Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex

Protein Science

Volumn 21, Issue 10, 2012, Pages 1528-1539

  Niemann, Hartmut H ^a   Gherardi, Ermanno ^b   Bleymüller, Willem M ^a   Heinz, Dirk W ^c  

^a BIELEFELD UNIVERSITY   (Germany)

^b UNIVERSITY OF PAVIA   (Italy)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

c MET; Crystal packing; Crystal structure; Dimerization; Internalin B; Leucine rich repeat; Protein engineering; Protein protein interaction; Pseudo merohedral twinning; Receptor tyrosine kinase

Indexed keywords

CELL RECEPTOR; DIMER; HOST CELL RECEPTOR; INTERNALIN B; LEUCINE RICH REPEAT KINASE 2; SCATTER FACTOR RECEPTOR; SEMA PROTEIN; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BINDING AFFINITY; CELL INVASION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVATION; LEUCINE RICH REPEAT; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; WILD TYPE;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CRYSTALLOGRAPHY; HUMANS; LEUCINE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN ENGINEERING; PROTO-ONCOGENE PROTEINS C-MET; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES;

EID: 84866619718     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2142     Document Type: Article

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