C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Zheng, Yanqiu ^a   Brady, Owen A ^a   Meng, Peter S ^a   Mao, Yuxin ^a   Hu, Fenghua ^a  

^a School of Integrative Plant Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTENSIN; PROGRANULIN; SORTILIN; GRN PROTEIN, HUMAN; SIGNAL PEPTIDE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE DELETION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; WESTERN BLOTTING;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL LINE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79958831842     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021023     Document Type: Article

References (23)

1. Neary D, Snowden J, Mann D, (2005) Frontotemporal dementia. Lancet Neurol 4: 771-780.
2. Ratnavalli E, Brayne C, Dawson K, Hodges JR, (2002) The prevalence of frontotemporal dementia. Neurology 58: 1615-1621.
3. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, et al. (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51: 1546-1554.
4. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, et al. (2006) Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442: 916-919.
5. Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, et al. (2006) Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 442: 920-924.
6. Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, et al. (2006) Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet 15: 2988-3001.
7. Bateman A, Bennett HP, (1998) Granulins: the structure and function of an emerging family of growth factors. J Endocrinol 158: 145-151.
8. Serrero G, (2003) Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis. Biochem Biophys Res Commun 308: 409-413.
9. He Z, Bateman A, (2003) Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med 81: 600-612.
10. Ryan CL, Baranowski DC, Chitramuthu BP, Malik S, Li Z, et al. (2009) Progranulin is expressed within motor neurons and promotes neuronal cell survival. BMC Neurosci 10: 130.
11. Pereson S, Wils H, Kleinberger G, McGowan E, Vandewoestyne M, et al. (2009) Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. J Pathol 219: 173-181.
12. Chen-Plotkin AS, Xiao J, Geser F, Martinez-Lage M, Grossman M, et al. (2010) Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathol 119: 111-122.
13. Yin F, Dumont M, Banerjee R, Ma Y, Li H, et al. (2010) Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. Faseb J 24: 4639-4647.
14. Yin F, Banerjee R, Thomas B, Zhou P, Qian L, et al. (2009) Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med 207: 117-128.
15. Laird AS, Van Hoecke A, De Muynck L, Timmers M, Van Den Bosch L, et al. (2010) Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy. PLoS One 5: e13368.
16. Hu F, Padukkavidana T, Vaegter CB, Brady OA, Zheng Y, et al. (2010) Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 68: 654-667.
17. Hermey G, (2009) The Vps10p-domain receptor family. Cell Mol Life Sci 66: 2677-2689.
18. Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, et al. (2010) Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma. Am J Hum Genet 87: 890-897.
19. Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, et al. (2007) Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci 10: 1449-1457.
20. Serup Andersen O, Boisguerin P, Glerup S, Skeldal S, Volkmer R, et al. (2010) Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding. J Biol Chem 285: 12210-12222.
21. Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, et al. (2011) The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332: 478-484.
22. Cashman NR, Durham HD, Blusztajn JK, Oda K, Tabira T, et al. (1992) Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Dev Dyn 194: 209-221.
23. Vancha AR, Govindaraju S, Parsa KV, Jasti M, Gonzalez-Garcia M, et al. (2004) Use of polyethyleneimine polymer in cell culture as attachment factor and lipofection enhancer. BMC Biotechnol 4: 23.