Massive increase in the stiffness of the human lens nucleus with age: The basis for presbyopia?

Molecular Vision

Volumn 10, Issue , 2004, Pages 956-963

  Heys, Karl Robert ^a,b   Cram, Sandra Leigh ^a   Truscott, Roger John Willis ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

WATER;

ACCOMMODATION; ADOLESCENT; ADULT; AGED; AGING; ANALYZER; ARTICLE; BIOPHYSICS; CONTROLLED STUDY; CORRELATION FUNCTION; DATA ANALYSIS; HUMAN; IN VIVO STUDY; LENS NUCLEUS; MECHANICAL PROBE; PRESBYOPIA; PRIORITY JOURNAL; RIGIDITY; THERMOGRAVIMETRY; WATER CONTENT; BIOMECHANICS; BODY WATER; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADOLESCENT; ADULT; AGED; AGING; BIOMECHANICS; BODY WATER; HUMANS; LENS NUCLEUS, CRYSTALLINE; MIDDLE AGED; PRESBYOPIA; THERMOGRAVIMETRY;

EID: 18044365894     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. von Helmholtz, H. Uber die akkomodation des auges. Albrecht von Graefe's Arch Ophth 1855:1-74.
2. Duane A. Are the current theories of accommodation correct? Am J Ophthalmol 1925; 8:196-202.
3. Fincham EF. The mechanism of accommodation. Br J Ophthalmol 1937; 8(Suppl):5-80.
4. Fincham EF, Walton J. The reciprocal actions of accommodation and convergence. J Physiol 1957; 137:488-508.
5. Eskridge JB. Review of ciliary muscle effort in presbyopia. Am J Optom Physiol Opt 1984; 61:133-8.
6. Hess C. Observations concerning accommodation organs. Klin Monatsbl Augenheilkd 1904; 42:309-15.
7. Gullstrand A. Mechanism of accommodation. In: Southall JPC, editor. Helmholtz's treatise on physiological optics. Vol 1: appendices. Rochester (NY): Optical Society of America; 1924.
8. Fisher RF. The significance of the shape of the lens and capsular energy changes in accommodation. J Physiol 1969; 201:21-47.
9. Fisher RF. The elastic constants of the human lens. J Physiol 1971; 212:147-80.
10. Koretz JF, Handelman GH. How the human eye focuses. Sci Am 1988; 259:92-9.
11. Coleman DJ. Unified model for accommodative mechanism. Am J Ophthalmol 1970; 69:1063-79.
12. Strenk SA, Strenk LM, Semmlow JL, DeMarco JK. Magnetic resonance imaging study of the effects of age and accommodation on the human lens cross-sectional area. Invest Ophthalmol Vis Sci 2004; 45:539-45.
13. Koopmans SA, Terwee T, Barkhof J, Haitjema HJ, Kooijman AC. Polymer refilling of presbyopic human lenses in vitro restores the ability to undergo accommodative changes. Invest Ophthalmol Vis Sci 2003; 44:250-7.
14. Brown NAP, Bron AJ. Lens disorders: a clinical manual of cataract diagnosis. Oxford: Butterworth-Heinemann; 1996.
15. Dubbelman M, Van der Heijde GL, Weeber HA, Vrensen GF. Changes in the internal structure of the human crystalline lens with age and accommodation. Vision Res 2003; 43:2363-75.
16. Koretz JF, Cook CA, Kaufman PL. Accommodation and presbyopia in the human eye. Changes in the anterior segment and crystalline lens with focus. Invest Ophthalmol Vis Sci 1997; 38:569-78.
17. Pau H, Kranz J. The increasing sclerosis of the human lens with age and its relevance to accommodation and presbyopia. Graefes Arch Clin Exp Ophthalmol 1991; 229:294-6.
18. Al-Ghoul KJ, Nordgren RK, Kuszak AJ, Freel CD, Costello MJ, Kuszak JR. Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis. Exp Eye Res 2001; 72:199-214.
19. Van Heyningen R. The human lens. 3. Some observations on the post-mortem lens. Exp Eye Res 1972; 13:155-60.
20. Fisher RF, Pettet BE. Presbyopia and the water content of the human crystalline lens. J Physiol 1973; 234:443-7.
21. Tabandeh H, Wilkins M, Thompson G, Nassiri D, Karim A. Hardness and ultrasonic characteristics of the human crystalline lens. J Cataract Refract Surg 2000; 26:838-41.
22. Tabandeh H, Thompson GM, Heyworth P. Lens hardness in mature cataracts. Eye 1994; 8:453-5.
23. Tabandeh H, Thompson GM, Heyworth P, Dorey S, Woods AJ, Lynch D. Water content, lens hardness and cataract appearance. Eye 1994; 8:125-9.
24. Heyworth P, Thompson GM, Tabandeh H, McGuigan S. The relationship between clinical classification of cataract and lens hardness. Eye 1993; 7:726-30.
25. Pierscionek BK. In vitro alteration of human lens curvatures by radial stretching. Exp Eye Res 1993; 57:629-35.
26. Glasser A, Campbell MC. Presbyopia and the optical changes in the human crystalline lens with age. Vision Res 1998; 38:209-29.
27. van Alphen GW, Graebel WP. Elasticity of tissues involved in accommodation. Vision Res 1991; 31:1417-38.
28. Sneddon IN. The relaxation between load and penetration in the axisymmetric boussinesq problem for a punch of arbitrary profile. International Journal of Engineering Science 1965; 3:45-57.
29. Siebinga I, Vrensen GF, De Mul FF, Greve J. Age-related changes in local water and protein content of human eye lenses measured by Raman microspectroscopy. Exp Eye Res 1991; 53:233-9.
30. Lebensohn JE. Biochemistry of the lens. Arch Ophthal 1936; 15:216-21.
31. Croft MA, Glasser A, Kaufman PL. Accommodation and presbyopia. Int Ophthalmol Clin 2001; 41:33-46.
32. Glasser A, Croft MA, Kaufman PL. Aging of the human crystalline lens and presbyopia. Int Ophthalmol Clin 2001; 41:1-15.
33. Farnsworth PN, Shyne SE. Anterior zonular shifts with age. Exp Eye Res 1979; 28:291-7.
34. Weale R. Presbyopia toward the end of the 20th century. Surv Ophthalmol 1989; 34:15-30.
35. Balazs EA, Denlinger JL. Aging changes in the vitreous. In: Sekuler R, Kline D, Dismukes K, editors. Aging and human visual function. New York: Liss; 1982. p.45-57.
36. Weeber HA, Eckert G. Stiffness distribution within the human crystalline lens and its function with age. ARVO Annual Meetng; 2004 Apr 25-29; Fort Lauderdale, FL.
37. Mathias RT, Rae JL. The lens: local transport and global transparency. Exp Eye Res 2004; 78:689-98.
38. Sweeney MH, Garland DL, Truscott RJ. Movement of cysteine in intact monkey lenses: the major site of entry is the germinative region. Exp Eye Res 2003; 77:245-51.
39. Thomson JA, Augusteyn RC. Ontogeny of human lens crystallins. Exp Eye Res 1985; 40:393-410.
40. Bours J, Wegener A, Hofmann D, Fodisch HJ, Hockwin O. Protein profiles of microsections of the fetal and adult human lens during development and ageing. Mech Ageing Dev 1990; 54:13-27.
41. Truscott RJ, Augusteyn RC. The state of sulphydryl groups in normal and cataractous human lenses. Exp Eye Res 1977; 25:139-48.
42. Sochaski MA, Jenkins AJ, Lyons TJ, Thorpe SR, Baynes JW. Isotope dilution gas chromatography/mass spectrometry method for the determination of methionine sulfoxide in protein. Anal Chem 2001; 73:4662-7.
43. Askren CC, Yu NT, Kuck JF Jr. Variation of the concentration of sulfhydryl along the visual axis of aging lenses by laser Raman optical dissection technique. Exp Eye Res 1979; 29:647-54.
44. Kuck JF, Yu NT, Askren CC. Total sulfhydryl by raman spectroscopy in the intact lens of several species: variations in the nucleus and along the optical axis during aging. Exp Eye Res 1982; 34:23-37.
45. McFall-Ngai MJ, Ding LL, Takemoto LJ, Horwitz J. Spatial and temporal mapping of the age-related changes in human lens crystallins. Exp Eye Res 1985; 41:745-58.
46. Roy D, Spector A. Absence of low-molecular-weight alpha crystallin in nuclear region of old human lenses. Proc Natl Acad Sci U S A 1976; 73:3484-7.
47. Borchman D, Byrdwell WC, Yappert MC. Regional and age-dependent differences in the phospholipid composition of human lens membranes. Invest Ophthalmol Vis Sci 1994; 35:3938-42.
48. Truscott RJ. Age-related nuclear cataract: a lens transport problem. Ophthalmic Res 2000; 32:185-94.
49. Bruckner R, Batschelet E, Hugenschmidt F. The Basel longitudinal study on aging (1955-1978). Ophthalmo-gerontological research results. Doc Ophthalmol 1986; 64:235-310.
50. Duane AJ. Normal values of the accommodation of all ages. J Am Med Assoc. 1912; 59:1010-3.
51. Donders FC. On the anomalies of accommodation and refraction of the eye; with a preliminary essay on physiological dioptrics. London: New Sydenham Society; 1864.
52. Hamasaki D, Ong J, Marg E. The amplitude of accommodation in presbyopia. Am J Optom Arch Am Acad Optom 1956; 33:3-14.
53. Pierscionek BK, Weale RA. Presbyopia - a maverick of human aging. Arch Gerontol Geriatr 1995; 20:229-40.