Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway

FEBS Letters

Volumn 586, Issue 19, 2012, Pages 3485-3492

  Hu, Shao Yang ^a   Tai, Chen Chen ^b   Li, Yen Hsing ^b   Wu, Jen Leih ^b  

^a NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

C2C12 myoblast; IGF 1; Muscle hypertrophy; Progranulin; Signaling

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRANULIN; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN C2C12; CONTROLLED STUDY; GROWTH REGULATION; IMMUNOCYTOCHEMISTRY; MOUSE; MUSCLE GROWTH; MYOBLAST; MYOTUBE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; HYPERTROPHY; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, BIOLOGICAL; MUSCLE DEVELOPMENT; MUSCLE FIBERS, SKELETAL; MUSCULAR ATROPHY; MYOBLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84866602930     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.07.077     Document Type: Article

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