Transplant immunosuppression enhances efficiency of adenoviral-mediated gene retransfection: Inhibition of interferon-γ and immunoglobin G

Annals of Thoracic Surgery

Volumn 73, Issue 4, 2002, Pages 1092-1097

  Suga, Michiharu ^b   Gladdy, Rebecca ^b   Xing, Zhou ^b   Keshavjee, Shaf H ^b   Liu, Mingyao ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BETA GALACTOSIDASE; CYCLOSPORIN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; GRAFT REJECTION; HUMORAL IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; AZATHIOPRINE; BETA-GALACTOSIDASE; CYCLOSPORINE; DRUG THERAPY, COMBINATION; GENE EXPRESSION; GENETIC VECTORS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; LAC OPERON; MALE; METHYLPREDNISOLONE; RATS; RATS, INBRED LEW; RETREATMENT; TRANSFECTION; TRANSGENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036208586     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(01)03574-3     Document Type: Article

References (22)

1. Lymphocytic airway infiltration as a precursor to fibrous obliteration ina rat model of bronchiolitis obliterans
2. Adenovirus-mediated interleukin-10 gene transfer inhibits posttransplant fibrous airway obliteration in an animal model of bronchiolitis obliterans
3. Protective effect of soluble TGF-β receptor type III gene transfection on fibrous airway obstruction in a rat model of bronchiolitis obliterans
4. Transtracheal gene transfection of donor lungs prior to organ procurement increases transgene levels at reperfusion and following transplantation
5. In vivo transtracheal adenovirus-mediated transfer of human interleukin-10 gene to donor lungs ameliorates ischemia-reperfusion injury and improves early posttransplant graft function in the rat
6. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
7. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
8. Inhibition of adenovirus-mediated gene transfer by bronchoalveolar lavage fluid
9. Repetitive adenovirus administration to the parotid gland: Role of immunological barriers and induction of oral tolerance
10. Transplant immunosuppression increases and prolongs transgene expression following adenoviral-mediated transfection of rat lungs
11. Transgene expression after adenovirus-mediated retransfection of rat lungs is increased and prolonged by transplant immunosuppression
12. Interferons impair early transgene expression by adenovirus-mediated gene transfer in muscle cells
13. Promoter attenuation in gene therapy: Interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression
14. Adenoviral-mediated gene transfer of interleukin-6 in rat lung enhances antiviral immunoglobulin A and G responses in distinct tissue compartments
15. Causes of death in lung transplant recipients
16. Gene therapy in transplantation
17. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
18. Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver
19. Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products
20. Immune responses to adenovirus and adeno-associated virus in humans
21. Longitudinal follow-up of cellular and humoral immunity induced by recombinant adenovirus-mediated gene therapy in cancer patients
22. Circumvention of vector-specific neutralizing antibody response by alternating use of human and non-human adenoviruses: Implications in gene therapy