Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 6, 2008, Pages

  Potapova, Irina A ^a   Doronin, Sergey V ^a   Kelly, Damon J ^a,b   Rosen, Amy B ^b,c   Schuldt, Adam J T ^b,c   Lu, Zhongju ^a,b   Kochupura, Paul V ^b   Robinson, Richard B ^d   Rosen, Michael R ^d   Brink, Peter R ^a,b   Gaudette, Glenn R ^e   Cohen, Ira S ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c St Francis Hospital The Heart Center   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e Worcester Polytechnic Institute   (United States)

Author keywords

Cardiac contractile function; Cardiac regeneration; Heart failure; Human mesenchymal stem cells; Myocardium; Myocyte structure; Myogenesis

Indexed keywords

ALPHA ACTININ; ATRIAL NATRIURETIC FACTOR; CALCIUM CHANNEL L TYPE; CELL NUCLEUS ANTIGEN; CYCLIN D1; TISSUE SCAFFOLD;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; DOG; EXTRACELLULAR MATRIX; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE DEFECT; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPHEROID CELL; TISSUE REGENERATION;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CELL DIFFERENTIATION; CELL LINEAGE; DISEASE MODELS, ANIMAL; DOGS; EXTRACELLULAR MATRIX; HEART DISEASES; HEART VENTRICLES; HUMANS; MEMBRANE POTENTIALS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; REGENERATION; SARCOMERES; SPHEROIDS, CELLULAR; SWINE; TISSUE SCAFFOLDS; URINARY BLADDER; VENTRICULAR FUNCTION, RIGHT;

EID: 57349197114     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00219.2008     Document Type: Article

References (19)

1. Azeloglu EU, Kochupura PV, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR. Acellularized urinary bladder matrix: a functional myocardial patch. Proc Biomed Eng Soc Ann Fall Meet, 2004.
2. Azeloglu EU, Yun YH, Saltman AE, Krukenkamp IB, Chiang FP, Chen W, Gaudette GR. High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location. J Biomech 39: 717-725, 2006.
3. Badylak SF, Kochupura PV, Cohen IS, Doronin SV, Saltman AE, Gilbert TW, Kelly DJ, Ignotz RA, Gaudette GR. The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium. Cell Transplant 15, Suppl 1: S29-S40, 2006.
4. Gaudette GR, Todaro J, Krukenkamp IB, Chiang FP. Computer aided speckle interferometry: a technique for measuring deformation of the surface of the heart. Ann Biomed Eng 29: 775-780, 2001.
5. Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 20: 661-669, 2006.
6. Heubach JF, Graf EM, Leutheuser J, Bock M, Balana B, Zahanich I, Christ T, Boxberger S, Wettwer E, Ravens U. Electrophysiological properties of human mesenchymal stem cells. J Physiol 554: 659-672, 2004.
7. Keller GM. In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 7: 862-869, 1995.
8. Kelly DJ, Azeloglu EU, Kochupura PV, Sharma GS, Gaudette GR. Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacements in the heart. Med Eng Phys 29: 154-162, 2007.
9. Kelm JM, Timmins NE, Brown CJ, Fussenegger M, Nielsen LK. Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng 83: 173-180, 2003.
10. Kochupura PV, Azeloglu EU, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR. Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function. Circulation 112: I144-I149, 2005.
11. Li F, Li W, Johnson S, Ingram D, Yoder M, Badylak S. Low-molecular-weight peptides derived from extracellular matrix as chemoattractants for primary endothelial cells. Endothelium 11: 199-206, 2004.
12. Li GR, Lau CP, Leung TK, Nattel S. Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 1: 460-468, 2004.
13. Li GR, Sun H, Deng X, Lau CP. Characterization of ionic currents in human mesenchymal stem cells from bone marrow. Stem Cells 23: 371-382, 2005.
14. Murry CE, Reinecke H, Pabon LM. Regeneration gaps: observations on stem cells and cardiac repair. J Am Coll Cardiol 47: 1777-1785, 2006.
15. Noiseux N, Gnecchi M, Lopez-Ilasaca M, Zhang L, Solomon SD, Deb A, Dzau VJ, Pratt RE. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther 14: 840-850, 2006.
16. Pelzmann B, Schaffer P, Bernhart E, Lang P, Machler H, Rigler B, Koidl B. L-type calcium current in human ventricular myocytes at a physiological temperature from children with tetralogy of Fallot. Cardiovasc Res 38: 424-432, 1998.
17. Rosen AB, Kelly DJ, Schuldt AJ, Lu J, Potapova IA, Doronin SV, Robichaud KJ, Robinson RB, Rosen MR, Brink PR, Gaudette GR, Cohen IS. Finding fluorescent needles in the cardiac haystack: tracking human mesenchymal stem cells labeled with quantum dots for quantitative in vivo three-dimensional fluorescence analysis. Stem Cells 25: 2128-2138, 2007.
18. Schuldt AJ, Rosen MR, Gaudette GR, Cohen IS. Repairing damaged myocardium: evaluating cells used for cardiac regeneration. Current Treat Opt Cardiovasc Med 10: 59-72, 2008.
19. Yu H, Gao J, Wang H, Wymore R, Steinberg S, McKinnon D, Rosen MR, Cohen IS. Effects of the renin-angiotensin system on the current Ito in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res 86: 1062-1068, 2000.