Pigment epithelium-derived factor gene loaded in cRGD-PEG-PEI suppresses colorectal cancer growth by targeting endothelial cells

International Journal of Pharmaceutics

Volumn 438, Issue 1-2, 2012, Pages 1-10

  Li, Lei ^a   Yang, Jun ^a   Wang, Wei Wei ^b   Yao, Ya Chao ^a   Fang, Shu Huan ^a   Dai, Zhi Yu ^a   Hong, Hong Hai ^a   Yang, Xia ^a,b   Shuai, Xin Tao ^b   Gao, Guo Quan ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

cRGD; Gene therapy; HUVECs; PEDF; PEG PEI

Indexed keywords

MACROGOL; PIGMENT EPITHELIUM DERIVED FACTOR; POLYETHERIMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER GROWTH; COLORECTAL CANCER; CONTROLLED STUDY; DRUG TARGETING; ENDOTHELIUM CELL; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA; EYE PROTEINS; GENE TRANSFER TECHNIQUES; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, NUDE; NANOPARTICLES; NERVE GROWTH FACTORS; OLIGOPEPTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; SERPINS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84866497082     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.043     Document Type: Article

References (44)

1. R. Abe, T. Shimizu, S. Yamagishi, A. Shibaki, S. Amano, Y. Inagaki, H. Watanabe, H. Sugawara, H. Nakamura, M. Takeuchi, T. Imaizumi, and H. Shimizu Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo Am. J. Pathol. 164 2004 1225 1232
2. P.C. Brooks, R.A. Clark, and D.A. Cheresh Requirement of vascular integrin alpha v beta 3 for angiogenesis Science 264 1994 569 571
3. M.V. Bais, M.A. Nugnet, D.N. Stephens, S.S. Sume, K.H. Kirsch, G.E. Sonenshein, and P.C. Trackman Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts PLoS ONE 7 2012 e31188
4. D. Cunningham, W. Atkin, H.J. Lenz, H.T. Lynch, B. Minsky, B. Nordlinger, and N. Starling Colorectal cancer Lancet 375 2010 1030 1047
5. F.Y. Cui, X.R. Song, Z.Y. Li, S.Z. Li, B. Mu, Y.Q. Mao, Y.Q. Wei, and L. Yang The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for therapy of colon carcinoma Oncol. Rep. 24 2010 661 668
6. X.A. Chen, L.J. Zhang, Z.J. He, W.W. Wang, B. Xu, Q. Zhong, X.T. Shuai, L.Q. Yang, and Y.B. Deng Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells Int. J. Nanomed. 6 2011 843 853
7. C.R. Dass, K.G. Contreras, D.E. Dunstan, and P.F. Choong Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma Biomaterials 28 2007 3026 3033
8. D.W. Dawson, O.V. Volpert, P. Gillis, S.E. Crawford, H. Xu, W. Benedict, and N.P. Bouck Pigment epithelium-derived factor: a potent inhibitor of angiogenesis Science 285 1999 245 248
9. E.J. Duh, H.S. Yang, I. Suzuma, M. Miyagi, E. Youngmanm, K. Mori, M. Katai, L. Yan, K. Suzuma, K. West, S. Davarya, T. Patrick, P. Gehlbach, J. Pearlman, J.W. Crabb, L.P. Aiello, P.A. Campochiaro, and D.J. Zack Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth Invest. Ophthalmol. Vis. Sci. 43 2002 821 829
10. E.T. Ek, C.R. Dass, and P.F. Choong PEDF: a potential molecular therapeutic target with multiple anti-cancer activities Trends Mol. Med. 12 2006 497 502
11. E.T. Ek, C.R. Dass, and P.F. Choong Pigment epithelium-derived factor: a multimodal tumor inhibitor Mol. Cancer Ther. 5 2006 1641 1646
12. E.T. Ek, C.R. Dass, K.G. Contreras, and P.F. Choong Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth angiogenesis and metastasis Cancer Gene Ther. 14 2007 616 626
13. R. Esipov, K. Beyrakhova, V. Likhvantseva, E. Stepanova, V. Stepanenko, M. Kostromina, Y. Abramchik, and A. Miroshnikov Antiangiogenic and antivascular effects of a recombinant tumstatin-derived peptide in a corneal neovascularization model Biochimie 94 2012 1368 1375
14. Y. Gao, A. Yao, W. Zhang, S. Lu, Y. Yu, L. Deng, A. Yin, Y. Xia, B. Sun, and X. Wang Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice Oncogene 29 2010 2784 2794
15. Y. Gao, W. Zhang, L. Zhao, and X.H. Wang Pigment epithelium-derived factor gene therapy inhibits the growth of transplanted human hepatocellular carcinoma in nude mice Zhonghua Gan Zang Bing Za Zhi 17 2009 363 367
16. M. Guan, C.P. Pang, H.F. Yam, K.F. Cheung, W.W. Liu, and Y. Lu Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor Cancer Gene Ther. 11 2004 325 332
17. M. Guan, H. Jiang, C. Xu, R. Xu, Z. Chen, and Y. Lu Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2 Cancer Biol. Ther. 6 2007 419 425
18. S. Halin, S.H. Rudolfsson, J.A. Doll, S.E. Crawford, P. Wikstrom, and A. Bergh Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment Neoplasia 12 2010 336 345
19. R. Hase, M. Miyamoto, H. Uehara, M. Kadoya, Y. Ebihara, Y. Murakami, R. Takahashi, S. Mega, L. Li, T. Shichinohe, Y. Kawarada, and S. Kondo Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice Clin. Cancer Res. 11 2005 8737 8744
20. S.S. He, H.S. Shi, T. Yin, Y.X. Li, S.T. Luo, Q.J. Wu, L. Lu, Y.Q. Wei, and L. Yang AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits lewis lung carcinoma growth in mice Oncol. Rep. 27 2012 1142 1148
21. T. Kawaguchi, S.I. Yamagishi, and M. Sata Structure-function relationships of PEDF Curr. Mol. Med. 10 2010 302 311
22. R.J. Kok, A.J. Schraa, E.J. Bos, H.E. Moorlag, S.A. Asgeirsdottir, M. Everts, D.K. Meijer, and G. Molema Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics Bioconjug. Chem. 13 2002 128 135
23. A. Konson, S. Pradeep, and R. Seger Phosphomimetic mutants of pigment epithelium-derived factor with enhanced antiangiogenic activity as potent anticancer agents Cancer Res. 70 2010 6247 6257
24. A. Konson, S. Pradeep, and R. Seger Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest J. Biol. Chem. 286 2011 3540 3551
25. S. Lehrman Virus treatment questioned after gene therapy death Nature 401 1999 517 518
26. Q. Liu, and D.A. Muruve Molecular basis of the inflammatory response to adenovirus vectors Gene Ther. 10 2003 935 940
27. U. Lungwitz, M. Breunig, T. Blunk, and A. Gopferich Polyethylenimine- based non-viral gene delivery systems Eur. J. Pharm. Biopharm. 60 2005 247 266
28. M. Lee, and S.W. Kim Polyethylene glycol-conjugated copolymers for plasmid DNA delivery Pharm. Res. 22 2005 1 10
29. S. Maubant, D. Saint-Dizier, M. Boutillon, F. Perron-Sierra, P.J. Casara, J.A. Hickman, G.C. Tucker, and E. Van Obberghen-Schilling Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells Blood 108 2006 3035 3044
30. T. Niidome, and L. Huang Gene therapy progress and prospects: non-viral vectors Gene Ther. 9 2002 1647 1652
31. D.I. Obrand, and P.H. Gordon Incidence and patterns of recurrence following curative resection for colorectal carcinoma Dis. Colon Rectum 40 1997 15 24
32. M. Oba, S. Fukushima, N. Kanayama, K. Aoyagi, N. Nishiyama, H. Koyama, and K. Kataoka Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins Bioconjug. Chem. 18 2007 1415 1423
33. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Global cancer statistics 2002 CA Cancer J. Clin. 55 2005 74 108
34. S. Prabha, W.Z. Zhou, J. Panyam, and V. Labhasetwar Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles Int. J. Pharm. 244 2002 105 115
35. J.Y. Sun, V. Anand-Jawa, S. Chatterjee, and K.K. Wong Immune responses to adeno-associated virus and its recombinant vectors Gene Ther. 10 2003 964 976
36. M. Sakae, T. Ito, C. Yoshihara, N. Iida-Tanaka, H. Yanagie, M. Eriguchi, and Y. Koyama Highly efficient in vivo gene transfection by plasmid/PEI complexes coated by anionic PEG derivatives bearing carboxyl groups and RGD peptide Biomed. Pharmacother. 62 2008 448 453
37. H. Tan, Y. Li, L. Chen, T. Kudoh, T. Kasai, and M. Seno The conformational polymorphism of the green fluorescent protein Mol. Biol. (Mosk) 46 2012 156 161
38. L. Wang, V. Schmitz, A. Perez-Mediavilla, I. Izal, J. Prieto, and C. Qian Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor Mol. Ther. 8 2003 72 79
39. N. Weidner, J.P. Semple, W.R. Welch, and J. Folkman Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma N. Engl. J. Med. 324 1991 1 8
40. Q.J. Wu, C.Y. Gong, S.T. Luo, D.M. Zhang, S. Zhang, H.S. Shi, L. Lu, H.X. Yan, S.S. He, D.D. Li, L. Yang, X. Zhao, and Y.Q. Wei AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model BMC Cancer 12 2012 129
41. L.P. Yang, P. Cheng, X.C. Peng, H.S. Shi, W.H. He, F.Y. Cui, S.T. Luo, Y.Q. Wei, and L. Yang Anti-tumor effect of adenovirus-mediated gene transfer of pigment epithelium-derived factor on mouse B16-F10 melanoma J. Exp. Clin. Cancer Res. 28 2009 75
42. J. Yang, S. Chen, X. Huang, J. Han, Q. Wang, D. Shi, R. Cheng, G. Gao, and X. Yang Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis Cancer Biol. Ther. 9 2010 967 974
43. H. Yang, R. Cheng, G. Liu, Q. Zhong, C. Li, W. Cai, Z. Yang, J. Ma, X. Yang, and G. Gao PEDF inhibits growth of retinoblastoma by anti-angiogenic activity Cancer Sci. 100 2009 2419 2425
44. Y. Zhang, J. Han, X. Yang, C. Shao, Z. Xu, R. Cheng, W. Cai, J. Ma, Z. Yang, and G. Gao Pigment epithelium-derived factor inhibits angiogenesis and growth of gastric carcinoma by down-regulation of VEGF Oncol. Rep. 26 2011 681 686