The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver

Pharmacology

Volumn 90, Issue 5-6, 2012, Pages 233-241

  Mitchell, Sarah J ^a,b,d,e   Huizer Pajkos, Aniko ^a,b   Cogger, Victoria C ^b,c,d   McLachlan, Andrew J ^b,c   Le Couteur, David G ^b,c,d   Jones, Brett ^a,b   De Cabo, Rafael ^e   Hilmer, Sarah N ^a,b,d  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Department of Microbiology and Infectious Diseases   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Diazepam; Fenestrae; Hepatic clearance; Liver sinusoidal endothelial cell; Pseudocapillarization

Indexed keywords

ALBUMIN; DIAZEPAM; POLOXAMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG UPTAKE; ENDOTHELIUM CELL; FENESTRATION; FIRST PASS EFFECT; INDICATOR DILUTION CURVE; ISOLATED LIVER; LIVER METABOLISM; LIVER PERFUSION; LIVER SINUSOID; MALE; NONHUMAN; POROSITY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SENESCENCE; ULTRAFILTRATION;

AGING; ANIMALS; DIAZEPAM; ENDOTHELIUM; LIVER; MALE; PERFUSION; POLOXAMER; RATS; RATS, INBRED F344; SURFACE-ACTIVE AGENTS;

EID: 84866514175     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000341724     Document Type: Article

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