Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions

Magnetic Resonance in Medicine

Volumn 61, Issue 1, 2009, Pages 1-5

  Soares, Ana F ^a,b   Viega, Francisco J ^a   Carvalho, Rui A ^b   Jones, John G ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Deuterated water; Diabetes; Direct pathway; Glycogen synthesis; Liver

Indexed keywords

FEEDING; HYDROGEN; LIVER; MEDICAL PROBLEMS;

AD LIBITUM; BLOOD GLUCOSE; DEUTERATED WATER; DIRECT PATHWAY; FEEDING CONDITIONS; GLYCOGEN SYNTHESIS; PATHOPHYSIOLOGY; STREPTOZOTOCIN;

RATS;

GLUCOSE; GLYCOGEN; HYDROGEN; STREPTOZOCIN; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DEUTERON NUCLEAR MAGNETIC RESONANCE; FEEDING; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; GLYCOGEN SYNTHESIS; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PATHOPHYSIOLOGY; RAT;

EID: 60349107143     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21830     Document Type: Article

References (25)

1. Newgard CB, Hixsch LJ, Foster DW, McGarry JD. Hepatic glycogen- synthesis in the rat-a direct or an indirect pathway. Fed Proc 1983; 42:2166-2166.
2. Newgard CB, Moore SV, Foster DW, McGarry JD. Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. J Biol Chem 1984;259:6958-6963.
3. Magnusson I, Chandramouli V, Schumann WC, Kumaran K, Wahren J, Landau BR. Pathways of hepatic glycogen formation in humans following ingestion of a glucose load in the fed state. Metab Clin Exp 1989; 38:583-585.
4. Shulman GI, Cline G, Schumann WC, Chandramouli V, Kumaran K, Landau BR. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans. Am J Physiol Endocrinol Metab 1990;259:E335-E341.
5. Hellerstein MK, Xie Y. The indirect pathway of hepatic glycogen synthesis and reduction of food intake by metabolic inhibitors. Life Sci 1993;53:1833-1845.
6. Magnusson I, Chandramouli V, Schumann WC, Kumaran K, Wahren J, LandauBR. Quantitationofthe pathways ofhepatic glycogenformation on ingesting a glucose load. J Clin Invest 1987;80:1748-1754.
7. Bischof MG, Bernroider E, Krssak M, Krebs M, Stingl H, Nowotny P, Yu C, Shulman GI, Waldhausl W, Roden M. Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia. Diabetes 2002; 51:49-54.
8. 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeosta- sis after a mixed meal in normal subjects. J Clin Invest 1996;97:126-132.
9. Benavides A, Siches M, Llobera M. Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat. Am J Physiol Regul Integr Comp Physiol 1998;275:R811-817.
10. 13C]glucose in rats. J Biol Chem 1989;264:12994-13004.
11. Newgard CB, Hirsch LJ, Foster DW, McGarry JD. Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? J Biol Chem 1983;258:8046-8052.
12. Shulman GI, Rothman DL, Smith D, Johnson CM, Blair JB, Shulman RG, DeFronzo RA. Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. J Clin Invest 1985;76:1229-1236.
13. MacQueen HA, Sadler DA, Moore SA, Daya S, Brown JY, Shuker DEG, Seaman M, Wassif WS. Deleterious effects of a cafeteria diet on the livers of nonobese rats. Nutr Res 2007;27:38-47.
14. Gaiva MH, Couto RC, Oyama LM, Couto GEC, Silveira VLF, Ribeiro EB, Nascimento CMO. Diets rich in polyunsaturated fatty acids: effect on hepatic metabolism in rats. Nutrition 2003;19:144-149.
15. Jones JG, Fagulha A, Barosa C, Bastos M, Barros L, Baptista C, Caldeira MM, Carvalheiro M. Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen. Diabetes 2006;55:2294-2300.
16. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC. Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 1996;98:378-385.
17. 13C enrichment of human glucuronide from metabolic tracers. J Carb Chem 2006;25:203-217.
18. 2H NMR. Magn Reson Med 2001;45:156-158.
19. Sena CM, Barosa C, Nunes E, Seiga R, Jones JG. Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat. Diabetes Metab 2007;33:296-302.
20. Jin ES, Burgess SC, Merritt ME, Sherry AD, Malloy CR. Differing mechanisms of hepatic glucose overproduction in triiodothyro- nine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose. Am J Physiol Endocrinol Metab 2005;288:E654- 662.
21. 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry. Anal Biochem 2003;318:321-324.
22. Rognstad R, Katz J, Clark DG. Glucose synthesis in tritiated water. Eur J Biochem 1974;47:383-388.
23. Postle AD, Bloxham DP. The use of tritiated water to measure absolute rates of hepatic glycogen synthesis. Biochem J 1980;192:65-73.
24. 2O to measure gluconeogenesis in humans. Diabetes 2008;57:50-55.
25. 2O. In: Roden M, editor. Clinical diabetes research: methods and techniques. London: Wiley-Blackwell Press; 2007. p 139-149.