Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat

Expert Opinion on Drug Metabolism and Toxicology

Volumn 8, Issue 10, 2012, Pages 1223-1230

  Delgado, Teresa C ^b   Barosa, Cristina ^a   Nunes, Patrícia M ^a   Scott, Donald K ^c   O'Doherty, Robert M ^c   Cerdán, Sebastián ^b   Geraldes, Carlos Fgc ^a   Jones, John G ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cyclosporine A; de novo lipogenesis; Endogenous glucose production; Insulin resistance; Liver; Post transplant diabetes mellitus

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CYCLOSPORIN A; DEUTERIUM OXIDE; FATTY ACID SYNTHASE; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DEUTERON NUCLEAR MAGNETIC RESONANCE; DIABETES MELLITUS; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLYCOGENOLYSIS; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER; MALE; NONHUMAN; RAT;

ANIMALS; BLOOD GLUCOSE; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLYCOGENOLYSIS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 84866515605     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2012.709500     Document Type: Article

References (38)

1. Vincenti F, Friman S, Scheuermann E, et al. Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. Am J Transplant 2007;7(6):1506-14 (Pubitemid 46776239)
2. Weir M. Impact of immunosuppressive regimes on posttransplant diabetes mellitus. Transplant Proc 2001;33(5A Suppl):23S-26S (Pubitemid 33767088)
3. Akhlaghi F, Trull AK. Distribution of cyclosporin in organ transplant recipients. Clin Pharmacokinet 2002;41(9):615-37
4. Nielsen JH, Mandruppoulsen T, Nerup J. Direct effects of cyclosporine-A on human pancreatic beta-cells. Diabetes 1986;35(9):1049-52 (Pubitemid 16029828)
5. Drachenberg CB, Klassen DK, Wiland A, et al. Islet cell damage associated with tacrolimus and cyclosporine. Morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 1999;67(7):S209-S
6. Hjelmesaeth J, Hagen LT, Asberg A, et al. The impact of short-term ciclosporin A treatment on insulin secretion and insulin sensitivity in man. Nephrol Dial Transpl 2007;22(6):1743-9 (Pubitemid 47073778)
7. Yale JF, Chamelian M, Courchesne S, Vigeant C. Peripheral insulin resistance and decreased insulin-secretion after cyclosporine-A treatment. Transplant P 1988;20(3):985-8
8. Ozbay LA, Smidt K, Mortensen DM, et al. Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS-1E beta-cells. Br J Pharmacol 2011;162(1):136-46
9. Vaziri ND, Liang KH, Azad H. Effect of cyclosporine on HMG-CoA reductase, cholesterol 7 alpha-hydroxylase, LDL receptor, HDL receptor, VLDL receptor, and lipoprotein lipase expressions. J Pharmacol Exp Ther 2000;294(2):778-83 (Pubitemid 30490857)
10. Boden G, Chen X, Ruiz J, et al. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994;93(6):2438-46 (Pubitemid 24177157)
11. Wahlstrom HE, Lavellejones M, Endres D, et al. Inhibition of insulin release by cyclosporine and production of peripheral insulin resistance in the dog. Transplantation 1990;49(3):600-4 (Pubitemid 20110482)
12. Ikeuchi M, Kida K, Goto Y, et al. In vivo and in vitro effects of cyclosporin A on glucose transport by soleus muscles of mice. Biochem Pharmacol 1992;43(7):1459-63
13. Midtvedt K, Hjelmesaeth J, Hartmann A, et al. Insulin resistance after renal transplantation: The effect of steroid dose reduction and withdrawal. J Am Soc Nephrol 2004;15(12):3233-9 (Pubitemid 39578856)
14. Delgado TC, Barosa C, Nunes PM, et al. Resolving the sources of plasma glucose excursions following a glucose tolerance test in the rat, deuterated water, glucose. PLoS One 2012;7(3):e34042
15. Mazzoni G, Mazzoni P. Reversibility of graft rejection following a short cyclosporin-A administration 5 days after grafting. Microsurgery 1986;7(3):114-16 (Pubitemid 17194105)
16. Tuglular S, Gogas Yavuz D, Cakalagaoglu F, et al. Cyclosporine-A induced nephrotoxicity is associated with decreased renal bone morphogenetic protein-7 expression in rats. Transplant Proc 2004;36(1):131-3 (Pubitemid 38177211)
17. Suga M, Gladdy R, Xing Z, et al. Transplant immunosuppression enhances efficiency of adenoviral-mediated gene retransfection: Inhibition of interferon-gamma and immunoglobin G. Ann Thorac Surg 2002;73(4):1092-7 (Pubitemid 34275885)
18. Brunner LJ, Bennett WM, Koop DR. Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner. Kidney Int 1998;54(1):216-23 (Pubitemid 28288038)
19. Jin ES, Uyeda K, Kawaguchi T, et al. Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis. J Biol Chem 2003;278(31):28427-33 (Pubitemid 36935744)
20. Jones JG, Solomon MA, Cole SM, et al. An integrated 2H and 13C NMR study of gluconeogenesis and TCA cycle flux in humans. Am J Physiol Endocrinol Metab 2001;281(4):E848-56
21. Jones JG, Merritt M, Malloy C. Quantifying tracer levels of 2H2O enrichment from microliter amounts of plasma and urine by 2H NMR. Magn Reson Med 2001;45(1):156-8 (Pubitemid 32044276)
22. Soares AF, Viega FJ, Carvalho RA, Jones JG. Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions. Magn Reson Med 2009;61(1):1-5
23. Soares AF, Carvalho RA, Veiga FJ, Jones JG. Effects of galactose on direct and indirect pathway estimates of hepatic glycogen synthesis. Metab Eng 2010;12(6):552-60
24. Perdigoto R, Rodrigues TB, Furtado AL, et al. Integration of [U-13C]glucose and 2H2O for quantification of hepatic glucose production and gluconeogenesis. NMR Biomed 2003;16(4):189-98 (Pubitemid 37265322)
25. Nunes PM, Carvalho E, Jones JG. Elimination of glucose contamination from adipocyte glycogen extracts. Carbohydr Res 2008;343(9):1486-9
26. Kneteman NM, Marchetti P, Tordjman K, et al. Effects of cyclosporine on insulin secretion and insulin sensitivity in dogs with intrasplenic islet autotransplants. Surgery 1992;111(4):430-7
27. Wang Y, Perfetti R, Greig NH, et al. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats. J Clin Invest 1997;99(12):2883-9 (Pubitemid 27278664)
28. Cruciani-Guglielmacci C, Vincent-Lamon M, Rouch C, et al. Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone. Am J Physiol Endocrinol Metab 2005;288(1):E148-54 (Pubitemid 40023801)
29. Wajngot A, Chandramouli V, Schumann WC, et al. Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus. Metabolism 2001;50(1):47-52 (Pubitemid 32058548)
30. Moore MC, Cherrington AD, Palmer B, et al. Disposition of a mixed meal by conscious dogs after seven days of treatment with cyclosporine A and prednisone. J Parenter Enteral Nutr 2000;24(4):244-50
31. Jiang G, Zhang BB. Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab 2003;284(4):E671-8 (Pubitemid 36323859)
32. Martin F, Bedoya FJ. Mechanisms of action of cyclosporin A on islet alpha- and beta-cells. Effects on cAMP- and calcium-dependent pathways. Life Sci 1991; 49(25):1915-21
33. Serkova N, Klawitter J, Niemann CU. Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat. Transplant Int 2003;16(10):748-55 (Pubitemid 37408597)
34. Riegel W, Stephan E, Balle C, et al. Effect of cyclosporin A on carbohydrate metabolism of isolated rat liver cells. Kidney Int Suppl 1989;27:S236-8
35. Delgado TC, Barosa C, Castro MM, et al. Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment. Magn Reson Med 2008;60(3):517-23
36. Brown MS, Goldstein JL. Selective versus total insulin resistance: A pathogenic paradox. Cell Metab 2008;7(2):95-6 (Pubitemid 351168559)
37. Wu J, Zhu YH, Patel SB. Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2. Am J Physiol 1999;277(6 Pt 1):E1087-94 (Pubitemid 30046004)
38. Torras J, Herrero I, Castells A, et al. Effect of ciclosporin on serum lipids and modification with LSL 90202, a lysine salt of eicosapentaenoic acid. Nephron 1995;69(3):318-22