Instability of the cellular lipidome with age

Age

Volumn 34, Issue 4, 2012, Pages 935-947

  Hughes, Jessica R ^a   Deeley, Jane M ^a   Blanksby, Stephen J ^a   Leisch, Friedrich ^b   Ellis, Shane R ^a   Truscott, Roger J W ^c   Mitchell, Todd W ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cataract; Ceramide; Electrospray ionization mass spectrometry; Human lens; Phospholipid; Presbyopia

Indexed keywords

CERAMIDE; DIHYDOSPHINGOMYELIN; DIHYDROCERAMIDE DERIVATIVE; GLYCEROPHOSPHOLIPID; LIPIDOME; LYSOPHOSPHATIDYLETHANOLAMINE DERIVATIVE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FETUS; HUMAN; HUMAN CELL; LENS; LIPID ANALYSIS; LIPID COMPOSITION; MOLECULAR STABILITY; STRUCTURE ANALYSIS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CATARACT; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLYCEROPHOSPHOLIPIDS; HUMANS; LENS NUCLEUS, CRYSTALLINE; MALE; MEMBRANE LIPIDS; MIDDLE AGED; SAMPLING STUDIES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOMYELINS; STRUCTURE-ACTIVITY RELATIONSHIP; YOUNG ADULT;

EID: 84866508559     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9293-6     Document Type: Article

References (79)

1. Anders K, Appelkvist EL, Dallner G (1989) Age-related changes in the lipid compositions of rat and human tissues. Lipids 24(7):579-584 (Pubitemid 19184252)
2. Arnhold J, Osipov AN, Spalteholz H, Panasenko OM, Schiller J (2002) Formation of lysophospholipids from unsaturated phosphatidylcholines under the influence of hypochlorous acid. Biochimica et Biophysica Acta 1572(1):91-100 (Pubitemid 35223060)
3. Bantseev V, Herbert KL, Trevithick JR, Sivak JG (1999) Mitochondria of rat lenses: Distribution near and at the sutures. Curr Eye Res 19(6):506-516 (Pubitemid 30052878)
4. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J (2009) Evidence for cardiomyocyte renewal in humans. Science 324 (5923):98-102
5. Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Bjork-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisen J (2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A 103(33):12564-12568 (Pubitemid 44267298)
6. Borchman D, Yappert MC (1998) Age-related lipid oxidation in human lenses. Investig Ophthalmol Vis Sci 39(6):1053- 1058 (Pubitemid 28196693)
7. Borchman D, Byrdwell WC, Yappert MC (1994) Regional and age-dependent differences in the phospholipid composition of human lens membranes. Investig Ophthalmol Vis Sci 35(11):3938-3942 (Pubitemid 24334553)
8. Borchman D, Tang D, Yappert MC (1999) Lipid composition, membrane structure relationships in lens and muscle sarcoplasmic reticulum membranes. Biospectroscopy 5 (3):151-167
9. Borkenhagen LF, Kennedy EP, Fielding L (1961) Enzymatic formation and decarboxylation of phosphatidylserine. J Biol Chem 236:28-30
10. Broekhuyse R (1969) Phospholipids in tissues of eye 3. Composition and metabolism of phospholipids in human lens in relation to age and cataract formation. Biochim Biophys Acta 187(3):354
11. Cotlier E, Obara Y, Toftness B (1978) Cholesterol and phospholipids in protein fractions of human lens and senile cataract. Biochim Biophys Acta 530(2):267-278 (Pubitemid 9000148)
12. Deeley JM, Mitchell TW, Xiaojia W, Korth J, Nealon JR, Blanksby SJ, Truscott RJ (2008) Human lens lipids differ markedly from those of commonly used experimental animals. Biochim Biophys Acta 1781(6-7):288-298
13. Deeley JM, Thomas MC, Truscott RJW, Mitchell TW, Blanksby SJ (2009) Identification of abundant alkyl ether glycerophospholipids in the human lens by tandem mass spectrometry techniques. Anal Chem 81(5):1920-1930
14. Deeley JM, Hankin JA, Friedrich MG, Murphy RC, Truscott RJW, Mitchell TW, Blanksby SJ (2010) Sphingolipid distribution changes with age in the human lens. J Lipid Res 51:2753-2760
15. R Development Core Team (2009) A language and environment for statistical computing. Vienna, Austria
16. Dilmen G, Köktener A, Turhan NÖ, Tez S (2002) Growth of the fetal lens and orbit. Int J Gynecol Obstet 76(3):267- 271 (Pubitemid 34203650)
17. Dovrat A, Gershon D (1981) Rat lens superoxide dismutase and glucose-6-phosphate dehydrogenase: Studies on the catalytic activity and the fate of enzyme antigen as a function of age. Exp Eye Res 33(6):651-661 (Pubitemid 12253595)
18. Dovrat A, Scharf J, Gershon D (1984) Glyceraldehyde 3- phosphate dehydrogenase activity in rat and human lenses and the fate of enzyme molecules in the aging lens. Mech Ageing Dev 28(2-3):187-191 (Pubitemid 15175753)
19. Ellis SR, Wu C, Deeley JM, Zhu X, Truscott RJW, in het Panhuis M, Cooks RG, Mitchell TW, Blanksby SJ (2010) Imaging of human lens lipids by desorption electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 21:2095-2104
20. Estrada R, Puppato A, Borchman D, Yappert MC (2010) Reevaluation of the phospholipid composition in membranes of adult human lenses by 31P NMR and MALDI MS. Biochim Biophys Acta 1798(3):303-311
21. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
22. Friedrich MG, Truscott RJW (2009) Membrane association of proteins in the aging human lens: Profound changes take place in the fifth decade of life. Investig Ophthalmol Vis Sci 50(10):4786-4793
23. Fuchs B, Schiller J (2009) Lysophospholipids: Their generation, physiological role and detection. Are they important disease markers? Mini-Rev Med Chem 9(3):368-378
24. Glasser A, Campbell MCW (1998) Presbyopia and the optical changes in the human crystalline lens with age. Vis Res 38 (2):209-229 (Pubitemid 27503836)
25. Glasser A, Croft MA, Kaufman PL (2001) Aging of the human crystalline lens and presbyopia. Int Ophthalmol Clin 41 (2):1-15 (Pubitemid 32319526)
26. Grami V, Marrero Y, Huang L, Tang D, Yappert MC, Borchman D (2005) Alpha-crystallin binding in vitro to lipids from clear human lenses. Exp Eye Res 81(2):138-146 (Pubitemid 41080095)
27. Grether-Beck S, Bonizzi G, Schmitt-Brenden H, Felsner I, Timmer A, Sies H, Johnson JP, Piette J, Krutmann J (2000) Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. EMBO J 19(21):5793-5800
28. Han X (2002) Characterisation and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 302(2):199-212 (Pubitemid 34229724)
29. Han X, David MH, Daniel WM Jr, John K, John CM (2002) Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: Potential role in disease pathogenesis. J Neurochem 82(4):809-818
30. Harding JJ (2002) Viewing molecular mechanisms of ageing through a lens. Ageing Res Rev 1(3):465-479 (Pubitemid 38340335)
31. Hastie T, Tibshirani R (1986) Generalised additive models. Stat Sci 1(3):297-310
32. Heys KR, Cram SL, Truscott RJW (2004) Massive increase in the stiffness of the human lens nucleus with age: The basis for presbyopia? Mol Vis 10:956-963 (Pubitemid 41358196)
33. Heys KR, Friedrich MG, Truscott RJW (2008) Free and bound water in normal and cataractous human lenses. Investig Ophthalmol Vis Sci 49(5):1991-1997
34. Ho RJY, Schmetz M, Deamer DW (1987) Nonenzymatic hydrolysis of phosphatidylcholine prepared as liposomes and mixed micelles. Lipids 22:156-158
35. Hsu FF, Turk J (2007) Differentiation of 1-O-alk-1'-enyl-2-acyl and 1-O-alkyl-2-acyl glycerophospholipids by multiplestage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom 18(11):2065-2073 (Pubitemid 47633965)
36. Huang L, Grami V, Marrero Y, Tang D, Yappert MC, Rasi V, Borchman D (2005) Human lens phospholipid changes with age and cataract. Investig Ophthalmol Vis Sci 46 (5):1682-1689 (Pubitemid 44843604)
37. Ickenstein LM, Sandström MC, Mayer LD, Edwards K (2006) Effects of phospholipid hydrolysis on the aggregate structure in DPPC/DSPE-PEG2000 liposome preparations after gel to liquid crystalline phase transition. Biochim Biophys Acta 1758(2):171-180
38. Kamei A (1996) Properties of partially purified esterase in human crystalline lens and variation in its enzyme activity during aging and with advance of senile cataract. Biol Pharm Bull 19(9):1223-1226 (Pubitemid 26342269)
39. Kanfer J, Kennedy EP (1964) Metabolism and function of bacterial lipids: II. Biosynthesis of phospholipids in Escherischia coli. J Biol Chem 239:1720-1726
40. Lynnerup N, Kjeldsen H, Heegaard S, Jacobsen C, Heinemeier J (2008) Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life. PLoS ONE 3(1):e1529
41. Mecocci P, Fanó G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, Cherubini A, Vecchiet J, Senin U, Beal MF (1999) Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med 26(3-4):303-308 (Pubitemid 29013460)
42. Merchant TE, Lass JH, Meneses P, Greiner JV, Glonek T (1991) Human crystalline lens phospholipid analysis with age. Invest Ophthalmol Vis Sci 32(3):549-555
43. Messaris E, Kekis P, Memos N, Chatzigianni E, Menenakos E, Leandros E, Konstadoulakis MM (2007) Sepsis: Prognostic role of apoptosis regulators in gastrointestinal cells. World J Surg 31(4):787-794 (Pubitemid 46496213)
44. Meulle A, Salles B, Daviaud D, Valet P, Muller C (2008) Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: The example of adipogenesis. Plos One 3(10)
45. Moffat BA, LandmanKA, Truscott RJW, SweeneyMHJ, Pope JM (1999) Age-related changes in the kinetics of water transport in normal human lenses. Exp Eye Res 69(6):663-669 (Pubitemid 30046891)
46. Moss FP, Leblond CP (1970) Nature of dividing nuclei in skeletal muscle of growing rats. J Cell Biol 44(2):459- 461
47. Nealon JR, Blanksby SJ, Abbott SK, Hulbert AJ, Mitchell TW, Truscott RJW (2008a) Phospholipid composition of the rat lens is independent of diet. Exp Eye Res 87(6):502-514
48. Nealon JR, Blanksby SJ, Mitchell TW, Else PL (2008b) Systematic differences in membrane acyl composition associated with varying body mass in mammals occur in all phospholipid classes: An analysis of kidney and brain. J Exp Biol 211(Pt 19):3195-3204
49. Nealon JR, Blanksby SJ, Donaldson PJ, Truscott RJW, Mitchell TW (2011) Fatty acid uptake and incorporation into phospholipids in the rat lens. Investig Ophthalmol Vis Sci 52(2):804-809
50. Nowakowski RS (2006) Stable neuron numbers from cradle to grave. Proc Natl Acad Sci U S A 103(33):12219-12220 (Pubitemid 44267240)
51. Oborina EM, Yappert MC (2003) Effect of sphingomyelin versus dipalmitoylphosphatidylcholine on the extent of lipid oxidation. Chem Phys Lipids 123(2):223-232 (Pubitemid 36419534)
52. Ogiso M, Irie A, Kubo H, Komoto M, Matsuno T, Koide Y, Hoshi M (1993) Characterisation of neutral glycosphingolipids in human cataractous lens. J Biol Chem 268:13242- 13247 (Pubitemid 23307743)
53. Ogiso M, Okinaga T, Komoto M, Nishiyama I, Hoshi M (1994) Comparative-study of glycosphingolipid composition in mammalian lenses. Exp Eye Res 59(6):653-663
54. Ogiso M, Shogomori H, HoshiM(1998) Localization of LewisX, sialyl-LewisX and alpha-galactosyl epitopes on glycosphingolipids in lens tissues. Glycobiology 8(1):95-105 (Pubitemid 28066365)
55. Rujoi M, Jin J, Borchman D, Tang D, Yappert MC (2003) Isolation and lipid characterisation of cholesterol-enriched fractions in cortical and nuclear human lens fibers. Investig Ophthalmol Vis Sci 44(4):1634-1642 (Pubitemid 36378592)
56. Saito K, Nishijima M, Kuge O (1998) Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells. J Biol Chem 273:17199-17205 (Pubitemid 28311758)
57. Satre M, Kennedy EP (1978) Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli. J Biol Chem 253:479-483 (Pubitemid 8267675)
58. Scharf J, Dovrat A, Gershon D (1987) Defective superoxidedimutase molecules accumulate with age in human lenses. Graefe's Arch Clin Exp Ophthalmol 225(2):133-136 (Pubitemid 17052448)
59. Shapira R, Wilkinson KD, Shapira G (1988) Racemization of individual aspartate residues in human myelin basic protein. J Neurochem 50(2):649-654 (Pubitemid 18042342)
60. Shetty HU, Quentin RS, Kazushige W, Stanley IR (1996) Identification of two molecular species of rat brain phosphatidylcholine that rapidly incorporate and turn over arachidonic acid in vivo. J Neurochem 67(4):1702-1710 (Pubitemid 26314229)
61. Söderberg M, Edlund C, Kristensson K, Dallner G (1990) Lipid compositions of different regions of the human brain during aging. J Neurochem 54(2):415-423
62. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Naslund E, Britton T, Concha H, Hassan M, Ryden M, Frisen J, Arner P (2008) Dynamics of fat cell turnover in humans. Nature 453(7196):783-787 (Pubitemid 351793777)
63. Spiteller G (2006) Peroxyl radicals: Inductors of neurodegenerative and other inflammatory diseases. Their origin and how they transform cholesterol, phospholipids, plasmalogens, polyunsaturated fatty acids, sugars, and proteins into deleterious products. Free Radic Biol Med 41(3):362-387
64. Svennerholm L, Vanier MT, Jungbjer B (1978) Changes in fatty acid composition of human brain myelin lipids during maturation. J Neurochem 30(6):1383-1390 (Pubitemid 8377483)
65. Svennerholm L, Boström K, Helander CG, Jungbjer B (1991) Membrane lipids in the aging human brain. J Neurochem 56(6):2051-2059
66. Svennerholm L, Boström K, Jungbjer B, Olsson L (1994) Membrane lipids of adult human brain:lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years. J Neurochem 63(5):1802-1811 (Pubitemid 24326224)
67. Sweeney MHJ, Truscott RJW (1998) An impediment to glutathione diffusion in older normal human lenses: A possible precondition for nuclear cataract. Exp Eye Res 67 (5):587-595 (Pubitemid 29005156)
68. Tao RVP, Cotlier E (1975) Ceramides of human normal and cataractous lens. Biochim Biophys Acta 409:329-341
69. Thies F, Pillon C, Moliere P, Lagarde M, Lecerf J (1994) Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. Am J Physiol Regul Integr Comp Physiol 267(5):R1273-R1279
70. Truscott RJW (2005) Age-related nuclear cataract - oxidation is the key. Exp Eye Res 80(5):709-725 (Pubitemid 40602972)
71. Truscott RJ (2009) Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition. Exp Eye Res 88(2):241-247
72. Truscott RJW, Zhu X (2010) Presbyopia and cataract: A question of heat and time. Prog Retinal Eye Res 29 (6):487-499
73. Wood SN (2004) Stable and efficient multiple smoothing parameter estimation for generalized additive models. J Am Stat Assoc 99:673-686 (Pubitemid 39332851)
74. Yappert MC, Borchman D (2004) Sphingolipids in human lens membranes: An update on their composition and possible biological implications. Chem Phys Lipids 129(1):1-20 (Pubitemid 38293245)
75. Yappert MC, Lal S, Borchman D (1992) Age dependence and distribution of green and blue fluorophores in human lens homogenates. Investig Ophthalmol Vis Sci 33(13):3555- 3560 (Pubitemid 23001371)
76. Yappert MC, Rujoi M, Borchman D, Vorobyov I, Estrada R (2003) Glycero- versus sphingo-phospholipids: Correlations with human and non-human mammalian lens growth. Exp Eye Res 76(6):725-734 (Pubitemid 36549028)
77. Zhu X, Gaus K, Lu Y, Magenau A, Truscott RJW, Mitchell TW (2010a) Alpha- And beta-crystallins modulate the head group order of human lens membranes during aging. Investig Ophthalmol Vis Sci 51(10):5162-5167
78. Zhu X, Korlimbinis A, Truscott RJ (2010b) Age-dependent denaturation of enzymes in the human body. Rejuven Res 13(5):1-8
79. Zigman S, Paxhia T, Marinetti G, Girsch S (1984) Lipids of human lens fiber cell membranes. Curr Eye Res 3(7):887- 896 (Pubitemid 14059171)