Antimycin A sensitizes cells to TRAIL-induced apoptosis through upregulation of DR5 and downregulation of c-FLIP and Bcl-2

International Journal of Oncology

Volumn 41, Issue 4, 2012, Pages 1425-1430

  Lee, Sung Jun ^a   Kim, Eun Ae ^a   Song, Kyoung Seob ^c   Kim, Min Jae ^a   Lee, Dae Hyung ^b   Kwon, Taeg Kyu ^d   Lee, Tae Jin ^a  

^a Yeungnam University College of Medicine   (South Korea)

^b Yeungnam University   (South Korea)

^c Kosin University   (South Korea)

^d Keimyung University   (South Korea)

Author keywords

Antimycin A; Bcl 2; c FLIP; Death receptor 5; Renal cancer; Tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

ACETYLCYSTEINE; ANTIMYCIN A1; DEATH RECEPTOR 5; FLICE INHIBITORY PROTEIN; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ARTICLE; DOWN REGULATION; DRUG ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UPREGULATION;

ANTIMYCIN A; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; KIDNEY NEOPLASMS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION;

EID: 84866500852     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1575     Document Type: Article

References (25)

1. Pan G, Ni J, Wei YF, Yu G, Gentz R and Dixit VM: An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277: 815-818, 1997.
2. Sheridan JP, Marsters SA, Pitti RM, et al: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277: 818-821, 1997.
3. Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H and Hei TK: Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res 314: 1163-1176, 2008.
4. Lee TJ, Um HJ, Min do S, Park JW, Choi KS and Kwon TK: Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med 46: 1639-1649, 2009.
5. Jung EM, Lim JH, Lee TJ, Park JW, Choi KS and Kwon TK: Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 26: 1905-1913, 2005.
6. You BR and Park WH: The effects of antimycin A on endothelial cells in cell death, reactive oxygen species and GSH levels. Toxicol In Vitro 24: 1111-1118, 2010.
7. Cai J and Jones DP: Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J Biol Chem 273: 11401-1144, 1998.
8. Pham NA, Robinson BH and Hedley DW: Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin-permeabilized cells using flow cytometry. Cytometry 41: 245-251, 2000.
9. Turrens JF: Superoxide production by the mitochondrial respiratory chain. Biosci Rep 17: 3-8, 1997.
10. Pastorino JG, Tafani M, Rothman RJ, Marcinkeviciute A, Hoek JB and Farber JL: Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J Biol Chem 274: 31734-31739, 1999.
11. Petronilli V, Penzo D, Scorrano L, Bernardi P and Di Lisa F: The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J Biol Chem 276: 12030-12034, 2001.
12. Lee TJ, Jung EM, Lee JT, et al: Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites. Mol Cancer Ther 5: 2737-2746, 2006.
13. Moon DO, Kim MO, Choi YH and Kim GY: Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-kappaB inactivation. Mol Cancer Ther 9: 1583-1595, 2010.
14. Frese-Schaper M, Schardt JA, Sakai T, Carboni GL, Schmid RA and Frese S: Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. FEBS Lett 584: 2867-2871, 2010.
15. Fan S, Li Y, Yue P, Khuri FR and Sun SY: The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. Neoplasia 12: 346-356, 2010.
16. Son YG, Kim EH, Kim JY, et al: Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin. Cancer Res 67: 8274-8284, 2007.
17. Kim YH, Jung EM, Lee TJ, et al: Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med 44: 1055-1068, 2008.
18. Jang JH, Lee TJ, Yang ES, et al: Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1. Exp Cell Res 316: 2194-2203, 2010.
19. Kauh J, Fan S, Xia M, et al: c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589. PLoS One 5: e10376, 2010.
20. Poukkula M, Kaunisto A, Hietakangas V, et al: Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail. J Biol Chem 280: 27345-27355, 2005.
21. Kaunisto A, Kochin V, Asaoka T, et al: PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ 16: 1215-1226, 2009.
22. Li W, Zhang X and Olumi AF: MG-132 sensitizes TRAILresistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res 67: 2247-2255, 2007.
23. Benayoun B, Baghdiguian S, Lajmanovich A, et al: NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB J 22: 1521-1529, 2008.
24. Nitobe J, Yamaguchi S, Okuyama M, et al: Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes. Cardiovasc Res 57: 119-128, 2003.
25. Kanayama A and Miyamoto Y: Apoptosis triggered by phagocytosis-related oxidative stress through FLIPS down-regulation and JNK activation. J Leukoc Biol 82: 1344-1352, 2007.