메뉴 건너뛰기




Volumn 21, Issue 10, 2012, Pages 1523-1534

Sclerostin monoclonal antibodies on bone metabolism and fracture healing

Author keywords

Bone; Density; Fixation; Fracture; Healing; Implant; Sclerostin

Indexed keywords

ALENDRONIC ACID; ANABOLIC AGENT; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PARATHYROID HORMONE; RECOMBINANT ANTIBODY; RECOMBINANT HORMONE; RECOMBINANT PROTEIN; ROMOSOZUMAB; SCLEROSTIN;

EID: 84866558030     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2012.713936     Document Type: Review
Times cited : (18)

References (70)
  • 2
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    • Lin C, Jiang X, Dai Z, et al. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 2009;24:1651-61
    • (2009) J Bone Miner Res , vol.24 , pp. 1651-1661
    • Lin, C.1    Jiang, X.2    Dai, Z.3
  • 4
    • 28744448698 scopus 로고    scopus 로고
    • Editorial: Sclerostin and Wnt Signaling - The pathway to bone strength
    • DOI 10.1210/jc.2005-2370
    • Ott SM. Sclerostin and Wnt signaling-the pathway to bone strength. J Clin Endocrinol Metab 2005;90:6741-3 (Pubitemid 41759344)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.12 , pp. 6741-6743
    • Ott, S.M.1
  • 6
    • 80053518269 scopus 로고    scopus 로고
    • Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    • Wijenayaka AR, Kogawa M, Lim HP, et al. Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway. PLoS ONE 2011;6:e25900
    • (2011) PLoS ONE , vol.6
    • Wijenayaka, A.R.1    Kogawa, M.2    Lim, H.P.3
  • 7
    • 84874411281 scopus 로고    scopus 로고
    • Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    • Wijenayaka A, Kogawa M, Findlay D, et al. Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway. ASBMR Annual Meeting Abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Wijenayaka, A.1    Kogawa, M.2    Findlay, D.3
  • 9
    • 81355127666 scopus 로고    scopus 로고
    • Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene
    • Li C, Ominsky MS, Tan HL, et al. Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene. Bone 2011;49:1178-85
    • (2011) Bone , vol.49 , pp. 1178-1185
    • Li, C.1    Ominsky, M.S.2    Tan, H.L.3
  • 10
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li X, Ominsky MS, Warmington KS, et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 2009;24:578-88
    • (2009) J Bone Miner Res , vol.24 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3
  • 11
    • 79961118892 scopus 로고    scopus 로고
    • Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone
    • Marenzana M, Greenslade K, Eddleston A, et al. Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone. Arthritis Rheum 2011;63:2385-95
    • (2011) Arthritis Rheum , vol.63 , pp. 2385-2395
    • Marenzana, M.1    Greenslade, K.2    Eddleston, A.3
  • 12
    • 70349920691 scopus 로고    scopus 로고
    • A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis
    • Eddleston A, Marenzana M, Moore AR, et al. A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis. J Bone Miner Res 2009;24:1662-71
    • (2009) J Bone Miner Res , vol.24 , pp. 1662-1671
    • Eddleston, A.1    Marenzana, M.2    Moore, A.R.3
  • 13
    • 77953481395 scopus 로고    scopus 로고
    • Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength
    • Ominsky MS, Vlasseros F, Jolette J, et al. Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res 2010;25:948-59
    • (2010) J Bone Miner Res , vol.25 , pp. 948-959
    • Ominsky, M.S.1    Vlasseros, F.2    Jolette, J.3
  • 14
    • 77956815310 scopus 로고    scopus 로고
    • Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats
    • Li X, Warmington KS, Niu QT, et al. Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats. J Bone Miner Res 2010;25:2647-56
    • (2010) J Bone Miner Res , vol.25 , pp. 2647-2656
    • Li, X.1    Warmington, K.S.2    Niu, Q.T.3
  • 15
    • 78650958526 scopus 로고    scopus 로고
    • Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • Padhi D, Jang G, Stouch B, et al. Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res 2011;26:19-26
    • (2011) J Bone Miner Res , vol.26 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3
  • 16
    • 77956822573 scopus 로고    scopus 로고
    • Sclerostin antibody treatment enhances metaphyseal bone healing in rats
    • Agholme F, Li X, Isaksson H, et al. Sclerostin antibody treatment enhances metaphyseal bone healing in rats. J Bone Miner Res 2010;25:2412-18
    • (2010) J Bone Miner Res , vol.25 , pp. 2412-2418
    • Agholme, F.1    Li, X.2    Isaksson, H.3
  • 17
    • 84862833571 scopus 로고    scopus 로고
    • Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats
    • Agholme F, Isaksson H, Li X, et al. Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats. Acta Orthop 2011;82:628-32
    • (2011) Acta Orthop , vol.82 , pp. 628-632
    • Agholme, F.1    Isaksson, H.2    Li, X.3
  • 20
    • 77950579909 scopus 로고    scopus 로고
    • Teriparatide improves early callus formation in distal radial fractures
    • Aspenberg P, Johansson T. Teriparatide improves early callus formation in distal radial fractures. Acta Orthop 2010;81:234-6
    • (2010) Acta Orthop , vol.81 , pp. 234-236
    • Aspenberg, P.1    Johansson, T.2
  • 21
    • 77953473271 scopus 로고    scopus 로고
    • Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures
    • Aspenberg P, Genant HK, Johansson T, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res 2010;25:404-14
    • (2010) J Bone Miner Res , vol.25 , pp. 404-414
    • Aspenberg, P.1    Genant, H.K.2    Johansson, T.3
  • 22
    • 79955635177 scopus 로고    scopus 로고
    • Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
    • Ominsky MS, Li C, Li X, et al. Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones. J Bone Miner Res 2011;26:1012-21
    • (2011) J Bone Miner Res , vol.26 , pp. 1012-1021
    • Ominsky, M.S.1    Li, C.2    Li, X.3
  • 25
    • 0041630893 scopus 로고    scopus 로고
    • The natural history of sclerosteosis
    • DOI 10.1034/j.1399-0004.2003.00036.x
    • Hamersma H, Gardner J, Beighton P. The natural history of sclerosteosis. Clin Genet 2003;63:192-7 (Pubitemid 36949919)
    • (2003) Clinical Genetics , vol.63 , Issue.3 , pp. 192-197
    • Hamersma, H.1    Gardner, J.2    Beighton, P.3
  • 28
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling AG, Niziolek PJ, Baldridge LA, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008; 283:5866-75
    • (2008) J Biol Chem , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3
  • 29
    • 84874420098 scopus 로고    scopus 로고
    • Bone volume is not altered with unloading in the homozygous sclerostin knockout mouse
    • Morse A, McDonald MM, Kramer I, et al. Bone volume is not altered with unloading in the homozygous sclerostin knockout mouse. ORS Annual Meeting; 2012
    • (2012) ORS Annual Meeting
    • Morse, A.1    McDonald, M.M.2    Kramer, I.3
  • 30
    • 84865490988 scopus 로고    scopus 로고
    • Strongly enhanced levels of sclerostin during human fracture healing
    • [Epub ahead of print]
    • Sarahrudi K, Thomas A, Albrecht C, et al. Strongly enhanced levels of sclerostin during human fracture healing. J Orthop Res 2012. [Epub ahead of print]
    • (2012) J Orthop Res
    • Sarahrudi, K.1    Thomas, A.2    Albrecht, C.3
  • 31
    • 84874401909 scopus 로고    scopus 로고
    • Sclerostin antibody prevents bone loss and increases bone formation in female rats with high turnover due to ovariectomy
    • Li X, Warmington S, Xia XC, et al. Sclerostin antibody prevents bone loss and increases bone formation in female rats with high turnover due to ovariectomy. ASBMR Annual Meeting Abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Li, X.1    Warmington, S.2    Xia, X.C.3
  • 32
    • 84874430068 scopus 로고    scopus 로고
    • Sclerostin inhibition by monoclonal antibody reversed trabecular and cortical bone loss in orchiectomized rats with established osteopenia
    • Li X, Warmington KS, Niu Q-T, et al. Sclerostin Inhibition by Monoclonal Antibody Reversed Trabecular and Cortical Bone Loss in Orchiectomized Rats with Established Osteopenia. ASBMR Annual Meeting Abstracts; 2010
    • (2010) ASBMR Annual Meeting Abstracts
    • Li, X.1    Warmington, K.S.2    Niu, Q.-T.3
  • 33
    • 84874408817 scopus 로고    scopus 로고
    • Treatment with a sclerostin antibody increased osteoblast-derived markers of bone formation and decreased osteoclast-related markers of bone resortion in ovariectomised rats
    • Stolina M, Dwyer D, Niu Q-T, et al. Treatment With a Sclerostin Antibody Increased Osteoblast-derived Markers of Bone Formation and Decreased Osteoclast-related Markers of Bone Resortion in Ovariectomised Rats. ASBMR Annual Meeting Abstracts; 2010
    • (2010) ASBMR Annual Meeting Abstracts
    • Stolina, M.1    Dwyer, D.2    Niu, Q.-T.3
  • 34
    • 78650074746 scopus 로고    scopus 로고
    • Sclerostin monoclonal antibody therapy with AMG 785: A potential treatment for osteoporosis
    • Lewiecki EM. Sclerostin monoclonal antibody therapy with AMG 785: a potential treatment for osteoporosis. Expert Opin Biol Ther 2011;11:117-27
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 117-127
    • Lewiecki, E.M.1
  • 35
    • 0033042160 scopus 로고    scopus 로고
    • Anabolic effects of human biosynthetic parathyroid hormone fragment (1- 34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits
    • Hirano T, Burr DB, Turner CH, et al. Anabolic effects of human biosynthetic parathyroid hormone fragment (1-34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits. J Bone Miner Res 1999;14:536-45 (Pubitemid 29153386)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.4 , pp. 536-545
    • Hirano, T.1    Burr, D.B.2    Turner, C.H.3    Sato, M.4    Cain, R.L.5    Hock, J.M.6
  • 36
    • 0035158179 scopus 로고    scopus 로고
    • Intermittently administered human parathyroid hormone(1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys
    • Burr DB, Hirano T, Turner CH, et al. Intermittently administered human parathyroid hormone(1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys. J Bone Miner Res 2001;16:157-65 (Pubitemid 32046201)
    • (2001) Journal of Bone and Mineral Research , vol.16 , Issue.1 , pp. 157-165
    • Burr, D.B.1    Hirano, T.2    Turner, C.H.3    Hotchkiss, C.4    Brommage, R.5    Hock, J.M.6
  • 37
    • 84857442198 scopus 로고    scopus 로고
    • Sclerostin levels during growth in children
    • Kirmani S, Amin S, McCready LK, et al. Sclerostin levels during growth in children. Osteoporos Int 2012;23:1123-30
    • (2012) Osteoporos Int , vol.23 , pp. 1123-1130
    • Kirmani, S.1    Amin, S.2    McCready, L.K.3
  • 38
    • 78650983826 scopus 로고    scopus 로고
    • Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model
    • Tian X, Jee WS, Li X, et al. Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model. Bone 2011;48:197-201
    • (2011) Bone , vol.48 , pp. 197-201
    • Tian, X.1    Jee, W.S.2    Li, X.3
  • 39
    • 80052478948 scopus 로고    scopus 로고
    • Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats
    • Li X, Ominsky MS, Warmington KS, et al. Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats. Endocrinology 2011;152:3312-22
    • (2011) Endocrinology , vol.152 , pp. 3312-3322
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3
  • 40
    • 84874399401 scopus 로고    scopus 로고
    • Phase 2 Study of AMG 785 in Postmenopausal Women With Low Bone Mineral Density
    • Phase 2 Study of AMG 785 in Postmenopausal Women With Low Bone Mineral Density. Available from: http://clinicaltrials.gov/ct2/show/NCT00896532
  • 41
    • 84874408722 scopus 로고    scopus 로고
    • A Study to Evaluate the Effect of AMG 785 on Bone Quality of the Forearm in Postmenopausal Women With Low Bone Mass
    • A Study to Evaluate the Effect of AMG 785 on Bone Quality of the Forearm in Postmenopausal Women With Low Bone Mass. Available from: http:// clinicaltrials. gov/ct2/show/NCT00950950
  • 42
    • 84874440434 scopus 로고    scopus 로고
    • Enhanced peri-implant bone formation and fixation by sclerostin antibody in a rat ovariectomy model
    • Virdi A, Sena K, Liu M, et al. Enhanced Peri-Implant Bone Formation and Fixation by Sclerostin Antibody in a Rat Ovariectomy Model. ASBMR Annual Meeting Abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Virdi, A.1    Sena, K.2    Liu, M.3
  • 43
    • 84874440111 scopus 로고    scopus 로고
    • Sclerostin antibody increases peri-implant bone formation in sham-ovariectomised and ovariectomised rats
    • Sena K, Liu M, Ke HZ, et al. Sclerostin Antibody Increases Peri-implant Bone Formation in Sham-ovariectomised and Ovariectomised Rats. ASBMR Annual Meeting Abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Sena, K.1    Liu, M.2    Ke, H.Z.3
  • 44
    • 84874434199 scopus 로고    scopus 로고
    • Bone implant fixation augmentation with anti-sclerostin antibody treatment in rats
    • Virdi A, Sena K, Maletich J, et al. Bone implant fixation augmentation with anti-sclerostin antibody treatment in rats. J Bone Miner Res 2009;24:S375
    • (2009) J Bone Miner Res , vol.24
    • Virdi, A.1    Sena, K.2    Maletich, J.3
  • 45
    • 84874439572 scopus 로고    scopus 로고
    • Sclerostin antibody enhances bone-implant contact by increasing bone formation and inhibiting bone resorption
    • Irish JM, Virdi AS, Sena K, et al. Sclerostin Antibody Enhances Bone-Implant Contact by Increasing Bone Formation and Inhibiting Bone Resorption. ORS Annual Meeting; 2012
    • (2012) ORS Annual Meeting
    • Irish, J.M.1    Virdi, A.S.2    Sena, K.3
  • 46
    • 84874418841 scopus 로고    scopus 로고
    • Treatment with sclerostin antibody increases bone mass and strength during hindlimb unloading
    • Spatz J, Ellman R, Cloutier AM, et al. Treatment with Sclerostin Antibody Increases Bone Mass and Strength During Hindlimb Unloading. ASBMR Annual Meeting abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Spatz, J.1    Ellman, R.2    Cloutier, A.M.3
  • 47
    • 74949103626 scopus 로고    scopus 로고
    • Inhibition of sclerostin by systemic treatment with a sclerostin monoclonal antibody enhances fracture healing in mice and rats
    • Ke HZ, Xiang JJ, Li X, et al. Inhibition of sclerostin by systemic treatment with a sclerostin monoclonal antibody enhances fracture healing in mice and rats. Trans Orthop Res Soc 2009;34:221
    • (2009) Trans Orthop Res Soc , vol.34 , pp. 221
    • Ke, H.Z.1    Xiang, J.J.2    Li, X.3
  • 48
    • 84874414181 scopus 로고    scopus 로고
    • Inhibition of sclerostin by monoclonal antibody enhances bone healing in rat osteotomy model
    • He YX, Liu Z, Man CW, et al. Inhibition of Sclerostin by Monoclonal Antibody Enhances Bone Healing in rat Osteotomy Model. ORS Annual Meeting; 2012
    • (2012) ORS Annual Meeting
    • He, Y.X.1    Liu, Z.2    Man, C.W.3
  • 49
    • 84874447113 scopus 로고    scopus 로고
    • Influence of sclerostin antibody on bone repair in a rat femoral defect model
    • Virk M, Saquib S, Farhang A, et al. Influence of sclerostin antibody on bone repair in a rat femoral defect model. Trans Orthop Res Soc 2009;34:607
    • (2009) Trans Orthop Res Soc , vol.34 , pp. 607
    • Virk, M.1    Saquib, S.2    Farhang, A.3
  • 50
    • 84874423032 scopus 로고    scopus 로고
    • Sclerostin antibody enhances bone repair in a rat femoral defect model
    • Alaee F, Tang A, Ominsky M, et al. Sclerostin Antibody Enhances Bone Repair in a Rat Femoral Defect Model. ASBMR Annual Meeting Abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Alaee, F.1    Tang, A.2    Ominsky, M.3
  • 51
    • 84874448023 scopus 로고    scopus 로고
    • Inhibition of sclerostin by monoclonal antibody enhances bone healing in a rat osteotomy model
    • [Epub ahead of print]
    • He Y, Liu Z, Tang T, et al. Inhibition of Sclerostin by Monoclonal Antibody Enhances Bone Healing in a Rat Osteotomy Model. ASBMR Annual Meeting Abstracts; 2011. [Epub ahead of print]
    • (2011) ASBMR Annual Meeting Abstracts
    • He, Y.1    Liu, Z.2    Tang, T.3
  • 52
    • 84865509876 scopus 로고    scopus 로고
    • Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats
    • McDonald MM, Morse A, Mikulec K, et al. Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats. J Orthop Res 2012
    • (2012) J Orthop Res
    • McDonald, M.M.1    Morse, A.2    Mikulec, K.3
  • 53
    • 84874446214 scopus 로고    scopus 로고
    • Study of AMG 785 in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing
    • Study of AMG 785 in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing. Available from: http://clinicaltrials.gov/ct2/show/ NCT00907296
  • 54
    • 84874443760 scopus 로고    scopus 로고
    • Study To Assess Fracture Healing With Sclerostin Antibody
    • Study To Assess Fracture Healing With Sclerostin Antibody. Available from: http://clinicaltrials.gov/ct2/show/NCT01081678
  • 55
    • 34248151930 scopus 로고    scopus 로고
    • Biological options to enhance periprosthetic bone mass
    • DOI 10.1016/j.injury.2007.02.051, PII S002013830700099X, Periprosthetic Femoral Fractures
    • Tsiridis E, Gamie Z, Conaghan PG, et al. Biological options to enhance periprosthetic bone mass. Injury 2007;38:704-13 (Pubitemid 46726314)
    • (2007) Injury , vol.38 , Issue.6 , pp. 704-713
    • Tsiridis, E.1    Gamie, Z.2    Conaghan, P.G.3    Giannoudis, P.V.4
  • 58
    • 84874402898 scopus 로고    scopus 로고
    • Infrequent co-treatment and sequential treatment of anti-sclerostin antibody with zoledronic acid restores and maintains bone mass in murine osteoporosis models
    • Halleux C, Hu S, Prassler J, et al. Infrequent Co-treatment and Sequential Treatment of Anti-sclerostin Antibody with Zoledronic Acid Restores and Maintains Bone Mass in Murine Osteoporosis Models. Proceedings of the ASBMR Annual Meeting; 2009
    • (2009) Proceedings of the ASBMR Annual Meeting
    • Halleux, C.1    Hu, S.2    Prassler, J.3
  • 59
    • 77957581401 scopus 로고    scopus 로고
    • Nonoperative fracture treatment in the modern era
    • Court-Brown CM, Aitken S, Hamilton TW, et al. Nonoperative fracture treatment in the modern era. J Trauma 2010;69:699-707
    • (2010) J Trauma , vol.69 , pp. 699-707
    • Court-Brown, C.M.1    Aitken, S.2    Hamilton, T.W.3
  • 60
    • 33744992495 scopus 로고    scopus 로고
    • Osteoporosis
    • DOI 10.1016/S0140-6736(06)68891-0, PII S0140673606688910
    • Sambrook P, Cooper C. Osteoporosis. Lancet 2006;367:2010-18 (Pubitemid 43867702)
    • (2006) Lancet , vol.367 , Issue.9527 , pp. 2010-2018
    • Sambrook, P.1    Cooper, C.2
  • 62
    • 61449426235 scopus 로고    scopus 로고
    • Targeting bone morphogenetic protein antagonists: In vitro and in vivo evidence of their role in bone metabolism
    • Tsialogiannis E, Polyzois I, Oak Tang Q, et al. Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism. Expert Opin Ther Targets 2009;13:123-37
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 123-137
    • Tsialogiannis, E.1    Polyzois, I.2    Oak Tang, Q.3
  • 63
    • 84874412790 scopus 로고    scopus 로고
    • Sclerostin antibody enhances spine fusion in a rat posterolateral transverse process fusion model: Preliminary results
    • Shaffer A, Shonuga OA, Hirsch B, et al. Sclerostin Antibody Enhances Spine Fusion in a Rat Posterolateral Transverse Process Fusion Model: Preliminary Results. ASBMR Annual Meeting Abstracts; 2011
    • (2011) ASBMR Annual Meeting Abstracts
    • Shaffer, A.1    Shonuga, O.A.2    Hirsch, B.3
  • 64
    • 84874447073 scopus 로고    scopus 로고
    • Anti-sclerostin (Scl-Ab) increases bone mass and fusion volume in a rat posterolateral spinal fusion model
    • Shaffer AD, Shonuga OA, Hirsch BP, et al. Anti-Sclerostin (Scl-Ab) Increases Bone Mass and Fusion Volume in a Rat Posterolateral Spinal Fusion Model. ORS Annual Meeting; 2012
    • (2012) ORS Annual Meeting
    • Shaffer, A.D.1    Shonuga, O.A.2    Hirsch, B.P.3
  • 65
    • 41149140398 scopus 로고    scopus 로고
    • Bisphosphonates can block the deterioration in implant fixation after withdrawal of intermittent doses of parathyroid hormone
    • DOI 10.1302/0301-620X.90B3.19544
    • Johansson HR, Skripitz R, Aspenberg P. Bisphosphonates can block the deterioration in implant fixation after withdrawal of intermittent doses of parathyroid hormone. J Bone Joint Surg Br 2008;90:400-4 (Pubitemid 351428963)
    • (2008) Journal of Bone and Joint Surgery - Series B , vol.90 , Issue.3 , pp. 400-404
    • Johansson, H.R.1    Skripitz, R.2    Aspenberg, P.3
  • 66
    • 0035041898 scopus 로고    scopus 로고
    • Implant fixation enhanced by intermittent treatment with parathyroid hormone
    • Skripitz R, Aspenberg P. Implant fixation enhanced by intermittent treatment with parathyroid hormone. J Bone Joint Surg Br 2001;83:437-40 (Pubitemid 32390361)
    • (2001) Journal of Bone and Joint Surgery - Series B , vol.83 , Issue.3 , pp. 437-440
    • Skripitz, R.1    Aspenberg, P.2
  • 67
    • 79953299174 scopus 로고    scopus 로고
    • Teriparatide in the treatment of a loose hip prosthesis
    • Zati A, Sarti D, Malaguti MC, et al. Teriparatide in the treatment of a loose hip prosthesis. J Rheumatol 2011;38:778-80
    • (2011) J Rheumatol , vol.38 , pp. 778-780
    • Zati, A.1    Sarti, D.2    Malaguti, M.C.3
  • 68
    • 80052800133 scopus 로고    scopus 로고
    • Teriparatide (rh [1-34] PTH) improved osteointegration of a hemiarthroplasty with signs of aseptic loosening
    • Oteo-Alvaro A, Matas JA, Alonso-Farto JC. Teriparatide (rh [1-34] PTH) improved osteointegration of a hemiarthroplasty with signs of aseptic loosening. Orthopedics 2011;34:e574-7
    • (2011) Orthopedics , vol.34
    • Oteo-Alvaro, A.1    Matas, J.A.2    Alonso-Farto, J.C.3
  • 69
    • 65249167488 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
    • Kansara M, Tsang M, Kodjabachian L, et al. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest 2009;119:837-51
    • (2009) J Clin Invest , vol.119 , pp. 837-851
    • Kansara, M.1    Tsang, M.2    Kodjabachian, L.3
  • 70
    • 84866540283 scopus 로고    scopus 로고
    • Increased subchondral bone mass with no histological changes in articular cartilage in sclerostin knockout mice and rats treated with sclerostin monoclonal antibody
    • Niu Q-T, Li X, Ke HZ. Increased Subchondral Bone Mass with No Histological Changes in Articular Cartilage in Sclerostin Knockout Mice and Rats Treated with Sclerostin Monoclonal Antibody. ORS Annual Meeting; 2012
    • (2012) ORS Annual Meeting
    • Niu, Q.-T.1    Li, X.2    Ke, H.Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.