The effects of antimycin A on endothelial cells in cell death, reactive oxygen species and GSH levels

Toxicology in Vitro

Volumn 24, Issue 4, 2010, Pages 1111-1118

  You, Bo Ra ^a   Park, Woo Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

AMA; Apoptosis; Caspase; Endothelial cells; GSH; ROS

Indexed keywords

ACETYLCYSTEINE; ANTIMYCIN A1; BUTHIONINE SULFOXIMINE; CASPASE; CASPASE INHIBITOR; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL DEATH; CELL GROWTH; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN CONTENT; PROTEIN DEPLETION; PULMONARY ARTERY; SIGNAL TRANSDUCTION; UMBILICAL VEIN; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; ANTIMYCIN A; APOPTOSIS; BUTHIONINE SULFOXIMINE; CASPASES; CELL LINE; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GLUTATHIONE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES;

EID: 77952953823     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.03.009     Document Type: Article

References (34)

1. Alexandre A., Lehninger A.L. Bypasses of the antimycin a block of mitochondrial electron transport in relation to ubisemiquinone function. Biochim. Biophys. Acta 1984, 767:120-129.
2. Bailey H.H. L-S, R-buthionine sulfoximine: historical development and clinical issues. Chem. Biol. Interact. 1998, 111-112:239-254.
3. Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
4. Bassenge E. Endothelial function in different organs. Prog. Cardiovasc. Dis. 1996, 39:209-228.
5. Campo M.L., Kinnally K.W., Tedeschi H. The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity. J. Biol. Chem. 1992, 267:8123-8127.
6. Chen H.M., Yan X.J. Antioxidant activities of agaro-oligosaccharides with different degrees of polymerization in cell-based system. Biochim. Biophys. Acta 2005, 1722:103-111.
7. Costantini P., Chernyak B.V., Petronilli V., Bernardi P. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J. Biol. Chem. 1996, 271:6746-6751.
8. Estrela J.M., Ortega A., Obrador E. Glutathione in cancer biology and therapy. Crit. Rev. Clin. Lab. Sci. 2006, 43:143-181.
9. Han Y.H., Kim S.Z., Kim S.H., Park W.H. Arsenic trioxide inhibits growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. Am. J. Physiol. Renal Physiol. 2007, 293:F511-F520.
10. Han Y.H., Kim S.H., Kim S.Z., Park W.H. Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Oncol. Rep. 2008, 20:689-693.
11. Han Y.H., Kim S.H., Kim S.Z., Park W.H. Caspase inhibitor decreases apoptosis in pyrogallol-treated lung cancer Calu-6 cells via the prevention of GSH depletion. Int. J. Oncol. 2008, 33:1099-1105.
12. Han Y.H., Kim S.Z., Kim S.H., Park W.H. Apoptosis in pyrogallol-treated Calu-6 cells is correlated with the changes of intracellular GSH levels rather than ROS levels. Lung Cancer 2008, 59:301-314.
13. Han Y.H., Park W.H. Growth inhibition in antimycin A treated-lung cancer Calu-6 cells via inducing a G1 phase arrest and apoptosis. Lung cancer 2009, 65:150-160.
14. Han Y.H., Park W.H. Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. Oncol. Rep. 2009, 21:253-261.
15. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J. Cell. Mol. Med. 2004, 8:455-464.
16. Irani K. Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ. Res. 2000, 87:179-183.
17. King M.A. Antimycin A-induced killing of HL-60 cells: apoptosis initiated from within mitochondria does not necessarily proceed via caspase 9. Cytometry A 2005, 63:69-76.
18. King M.A., Radicchi-Mastroianni M.A. Antimycin A-induced apoptosis of HL-60 cells. Cytometry 2002, 49:106-112.
19. Lum H., Roebuck K.A. Oxidant stress and endothelial cell dysfunction. Am. J. Physiol. Cell Physiol. 2001, 280:C719-C741.
20. Maguire J.J., Kagan V.E., Packer L. Electron transport between cytochrome c and alpha tocopherol. Biochem. Biophys. Res. Commun. 1992, 188:190-197.
21. Nakayama K., Okamoto F., Harada Y. Antimycin A: isolation from a new Streptomyces and activity against rice plant blast fungi. J. Antibiot. (Tokyo) 1956, 9:63-66.
22. Oberley L.W., Oberley T.D. Role of antioxidant enzymes in cell immortalization and transformation. Mol. Cell. Biochem. 1988, 84:147-153.
23. Panduri V., Weitzman S.A., Chandel N.S., Kamp D.W. Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 286:L1220-L1227.
24. Park W.H., Han Y.W., Kim S.H., Kim S.Z. An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis. J. Cell. Biochem. 2007, 102:98-109.
25. Park W.H., Han Y.W., Kim S.W., Kim S.H., Cho K.W., Kim S.Z. Antimycin A induces apoptosis in As4.1 juxtaglomerular cells. Cancer Lett. 2007, 251:68-77.
26. Park W.H., Seol J.G., Kim E.S., Hyun J.M., Jung C.W., Lee C.C., Kim B.K., Lee Y.Y. Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 2000, 60:3065-3071.
27. Pastorino J.G., Tafani M., Rothman R.J., Marcinkeviciute A., Hoek J.B., Farber J.L. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J. Biol. Chem. 1999, 274:31734-31739.
28. Petronilli V., Penzo D., Scorrano L., Bernardi P., Di Lisa F. The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J. Biol. Chem. 2001, 276:12030-12034.
29. Pham N.A., Robinson B.H., Hedley D.W. Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin-permeabilized cells using flow cytometry. Cytometry 2000, 41:245-251.
30. Simon H.U., Haj-Yehia A., Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000, 5:415-418.
31. Wallach-Dayan S.B., Izbicki G., Cohen P.Y., Gerstl-Golan R., Fine A., Breuer R. Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006, 290:L790-L796.
32. Wilcox C.S. Reactive oxygen species: roles in blood pressure and kidney function. Curr. Hypertens. Rep. 2002, 4:160-166.
33. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997, 275:1129-1132.
34. Zelko I.N., Mariani T.J., Folz R.J. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic. Biol. Med. 2002, 33:337-349.