Geldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation

Biochemical Journal

Volumn 345, Issue 2, 2000, Pages 307-314

  Suttitanamongkol, Sudawadee ^a   Gear, Adrian R L ^a   Polanowska Grabowska, Renata ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Heat shock protein; Herbimycin A; Tyrosine kinase inhibitor

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; ANTITHROMBOCYTIC AGENT; GELDANAMYCIN; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; ISOTOPE LABELING; MEMBRANE DAMAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCANNING ELECTRON MICROSCOPY; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE MEMBRANE;

ADENINE NUCLEOTIDES; BENZOQUINONES; BLOOD PLATELETS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; PHOSPHORYLATION; PLATELET AGGREGATION INHIBITORS; QUINONES; SEROTONIN; SIGNAL TRANSDUCTION; TYROSINE;

EID: 0034650725     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3450307     Document Type: Article

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