Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 295-302

  Sax, Gerhard ^a   Feil, Florian ^a   Schulze, Sandra ^a   Jung, Christophe ^a   Bräuchle, Christoph ^a   Winter, Gerhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Extrusion; Lipid implants; Polyethylene glycol; Protein; Sustained release; Triglycerides

Indexed keywords

CONCENTRATED SOLUTION; CONTROL MEASUREMENTS; EXTRUDATES; FLUORESCENT DYES; INDIVIDUAL PROTEINS; LABELED PROTEINS; LIPID MATRIX; MELTING RANGE; MODERATE TEMPERATURE; PORE-FORMING AGENTS; SINGLE PARTICLE TRACKING; SINGLE-MOLECULE FLUORESCENCE MICROSCOPY; SINGLE-MOLECULE MICROSCOPY; SUSTAINED RELEASE; TRIGLYCERIDES; TWIN SCREW; TWIN SCREW EXTRUSION; WATER-FILLED PORES; WATERSOLUBLE;

ANTIBIOTICS; DIFFUSION; EXTRUSION; FLUORESCENCE MICROSCOPY; GLYCOPROTEINS; ORGANIC SOLVENTS; POLYETHYLENE GLYCOLS; PROTEINS;

MOLECULES;

ALPHA2A INTERFERON; FLUORESCENT DYE; LIPID; MACROGOL 6000; ORGANIC SOLVENT; TRIACYLGLYCEROL;

ARTICLE; DIFFUSION; DISPERSION; DISSOLUTION; FLUORESCENCE MICROSCOPY; MELTING POINT; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SINGLE MOLECULE FLUORESCENCE MICROSCOPY; SUSTAINED DRUG RELEASE; TEMPERATURE;

DRUG COMPOUNDING; DRUG IMPLANTS; FLUORESCENT DYES; INTERFERON-ALPHA; MICROSCOPY, FLUORESCENCE; RECOMBINANT PROTEINS; TRIGLYCERIDES;

EID: 84865333653     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.014     Document Type: Article

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