Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes

Biochemical Pharmacology

Volumn 84, Issue 9, 2012, Pages 1133-1142

  Vizcaíno, Carolina ^a   Mansilla, Sylvia ^a   Núñez, Luz Elena ^b   Méndez, Carmen ^c   Salas, José A ^c   Morís, Francisco ^b   Portugal, José ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b Campus El Cristo   (Spain)

^c DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

Antitumor drugs; EC 8042; Gene expression; HCT116 cells; Mithramycin SK; Transcription factors

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; DEMYCAROSYL 3DELTA BETA DEXTRO DIGITOXOSYLMITHRAMYCIN SK; EC 8042; MITHRAMYCIN; MITHRAMYCIN SK; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; COLON CARCINOMA; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STUDENT T TEST; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; G1 PHASE CELL CYCLE CHECKPOINTS; G2 PHASE CELL CYCLE CHECKPOINTS; GENES, CDC; HCT116 CELLS; HUMANS; NECROSIS; PLICAMYCIN; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84866616340     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.08.003     Document Type: Article

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