Mechanistic studies on the release of lysozyme from twin-screw extruded lipid implants

Journal of Controlled Release

Volumn 163, Issue 2, 2012, Pages 187-194

  Sax, Gerhard ^a   Winter, Gerhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Extrusion; Lipid implants; Polyethylene glycol; Protein; Sustained release; Triglycerides

Indexed keywords

DRUG RELEASE; IMPLANT MATRIX; IN-VITRO; IN-VIVO; LOW MELTING; MAJOR FACTORS; MECHANISTIC STUDIES; MODEL PROTEINS; MODERATE TEMPERATURE; PARTIAL MATRIX; PARTIAL MELTING; PORE-FORMING AGENTS; PROTEIN RELEASE; RELEASE KINETICS; RELEASE PROFILES; SUSTAINED RELEASE; TRIGLYCERIDES; TRISTEARIN; TWIN SCREW EXTRUSION;

BIODEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG PRODUCTS; ENZYMES; EXTRUSION; GLYCEROL; POLYETHYLENE GLYCOLS; PROTEINS; SCANNING ELECTRON MICROSCOPY; SCREWS; X RAY DIFFRACTION;

MELTING;

GLYCEROL TRISTEARIN; LIPID; LYSOZYME; MACROGOL 4000; MACROGOL 6000; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DEAMINATION; DEGRADATION KINETICS; DIFFERENTIAL SCANNING CALORIMETRY; IMPLANT; LIPID ANALYSIS; OXIDATION KINETICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TEMPERATURE MEASUREMENT; TWIN SCREW EXTRUSION; X RAY DIFFRACTION;

DRUG IMPLANTS; EXCIPIENTS; MURAMIDASE; POLYETHYLENE GLYCOLS; TEMPERATURE; TRIGLYCERIDES;

EID: 84866531255     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.025     Document Type: Article

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