Imaging of human lens lipids by desorption electrospray ionization mass spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 21, Issue 12, 2010, Pages 2095-2104

  Ellis, Shane R ^a   Wu, Chunping ^b   Deeley, Jane M ^a   Zhu, Xiangjia ^c   Truscott, Roger J W ^c   Panhuis, Marc in het ^a   Cooks, R Graham ^b   Mitchell, Todd W ^a   Blanksby, Stephen J ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL ETHERS; CERAMIDES; DESORPTION ELECTROSPRAY IONIZATION MASS SPECTROMETRIES; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; GLASS SLIDES; GLYCEROPHOSPHOLIPIDS; HUMAN LENS; ION TRAP MASS SPECTROMETER; LENS TISSUE; LIPID CLASS; LIPID COMPOSITION; PHOSPHATIDYLETHANOLAMINE; QUANTITATIVE ANALYSIS; SPATIAL DISTRIBUTION; STRONG ACIDS;

ACIDS; ALKYLATION; AMIDES; CHEMICAL ANALYSIS; DESORPTION; ELECTROSPRAY IONIZATION; ETHERS; HISTOLOGY; IONIZATION; LENSES; MASS SPECTROMETRY; PARTICLE DETECTORS; PHOSPHOLIPIDS; TISSUE;

OPTICAL INSTRUMENTS;

1 ALKYLPHOSPHATIDYLETHANOLAMINE; 1 ALKYLPHOSPHATIDYLSERINE; CERAMIDE; CERAMIDE 1 PHOSPHATE; LENS LIPID; LIPID; LYSO 1 ALKYL ETHER; LYSO 1 ALKYL PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN TISSUE; ION TRAP MASS SPECTROMETRY; LENS; LIPID ANALYSIS; QUANTITATIVE ANALYSIS;

ADULT; AGED; GLYCEROPHOSPHOLIPIDS; HISTOCYTOCHEMISTRY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LENS, CRYSTALLINE; MIDDLE AGED; MOLECULAR IMAGING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 78649529309     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2010.09.003     Document Type: Article

References (46)

1. Forrester J.V., Dick A.D., McMenamin P.G., Roberts F. The Eye: Basic Science in Practice 2008, 228-236. Saunders Elsevier, Philadelphia.
2. Byrdwell W.C., Borchman D., Porter R.A., Taylor K.G., Yappert M.C. Separation and Characterization of the Unknown Phospholipid in Human Lens Membranes. Invest. Ophthalmol. Vis. Sci. 1994, 35:4333-4343.
3. Deeley J.M., Mitchell T.W., Wei X., Korth J., Nealon J.R., Blanksby S.J., Truscott R.J.W. Human Lens Lipids Differ Markedly From Those of Commonly Used Experimental Animals. Biochim. Biophys. Acta, Mol. Cell. Biol. Lipids. 2008, 1781:288-298.
4. Deeley J.M., Thomas M.C., Truscott R.J.W., Mitchell T.W., Blanksby S.J. Identification of Abundant Alkyl Ether Glycerophospholipids in the Human Lens by Tandem Mass Spectrometry Techniques. Anal. Chem. 2009, 81:1920-1930.
5. Merchant T.E., Lass J.H., Meneses P., Greiner J.V., Glonek T. Human Crystalline Lens Phospholipid Analysis with Age. Invest. Ophthalmol. Vis. Sci. 1991, 32:549-555.
6. Yappert M.C., Rujoi M., Borchman D., Vorobyov I., Estrada R. Glycero- Versus Sphingophospholipids: Correlations with Human and Nonhuman Mammalian Lens Growth. Exp. Eye Res. 2003, 76:725-734.
7. Rujoi M., Estrada R., Yappert M.C. In Situ MALDI-TOF MS Regional Analysis of Neutral Phospholipids in Lens Tissue. Anal. Chem. 2004, 76:1657-1663.
8. Petkovic M., Schiller J., Müller M., Benard S., Reichl S., Arnold K., Arnhold J. Detection of Individual Phospholipids in Lipid Mixtures by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry: Phosphatidylcholine Prevents the Detection of Further Species. Anal. Biochem. 2001, 289:202-216.
9. Murphy R.C., Hankin J.A., Barkley R.M. Imaging of Lipid Species by MALDI Mass Spectrometry. J. Lipid Res. 2009, 50:S217-S322.
10. Vidova V., Pol J., Volny M., Novak P., Havlicek V., Wiedmer S.K., Holopainen J.M. Visualizing Spatial Lipid Distribution in Porcine Lens by MALDI Imaging High-Resolution Mass Spectrometry. J. Lipid Res. 2010, 51:2295-2302.
11. Deeley J.M., Hankin J.A., Friedrich M.C., Murphy R.C., Truscott R.J.W., Blanksby S.J., Mitchell T.W. Sphingolipid Distribution Changes with Age in the Human Lens. J. Lipid Res. 2010, 51:2753-2760.
12. Thibault D.B., Gillam C.J., Grey A.C., Han J., Schey K.L. MALDI Tissue Profiling of Integral Membrane Proteins from Ocular Tissues. J. Am. Soc. Mass Spectrom. 2008, 19:814-822.
13. Grey A.C., Schey K.L. Age-Related Changes in the Spatial Distribution of Human Lens α-Crystallin Products by MALDI Imaging Mass Spectrometry. Invest. Ophthalmol. Vis. Sci. 2009, 50:4319-4329.
14. Grey A.C., Schey K.L. Distribution of Bovine and Rabbit Lens α-Crystallin Products by MALDI Imaging Mass Spectrometry. Mol. Vis. 2008, 14:171-179.
15. Han J., Schey K.L. MALDI Tissue Imaging of Ocular Lens α-Crystallin. Invest. Ophthalmol. Vis. Sci. 2006, 47:2990-2996.
16. Hankin J.A., Barkley R.M., Murphy R.C. Sublimation as a Method of Matrix Application for Mass Spectrometric Imaging. J. Am. Soc. Mass Spectrom. 2007, 18:1646-1652.
17. Cooks R.G., Ouyang Z., Takats Z., Wiseman J.M. Ambient Mass Spectrometry. Science 2006, 311:1566-1570.
18. Zoltan T., M W., Bodgan G., Cooks R.G. Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization. Science 2004, 306:471-473.
19. Ifa D.R., Wiseman J.M., Song Q., Cooks R.G. Development of Capabilities for Imaging Mass Spectrometry Under Ambient Conditions with Desorption Electrospray Ionization (DESI). Int. J. Mass Spectrom. 2007, 259:8-15.
20. Dill A.L., Ifa D.R., Manicke N.E., Costa A.B., Ramos-Vara J.A., Knapp D.W., Cooks R.G. Lipid Profiles of Canine Invasive Transitional Cell Carcinoma of the Urinary Bladder and Adjacent Normal Tissue by Desorption Electrospray Ionization Imaging Mass Spectrometry. Anal. Chem. 2009, 81:8758-8764.
21. Manicke N.E., Wiseman J.M., Ifa D.R., Cooks R.G. Desorption Electrospray Ionization (DESI) Mass Spectrometry and Tandem Mass Spectrometry (MS/MS) of Phospholipids and Sphingolipids: Ionization, Adduct Formation, and Fragmentation. J. Am. Soc. Mass Spectrom. 2008, 19:531-543.
22. Wu C., Ifa D.R., Manicke N.E., Cooks R.G. Rapid, Direct Analysis of Cholesterol by Charge Labeling in Reactive Desorption Electrospray Ionization. Anal. Chem. 2009, 81:7618-7624.
23. Blanksby S.J., Mitchell T.W. Advances in Mass Spectrometry for Lipidomics. Annu. Rev. Anal. Chem. 2010, 3:433-465.
24. Wu C., Ifa D.R., Manicke N.E., Cooks R.G. Molecular Imaging of Adrenal Gland by Desorption Electrospray Ionization Mass Spectrometry. Analyst 2010, 135:28-32.
25. Wiseman J.M., Ifa D.R., Venter A., Cooks R.G. Ambient Molecular Imaging by DESI-MS. Nature Protocols 2008, 3:517-524.
26. Wiseman J.M., Ifa D.R., Zhu Y., B K.C., Manicke N.E., Kissinger P.T., Cooks R.G. Desorption Electrospray Ionization Mass Spectrometry: Imaging Drugs and Metabolites in Tissues. Proc. Nat. Acad. Sci. U.S.A. 2008, 105:18120-18125.
27. Manicke N.E., Kistler T., Ifa D.R., Cooks R.G., Ouyang Z. High-Throughput Quantitative Analysis by Desorption Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2009, 20:321-325.
28. Heys K.R., Friedrich M.G., Truscott R.J.W. Free and Bound Water in Normal and Cataractous Human Lenses. Invest. Ophthalmol. Vis. Sci. 2008, 49:1991-1997.
29. Folch J., Lees M., Stanley G.H.S. A Simple Method For The Isolation and Purification of Total Lipids from Animal Tissues. J. Biol. Chem. 1957, 226:497-509.
30. Wiseman J.M., Ifa D.R., Song Q., Cooks R.G. Tissue Imaging at Atmospheric Pressure Using Desorption Electrospray Ionization (DESI) Mass Spectrometry. Angew. Chem.; Int. Ed. 2006, 45:7188-7192.
31. Manicke N.E., Nefliu M., Wu C., Woods J.W., Reiser V., Hendrickson R.C., Cooks R.G. Imaging of Lipids in Atheroma by Desorption Electrospray Ionization Mass Spectrometry. Anal. Chem. 2009, 81:8702-8707.
32. Zigman S., Paxhia T., Marinetti G., Girsch S. Lipids of Human Lens Fiber Cell Membranes. Curr. Eye Res. 1984, 3:887-896.
33. Lapetina E.G., Soto E.F., Robertis E.D. Lipids and Proteolipids in Isolated Subcellular Membranes of Rat Brain Cortex. J. Neurochem. 1968, 15:437-445.
34. Gonen T., Cheng Y., Sliz P., Hiroaki Y., Fujiyoshi Y., Harrison S.C., Walz T. Lipidprotein interactions in double-layered two-dimensional AQP0 crystals. Nature 2005, 438:633-638.
35. Fagerholm P.P., Philipson B.T., Lindström B. Normal Human Lens-The Distribution of Protein. Exp. Eye Res. 1981, 33:615-620.
36. DePuy C.H., King R.W. Pyrolytic cis Eliminations. Chem. Rev. 1960, 60:431-457.
37. 31P NMR and MALDI MS. Biochim. Biophys. Acta, Biomembr. 2010, 1798:303-311.
38. Thomas M.C., Mitchell T.W., Harman D.G., Deeley J.M., Nealon J.R., Blanksby S.J. Ozone-Induced Dissociation: Elucidation of Double Bond Position within Mass-Selected Lipid Ions. Anal. Chem. 2007, 80:303-311.
39. Ariga T., Tao R.V., Lee B.C., Yamawaki M., Yoshino H., Scarsdale N.J., Kasama T., Kushi Y., Yu R.K. Glycolipid Composition of Human Cataractous Lenses. Characterization of Lewis-X Glycolipids. J. Biol. Chem. 1994, 269:2667-2675.
40. Ogiso M., Irie A., Kubo H., Komoto M., Matsuno T., Koide Y., Hoshi M. Characterization of Neutral Glycosphingolipids in Human Cataractous Lens. J. Biol. Chem. 1993, 268:13242-13247.
41. Gurr M.I., Harwood J.L., Fraym K.N. Lipid Biochemsitryan Introduction 2002, 275. Blackwell Science, Oxford.
42. Li L.K., So L., Spector A. Membrane Cholesterol and Phospholipid in Consecutive Concentric Sections of Human Lenses. J. Lipid Res. 1985, 26:600-609.
43. Roy D., Rosenfeld L., Spector A. Lens Plasma Membrane: Isolation and Biochemical Characterization. Exp. Eye Res. 1982, 35:113-129.
44. Heeren R.M.A., Smith D.F., Stauber J., Kükrer-Kaletas B., MacAleese L. Imaging Mass Spectrometry: Hype or Hope?. J. Am. Soc. Mass Spectrom. 2009, 20:1006-1014.
45. Rujoi M., Jin J., Borchman D., Tang D., Yappert M.C. Isolation and Lipid Characterization of Cholesterol-Enriched Fractions in Cortical and Nuclear Human Lens Fibers. Invest. Ophthalmol. Vis. Sci. 2003, 44:1634-1642.
46. Huang L., Grami V., Marrero Y., Tang D., Yappert M.C., Rasi V., Borchman D. Human Lens Phospholipid Changes with Age and Cataract. Invest. Ophthalmol. Vis. Sci. 2005, 46:1682-1689.