Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness

Journal of Biological Chemistry

Volumn 287, Issue 39, 2012, Pages 32747-32754

  Lalo, Ulyana ^a,b   Jones, Sarah ^a   Roberts, Jonathan A ^a   Mahaut Smith, Martyn P ^a   Evans, Richard J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOTIC; CELL SURFACE EXPRESSION; CLINICAL STUDY; GELDANAMYCIN; HEAT SHOCK PROTEIN; HEK293 CELLS; INTRACELLULAR CALCIUM; LOW DOSE; MOLECULAR CHAPERONES; P2X RECEPTORS; PHOTOACTIVATABLE; POTENTIAL EFFECTS; RADICICOL; REAL TIME; RECEPTOR CHIMERA; RECEPTOR TRAFFICKING; SELECTIVE INHIBITORS; TIME COURSE;

CELL MEMBRANES; COLLAGEN;

PLATELETS;

ADENOSINE TRIPHOSPHATE; CALCIUM ION; COLLAGEN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; RADICICOL; RECOMBINANT PROTEIN; RECOMBINANT PURINERGIC P2X1 RECEPTOR; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; EMBRYO; HEMOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; THROMBOCYTE;

ADENOSINE TRIPHOSPHATE; BENZOQUINONES; BLOOD PLATELETS; COLLAGEN; ENZYME INHIBITORS; FEMALE; HEK293 CELLS; HEMOSTASIS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MALE; PROTEIN TRANSPORT; RECEPTORS, PURINERGIC P2X1; RECEPTORS, PURINERGIC P2Y1;

EID: 84866564619     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.376566     Document Type: Article

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