Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

Age

Volumn 34, Issue 4, 2012, Pages 845-861

  Diderich, Karin E M ^a   Nicolaije, Claudia ^a   Priemel, Matthias ^b   Waarsing, Jan H ^a   Day, Judd S ^a   Brandt, Renata M C ^a   Schilling, Arndt F ^b,c   Botter, Sander M ^a   Weinans, Harrie ^a   Van Der Horst, Gijsbertus T J ^a   Hoeijmakers, Jan H J ^a   Van Leeuwen, Johannes P T M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Aging; Bone fragility; Bone marrow stem cells; Bone strength; DNA repair syndromes; Mouse models

Indexed keywords

PARATHYROID HORMONE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE AGE; BONE DEVELOPMENT; BONE FRAGILITY; BONE MARROW CELL; BONE MASS; BONE METABOLISM; BONE STRENGTH; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOID; OSTEOLYSIS; PHENOTYPE; PREMATURE AGING; TRABECULAR BONE; TRICHOTHIODYSTROPHY;

AGE FACTORS; AGING, PREMATURE; ANALYSIS OF VARIANCE; ANIMALS; BONE AND BONES; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR-DEFICIENCY DISORDERS; FEMALE; HEMATOPOIETIC STEM CELLS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOPOROSIS; PARATHYROID HORMONE; RANDOM ALLOCATION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TRICHOTHIODYSTROPHY SYNDROMES;

EID: 84866494797     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9291-8     Document Type: Article

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