211-224.
24. Guillotin B, Bareille R, Bourget C, Bordenave L, Amedee J (2008) Interaction between human umbilical vein endothelial cells and human osteoprogenitors triggers pleiotropic effect that may support osteoblastic function. Bone 42: 1080-1091.
25. Hager S, Lampert FM, Orimo H, Stark GB, Finkenzeller G (2009) Up-regulation of alkaline phosphatase expression in human primary osteoblasts by cocultivation with primary endothelial cells is mediated by p38 mitogen-activated protein kinase-dependent mRNA stabilization. Tissue Eng Part A 15: 3437-3447.
26. Hofmann A, Ritz U, Verrier S, Eglin D, Alini M, Fuchs S, Kirkpatrick CJ, Rommens PM (2008) The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds. Biomaterials 29: 4217-4226.
27. Hutmacher DW (2010) Biomaterials offer cancer research the third dimension. Nat Mater 9: 90-93.
28. Kaigler D, Krebsbach PH, West ER, Horger K, Huang YC, Mooney DJ (2005) Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB J 19: 665-667.
29. Kyriakidou K, Lucarini G, Zizzi A, Salvolini E, Mattioli Belmonte M, Mollica F, Gloria A, Ambrosio L (2008) Dynamic co-seeding of osteoblast and endothelial cells on 3D polycaprolactone scaffolds for enhanced bone tissue engineering. J Bioact Compat Polymers 23: 227-243.
30. Li H, Daculsi R, Grellier M, Bareille R, Bourget C, Amedee J (2010) Role of neural-cadherin in early osteoblastic differentiation of human bone marrow stromal cells cocultured with human umbilical vein endothelial cells. Am J Physiol Cell Physiol 299: C422-C430.
31. Lorenz K, Sicker M, Schmelzer E, Rupf T, Salvetter J, Schulz-Siegmund M, Bader A (2008) Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol 17: 925-932.
32. Lozito TP, Kuo CK, Taboas JM, Tuan RS (2009) Human mesenchymal stem cells express vascular cell phenotypes upon interaction with endothelial cell matrix. J Cell Biochem 107: 714-722.
33. Lutolf MP, Gilbert PM, Blau HM (2009) Designing materials to direct stem-cell fate. Nature 462: 433-441.
34. Napolitano AP, Chai P, Dean DM, Morgan JR (2007) Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels. Tissue Eng 13: 2087-2094.
35. Pampaloni F, Reynaud EG, Stelzer EH (2007) The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8: 839-845.
36. Rajashekhar G, Traktuev DO, Roell WC, Johnstone BH, Merfeld-Clauss S, Van Natta B, Rosen ED, March KL, Clauss M (2008) IFATS collection: Adipose stromal cell differentiation is reduced by endothelial cell contact and paracrine communication: role of canonical Wnt signaling. Stem Cells 26: 2674-2681.
37. Rangarajan A, Hong SJ, Gifford A, Weinberg RA (2004) Species-and cell type-specific requirements for cellular transformation. Cancer Cell 6: 171-183.
38. Ruiz SA, Chen CS (2008) Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells 26: 2921-2927.
39. Saleh FA, Genever PG (2011) Turning round: multipotent stromal cells, a three-dimensional revolution? Cytotherapy 13: 903-912.
40. Saleh FA, Whyte M, Ashton P, Genever PG (2011) Regulation of mesenchymal stem cell activity by endothelial cells. Stem Cells Dev 20: 391-403.
41. Shi S, Gronthos S (2003) Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 18: 696-704.
42. Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G (2004) Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model. Biochem Biophys Res Commun 322: 684-692.
43. Steinberg MS (1962) On the mechanism of tissue reconstruction by dissociated cells. III. Free energy relations and the reorganization of fused, heteronomic tissue fragments. Proc Natl Acad Sci USA 48: 1769-1776.
44. Sun H, Qu Z, Guo Y, Zang G, Yang B (2007) In vitro and in vivo effects of rat kidney vascular endothelial cells on osteogenesis of rat bone marrow mesenchymal stem cells growing on polylactide-glycoli acid (PLGA) scaffolds. Biomed Eng Online 6: 41.
45. Tapp H, Deepe R, Ingram J, Kuremsky M, Hanley E, Gruber H (2008) Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix. Arthritis Res Ther 10: R89.
46. Unger RE, Sartoris A, Peters K, Motta A, Migliaresi C, Kunkel M, Bulnheim U, Rychly J, Kirkpatrick CJ (2007) Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials. Biomaterials 28: 3965-3976.
47. Villars F, Bordenave L, Bareille R, Amedee J (2000) Effect of human endothelial cells on human bone marrow stromal cell phenotype: role of VEGF? J Cell Biochem 79: 672-685.
48. Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, Blake J, Schwager C, Eckstein V, Ansorge W, Ho AD (2005) Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 33: 1402-1416.
49. Wang CC, Chen CH, Hwang SM, Lin WW, Huang CH, Lee WY, Chang Y, Sung HW (2009a) Spherically symmetric mesenchymal stromal cell bodies inherent with endogenous extracellular matrices for cellular cardiomyoplasty. Stem Cells 27: 724-732.
50. Wang W, Itaka K, Ohba S, Nishiyama N, Chung UI, Yamasaki Y, Kataoka K (2009b) 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30: 2705-2715.
51. Xu Y, Swerlick RA, Sepp N, Bosse D, Ades EW, Lawley TJ (1994) Characterization of expression and modulation of cell adhesion molecules on an immortalized human dermal microvascular endothelial cell line (HMEC-1). J Invest Dermatol 102: 833-837.
52. Yamada KM, Cukierman E (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130: 601-610.