Searching for ways to switch on brown fat: Are we getting warmer?

Journal of Molecular Endocrinology

Volumn 49, Issue 2, 2012, Pages

  Whittle, Andrew ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPHEDRINE; GLUCOSE; INSULIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SIBUTRAMINE; TRIACYLGLYCEROL;

ADIPOCYTE; BROWN ADIPOSE TISSUE; COMORBIDITY; DIABETES MELLITUS; DISEASE ASSOCIATION; ENERGY EXPENDITURE; EPIDEMIC; GENE EXPRESSION; HEART OUTPUT; HEART OUTPUT MEASUREMENT; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPID METABOLISM; LIPID STORAGE; MACROPHAGE; METABOLIC DISORDER; MITOCHONDRIAL RESPIRATION; NONHUMAN; OBESITY; OXYGEN SUPPLY; PRIORITY JOURNAL; REVIEW; STRESS; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, BROWN; ANIMALS; HUMANS; LIVER; MACROPHAGES; MICE; MUSCLE, SKELETAL; MYOCARDIUM; OBESITY; THERMOGENESIS;

EID: 84866423884     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0080     Document Type: Review

References (63)

1. Aflaki E, Radovic B, Chandak PG, Kolb D, Eisenberg T, Ring J, Fertschai I, Uellen A, Wolinski H, Kohlwein SD et al. 2011 Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. Journal of Biological Chemistry 286 7418-7428. (doi:10.1074/jbc.M110.175703)
2. Allender S, Scarborough P, O'Flaherty M & Capewell S 2008 Patterns of coronary heart disease mortality over the 20th century in England and Wales: possible plateaus in the rate of decline. BMC Public Health 8 148. (doi:10.1186/1471-2458-8-148)
3. Apovian CM, Bigornia S, Mott M, Meyers MR, Ulloor J, Gagua M, McDonnell M, Hess D, Joseph L & Gokce N 2008 Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arteriosclerosis, Thrombosis, and Vascular Biology 28 1654-1659. (doi:10.1161/ATVBAHA.108.170316)
4. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C et al. 2011 Brown adipose tissue activity controls triglyceride clearance. Nature Medicine 17 200-205. (doi:10.1038/nm.2297)
5. Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessi-Fulgheri P, Zhang C, Takahashi N, Sarzani R & Collins S 2012 Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. Journal of Clinical Investigation 122 1022-1036. (doi:10.1172/JCI59701)
6. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ et al. 2012 A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481 463-468. (doi:10.1038/nature10777)
7. Cannon B & Nedergaard J 2004 Brown adipose tissue: function and physiological significance. Physiological Reviews 84 277-359. (doi:10.1152/physrev.00015.2003)
8. Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Boren J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA et al. 2011 Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. European Heart Journal 32 1345-1361. (doi:10.1093/eurheartj/ehr112)
9. Collins S, Yehuda-Shnaidman E & Wang H 2010 Positive and negative control of Ucp1 gene transcription and the role of b-adrenergic signaling networks. International Journal of Obesity 34 (Suppl 1) S28-S33. (doi:10.1038/ijo.2010.180)
10. Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE & Kharitonenkov A 2008 Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149 6018-6027. (doi:10. 1210/en.2008-0816)
11. Cypess AM & Kahn CR 2010 Brown fat as a therapy for obesity and diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity 17 143-149. (doi:10.1097/MED.0b013e328337a81f)
12. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A et al. 2009 Identification and importance of brown adipose tissue in adult humans. New England Journal of Medicine 360 1509-1517. (doi:10.1056/NEJMoa0810780)
13. Cypess AM, Chen YC, Sze C, Wang K, English J, Chan O, Holman AR, Tal I, Palmer MR, Kolodny GM et al. 2012 Cold but not sympathomimetics activates human brown adipose tissue in vivo. PNAS 109 10001-10005. (doi:10.1073/pnas.1207911109)
14. Finer N, Bloom SR, Frost GS, Banks LM & Griffiths J 2000 Sibutramine is effective for weight loss and diabetic control in obesity with type 2 diabetes: a randomised, double-blind, placebo-controlled study. Diabetes, Obesity & Metabolism 2 105-112. (doi:10.1046/j.1463-1326. 2000.00071.x)
15. Flierl MA, Rittirsch D, Nadeau BA, Sarma JV, Day DE, Lentsch AB, Huber-Lang MS & Ward PA 2009 Upregulation of phagocytederived catecholamines augments the acute inflammatory response. PLoS ONE 4 e4414. (doi:10.1371/journal.pone.0004414)
16. Guerra C, Koza RA, Yamashita H, Walsh K & Kozak LP 1998 Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. Journal of Clinical Investigation 102 412-420. (doi:10.1172/JCI3155)
17. Haller CA & Benowitz NL 2000 Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. New England Journal of Medicine 343 1833-1838. (doi:10.1056/NEJM200012213432502)
18. Hansson GK 2005 Inflammation, atherosclerosis, and coronary artery disease. New England Journal of Medicine 352 1685-1695. (doi:10.1056/NEJMra043430)
19. Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R & Villarroya F 2010 Hepatic FGF21 expression is induced at birth via PPARa in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metabolism 11 206-212. (doi:10.1016/j.cmet.2010.02.001)
20. Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T & Villarroya F 2011 Thermogenic activation induces FGF21 expression and release in brown adipose tissue. Journal of Biological Chemistry 286 12983-12990. (doi:10.1074/jbc.M110.215889)
21. Johnson F, Mavroggiani A, Ucci M, Vidal-Puig A & Wardle J 2011 Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obesity Reviews 12 543-551. (doi:10.1111/j.1467-789X.2010.00851.x)
22. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA et al. 2005 FGF-21 as a novel metabolic regulator. Journal of Clinical Investigation 115 1627-1635. (doi:10.1172/JCI23606)
23. Lafontan M, Moro C, Berlan M, Crampes F, Sengenes C & Galitzky J 2008 Control of lipolysis by natriuretic peptides and cyclic GMP. Trends in Endocrinology and Metabolism 19 130-137. (doi:10.1016/j. tem.2007.11.006)
24. Lean ME, James WP, Jennings G & Trayhurn P 1986 Brown adipose tissue in patients with phaeochromocytoma. International Journal of Obesity 10 219-227.
25. Lee P, Ho KK & Greenfield JR 2011 Hot fat in a cool man: infrared thermography and brown adipose tissue. Diabetes, Obesity and Metabolism 13 92-93. (doi:10.1111/j.1463-1326.2010.01318.x)
26. Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R et al. 2009 Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circulation Research 105 1072-1082. (doi:10.1161/CIRCRESAHA.109.199570)
27. Lopez M, Varela L, Vazquez MJ, Rodriguez-Cuenca S, Gonzalez CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R et al. 2010 Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine 16 1001-1008. (doi:10.1038/nm.2207)
28. Lumeng CN, Bodzin JL & Saltiel AR 2007 Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Journal of Clinical Investigation 117 175-184. (doi:10.1172/JCI29881)
29. McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN et al. 2011 Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes 60 47-55. (doi:10.2337/db10-0867)
30. Meyer CW, Willershauser M, Jastroch M, Rourke BC, Fromme T, Oelkrug R, Heldmaier G & Klingenspor M 2010 Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 299 R1396-R1406. (doi:10.1152/ajpregu. 00021.2009)
31. Mirbolooki MR, Constantinescu CC, Pan ML & Mukherjee J 2012 Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and b3-adrenergic receptor activation. EJNMMI Research 1 30. (doi:10.1186/2191-219X-1-30)
32. Misono KS 2011 Natriuretic peptides and their receptors. FEBS Journal 278 1791. (doi:10.1111/j.1742-4658.2011.08114.x)
33. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM & Chawla A 2011 Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480 104-108. (doi:10.1038/nature10653)
34. O'Flaherty M, Ford E, Allender S, Scarborough P & Capewell S 2008 Coronary heart disease trends in England and Wales from 1984 to 2004: concealed levelling of mortality rates among young adults. Heart 94 178-181. (doi:10.1136/hrt.2007.118323)
35. Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M & Kuro-o M 2007 BetaKlotho is required for metabolic activity of fibroblast growth factor 21. PNAS 104 7432-7437. (doi:10.1073/pnas.0701600104)
36. Ouellet V, Routhier-Labadie A, Bellemare W, Lakhal-Chaieb L, Turcotte E, Carpentier AC & Richard D 2011 Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. Journal of Clinical Endocrinology and Metabolism 96 192-199. (doi:10.1210/jc.2010-0989)
37. Ouellet V, Labbe SM, Blondin DP, Phoenix S, Guerin B, Haman F, Turcotte EE, Richard D & Carpentier AC 2012 Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. Journal of Clinical Investigation 122 545-552. (doi:10.1172/JCI60433)
38. Pedersen BK & Febbraio MA 2012 Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology 8 457-465. (doi:10.1038/nrendo.2012.49)
39. Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B & Nedergaard J 2010 Chronic peroxisome proliferator-activated receptor g (PPARg) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. Journal of Biological Chemistry 285 7153-7164. (doi:10.1074/jbc.M109.053942)
40. Pfannenberg C, Werner MK, Ripkens S, Stef I, Deckert A, Schmadl M, Reimold M, Haring HU, Claussen CD & Stefan N 2010 Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes 59 1789-1793. (doi:10.2337/db10-0004)
41. Prieur X, Mok CY, Velagapudi VR, Nunez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S et al. 2011 Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 60 797-809. (doi:10.2337/db10-0705)
42. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H et al. 2008 PRDM16 controls a brown fat/skeletal muscle switch. Nature 454 961-967. (doi:10.1038/nature07182)
43. Seebacher F & Glanville EJ 2010 Low levels of physical activity increase metabolic responsiveness to cold in a rat (Rattus fuscipes). PLoS ONE 5 e13022. (doi:10.1371/journal.pone.0013022)
44. Silva JE 1995 Thyroid hormone control of thermogenesis and energy balance. Thyroid 5 481-492. (doi:10.1089/thy.1995.5.481)
45. Skarulis MC, Celi FS, Mueller E, Zemskova M, Malek R, Hugendubler L, Cochran C, Solomon J, Chen C & Gorden P 2009 Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. Journal of Clinical Endocrinology and Metabolism 95 256-262. (doi:10.1210/jc. 2009-0543)
46. Sun Z 2010 Cardiovascular responses to cold exposure. Frontiers in Bioscience: a Journal and Virtual Library 2 495-503. (doi:10.2741/e108)
47. Thorp EB 2010 Mechanisms of failed apoptotic cell clearance by phagocyte subsets in cardiovascular disease. Apoptosis 15 1124-1136. (doi:10.1007/s10495-010-0516-6)
48. Torp-Pedersen C, Caterson I, Coutinho W, Finer N, Van Gaal L, Maggioni A, Sharma A, Brisco W, Deaton R, Shepherd G et al. 2007 Cardiovascular responses to weight management and sibutramine in high-risk subjects: an analysis from the SCOUT trial. European Heart Journal 28 2915-2923. (doi:10.1093/eurheartj/ehm217)
49. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y et al. 2008 New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454 1000-1004. (doi:10.1038/nature07221)
50. Unger RH, Clark GO, Scherer PE & Orci L 2009 Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochimica et Biophysica Acta 1801 209-214. (doi:10.1016/j.bbalip.2009.10.006)
51. Vaartjes I, O'Flaherty M, Grobbee DE, Bots ML & Capewell S 2011 Coronary heart disease mortality trends in the Netherlands 1972-2007. Heart 97 569-573. (doi:10.1136/hrt.2010.206565)
52. Virtue S & Vidal-Puig A 2008 It's not how fat you are, it's what you do with it that counts. PLoS Biology 6 e237. (doi:10.1371/journal.pbio. 0060237)
53. Virtue S & Vidal-Puig A 2010 Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Biochimica et Biophysica Acta 1801 338-349. (doi:10.1016/j.bbalip.2009.12.006)
54. West DB, Boozer CN, Moody DL & Atkinson RL 1992 Dietary obesity in nine inbred mouse strains. American Journal of Physiology 262 R1025-R1032.
55. Whittle AJ & Vidal-Puig A 2012 NPs-heart hormones that regulate brown fat? Journal of Clinical Investigation 122 804-807. (doi:10.1172/JCI62595)
56. Whittle AJ, Lopez M & Vidal-Puig A 2011 Using brown adipose tissue to treat obesity-the central issue. Trends in Molecular Medicine 17 405-411. (doi:10.1016/j.molmed.2011.04.001)
57. Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vazquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S et al. 2012 BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149 871-885. (doi:10.1016/j. cell.2012.02.066)
58. Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G et al. 2012 Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150 366-376. (doi:10.1016/j.cell.2012.05.016)
59. Wymann MP & Schneiter R 2008 Lipid signalling in disease. Nature Reviews Molecular Cell Biology 9 162-176. (doi:10.1038/nrm2335)
60. Xu X, Ying Z, Cai M, Xu Z, Li Y, Jiang SY, Tzan K, Wang A, Parthasarathy S, He G et al. 2011 Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 300 R1115-R1125. (doi:10.1152/ajpregu. 00806.2010)
61. Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y & SaitoM2011 Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity 19 13-16. (doi:10.1038/oby.2010.105)
62. Yoneshiro T, Aita S, Kawai Y, Iwanaga T & Saito M 2012 Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. American Journal of Clinical Nutrition 95 845-850. (doi:10.3945/ajcn.111. 018606)
63. Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J & Cinti S 2009 The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB Journal 23 3113-3120. (doi:10.1096/fj.09-133546)