Brain-derived neurotrophic factor and exercise in fibromyalgia syndrome patients: A mini review

Rheumatology International

Volumn 32, Issue 9, 2012, Pages 2593-2599

  Nugraha, Boya ^a,b   Karst, Matthias ^a   Engeli, Stefan ^a   Gutenbrunner, Christoph ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF INDONESIA   (Indonesia)

Author keywords

BDNF; Exercise; Fibromyalgia; Pain

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ALLODYNIA; DEPRESSION; EXERCISE; FATIGUE; FIBROMYALGIA; HEADACHE; HUMAN; HYPERALGESIA; IRRITABLE COLON; MOOD DISORDER; MORNING STIFFNESS; NERVE CELL PLASTICITY; NONHUMAN; PAIN THRESHOLD; PHYSIOTHERAPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PSYCHOTHERAPY; REVIEW; SLEEP DISORDER;

BRAIN-DERIVED NEUROTROPHIC FACTOR; EXERCISE; FIBROMYALGIA; HUMANS; MOOD DISORDERS; NEURONAL PLASTICITY; PAIN;

EID: 84866423545     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-011-2348-2     Document Type: Review

References (78)

1. Carville SF, Arendt-Nielsen S, Bliddal H, Blotman F, Branco JC, Buskila D, Da Silva JA, Danneskiold-Samsøe B, Dincer F, Henriksson C, Henriksson KG, Kosek E, Longley K, McCarthy GM, Perrot S, Puszczewicz M, Sarzi-Puttini P, Silman A, Späth M, Choy EH, EULAR (2008) EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Diss 67:536-541 (Pubitemid 351498437)
2. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, McCain GA, Reynolds WJ, Romano TJ, Russel IJ, Sheon RP (1990) The American College of Rheumatology Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33:160-172 (Pubitemid 20098653)
3. Wolfe F (2003) Pain extent and diagnosis: development and validation of the regional pain scale in 12,799 patients with rheumatic disease. J Rheumatol 30:369-378 (Pubitemid 36152607)
4. Eich W, Häuser W, Friedel E, Klement A, Herrmann M, Petzke F, Offenbächer M, Schiltenwolf M, Sommer C, Tölle T, Henningsen P (2008) Definition, classification and diagnosis of fibromyalgia syndrome. Schmerz 22(3):255-266
5. Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, Katz RS, Mease P, Russel AS, Russel IJ, Winfield JB, Yunus MB (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 62(5):600-610
6. Crofford LJ, Mease PJ, Simpson SL, Young JP Jr, Martin SA, Haig GM, Sharma U (2008) Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin. Pain 136:419-431
7. Sommer C, Häuser W, Gerhold K, Joraschky P, Petzke F, Tölle T, Ü çeyler N, Winkelmann A, Thieme K (2008) Etiology and pathophysiology of fibromyalgia syndrome and chronic widespread pain. Der Schmerz 22(3):267-282
8. Jacobi G, Reinhard Dettmeyer R, Sibylle Banaschak S, Burkhard Brosig B, Herrmann B (2010) Child abuse and neglect: diagnosis and management. Dtsch Arztebl Int 107(13):231-240
9. May A (2008) Chronic pain may change the structure of the brain. Pain 137:7-15
10. Tracey I, Bushnell MC (2009) How Neuroimaging Studies have challenged us to rethink: is chronic pain a disease? J Pain 10(11):1113-1120
11. Hucho T, Levine JD (2007) Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron 55(3):365-376 (Pubitemid 47126268)
12. Häuser W, Thieme K, Turk DC (2010) Guidelines on the management of fibromyalgia syndrome-A systematic review Review Article. Eur J Pain 14(1):5-10
13. Bennet DL (2001) Neurotrophic factors: important regulators of nociceptive function. Neuroscientist 7:13-17
14. Thompson SW, Bennett L, Kerr BJ, Bradbury E, McMahon SB (1999) Brain derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord. PNAS 96(14):s7714-s7718
15. Merighi A, Salio C, Ghirri A, Lossi L, Ferrini F, Betelli C, BardonR (2008) BDNF as a pain modulator. Prog Neurobiol 85:297-313
16. Kaplan DR, Miller FD (2000) Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10:381-391 (Pubitemid 30389307)
17. Zhou XF, Deng YS, Xian CJ, Zhong JH (2000) Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats. Eur J Neurosci 12:100-105 (Pubitemid 30068415)
18. Kerr BJ, Bradbury EJ, Bennett DL, Trivedi PM, Dassan P, French J, Shelton DB, McMahon SB, Thompson SW (1999) Brainderived neurotrophic factor modulates nociceptive sensory inputs and NMDA evoked responses in the rat spinal cord. J Neurosci 19:5138-5148 (Pubitemid 29270149)
19. Pezet S, Malcangio M, Lever IJ, Perkinton MS, Thompson SW, Williams RJ, McMahon SB (2002) Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn. Mol Cell Neurosci 21:684-695 (Pubitemid 36062724)
20. Fukuoka T, Kondo E, Dai Y, Hashimoto N, Noguchi K (2001) Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. J Neurosci 21(13):4891-4900 (Pubitemid 32565647)
21. Yajima Y, Narita M, Usui A, Kaneko C, Miyatake M (2005) Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice. J Neurochem 93:584
22. Siuciak JA, Altar CA, Wiegand SJ, Lindsay RM (1994) Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3. Brain Res 633(1-2):326-330 (Pubitemid 24021278)
23. Duric V, McCarson KE (2007) Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain. Mol Pain 3:32
24. Xu HW, Li XC, Li HD, Ruan HZ, Liu ZZ (2000) Effects of corticotrophin on pain behaviour and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain. Acta Pharmacol Sin 21(7):600-604
25. Liebl DJ, Huang W, Young W, Parada LF (2001) Regulation of Trk receptors following contusion of the rat spinal cord. Exp Neurol 167(1):15-26 (Pubitemid 32066405)
26. Malcangio M, Lessmann V (2003) A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors. Trends Pharmacol Sci 24:116-121 (Pubitemid 36293776)
27. Lever I, Cunningham J, Grist J, Yip PK, Malcangio M (2003) Release of BDNF and GABA in the dorsal horn of neuropathic rats. Eur J Neurosci 18(5):1169-1174 (Pubitemid 37115036)
28. Lindholm D, Heumann R, Meyer M, Thoenen H (1987) Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330:658-659 (Pubitemid 18005581)
29. Meyer M, Matsuoka I, Wetmore C, Olson L, Thoenen H (1992) Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol 119:45-54
30. Hammarberg H, Piehl F, Cullheim S, Fjell J, Hokfelt T, Fried K (1996) GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury. Neuroreport 7:857-860 (Pubitemid 26167964)
31. Amino S, Itakura M, Ohnishi H, Tsujimura J, Koizumi S, Takei N, Takahashi M (2002) Nerve growth factor enhances neurotransmitter release from PC 12 cells by increasing Ca2?-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J Biochem 131:887-894 (Pubitemid 34717594)
32. Sarchielli P, Di Filippo M, Nardi K, Calabresi P (2007) Sensitization, glutamate, and the link between migraine and fibromyalgia. Curr Pain Headache Rep 11:343-351 (Pubitemid 47505865)
33. Lindsay RM, Wiegand SJ, Altar CA, Di Stefano PS (1994) Neurotrophic factors: from molecule to man. Trends Neurosci 17:182-190 (Pubitemid 24128459)
34. Lewin GR, Barde YA (1996) Physiology of the neurotrophins. Ann Rev Neurosci 19:289-317 (Pubitemid 26080831)
35. Escobar ML, Figueroa-Guzman Y, Gomez-Palacio-Schjetnan A (2003) In vivo insular cortex LTP induced by brain-derived neurotrophic factor. Brain Res 991:274-279 (Pubitemid 37297961)
36. Staud R (2006) Are tender point injections beneficial: the role of tonic nociception in fibromyalgia. Curr Pharm 12:23-27
37. Ren K, Dubner R (2007) Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors. Mol Neurobiol 35:224-235 (Pubitemid 350129684)
38. Frank L, Wiegand SJ, Siuciak JA, Lindsay RM, Rudge JS (1997) Effects of BDNF infusion on regulation of TrkB protein and message in adult rat brain. Exp Neurol 145:62-70 (Pubitemid 27244280)
39. Guo W, Robbins MT, Wie F, Zou S, Dubner R, Ren K (2006) Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending facilitation. J Neurosci 26:126-137 (Pubitemid 43089525)
40. Miki K, Fukuoka T, Tokunaga A, Kondo E, Dai Y, Noguchi K (2000) Diffferential effect of brain derived neurotrophic factor on high-threshol mechanosensitivity in a rat neuropathic pain model. Neurosci Lett 278:85-88 (Pubitemid 30009903)
41. Groth R, Aanonsen L (2002) Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or TrkB, prevent inflammation-induced hyperalgesia. Pain 100:171-181 (Pubitemid 35305134)
42. Neeper SA, Góauctemez-Pinilla F, Choi J, Cotman C (1995) Exercise, neurotrophins. Nature 373:109
43. Shen H, Tong L, Balazs R, Cotman CW (2001) Physical activity elicits sustain activation of the cyclic AMP response elementbinding protein and mitogen-activated protein kinase in the rat hippocampus. Neuroscience 107:219-229 (Pubitemid 33145344)
44. Carro E, Nunez A, Busiguina S, Torres-Aleman I (2000) Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci 20:2926-2933 (Pubitemid 30220318)
45. Griesbach GS, Hovda DA, Molteni R, Wu A, Gomez-Pinilla F (2004) Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor up-regulation and recovery of function. Neuroscience 125:129-139 (Pubitemid 38402166)
46. Namiki J, Kojima A, Tator CH (2000) Effect of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats. J Neurotrauma 12:1219-1231
47. Trejo JL, Carro E, Torres Aleman I (2001) Circulating insulin-like growth factor I mediates exercise induced increases in thenumber of new neurons in the adult hippocampus. J Neurosci 21:1628-1634 (Pubitemid 32182203)
48. Soya H, Nakamura T, Deocaris CC, Kimpara A, Miho Iimura M, Fujikawa T, Hyukki Chang H, McEwen BS, Takeshi Nishijima T (2007) BDNF induction with mild exercise in the rat hippocampus. Biochem Biophys Res Comm 358(4):961-967 (Pubitemid 46828982)
49. Griesbach GS, Hovda DA, Gomez-Pinilla F (2009) Exerciseinduced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res 1288:105-115
50. Liu YF, Chen HI, Yu L, Kuo YM, Wu FS, Chuang JI, Liao PC, Jen CJ (2008) Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiol Learn Memory 90(1):81-89
51. Kim MW, Bang MS, Han TR, Ko YJ, Yoon BW, Kim JH, Kang LM, Lee KM, Kim MH (2005) Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic ratbrain. Brain Res 1052(1):16-21
52. Widenfalk J, Olson L, Thoren P (1999) Deprived of habitual running rats downregulate BDNF and TrkB messages in the brain. Neurosci Res 34(3):125-132
53. Marais L, Dan J, Stein DJ, Daniels WMU (2009) Exercise increases BDNF levels in the striatum and decreases depressivelike behavior in chronically stressed rats. Metab Brain Dis 24:587-597
54. Ferris LT, Williams JS, Shen C-L (2007) The effect of acute exercise on serum brain-derived neurotrophic. Factor levels and cognitive function. Med Sci Sports Exerc 39:728-734 (Pubitemid 46555802)
55. Rojas VS, Abel T, Lindschulten R, Hollmann W, Bloch W, Strüder HK (2008) Impact of exercise on neuroplasticity-related proteins in spinal cord injured humans. Neuroscience 153(4):1064-1070
56. Bircan C, Karasel SA, Akgün B, Alper S (2008) Effects of muscle strengthening versus aerobic exercise program in fibromyalgia. Rheumatol Int 28:527-532
57. Valim V, Oliveira L, Suda A, Silva L, de Assis M, Barros Neto T, Feldman D, Natour J (2003) Aerobic fitness effects in fibromyalgia. J Rheumatol 30:1060-1069 (Pubitemid 36529632)
58. Mannerkopi K, Nordeman L, Ericsson A, Arndorw M, GAU Study Group (2009) Pool exercise for patients with fibromyalgia or chronic widespread pain: a randomized controlled trial and subgroup analyses. J Rehabil Med 41:751-760
59. Gowans SE, deHueck A, Voss S, Silaj A, Abbey SE, Reynolds WJ (2001) Effect of a randomized controlled trial of exercise on mood and physical function in individuals with fibromyalgia. Arthritis Rheum 45:519-529 (Pubitemid 33140587)
60. van Koulil S, van Lankveld W, Kraaimaat FW, van Helmond T, Vedder A, van Hoorn H, Donders R, de Jong AJ, Haverman JF, Korff KJ, van Riel PL, Cats HA, Evers AW (2010) Tailored cognitive-behavioral therapy and exercise training for high-risk patients with fibromyalgia. Arthritis Care Res (Hoboken) 62(10):1377-1385
61. Sanudo B, Galiano D, Carrasco L, de Hoyo M, McVeigh JG (2011) Effects of a prolonged exercise program on key health outcomes in women with fibromyalgia: a randomized controlled trial. J Rehabil Med 43(6):521-526
62. Haas L, Portela LVC, Böhmer AE, Oses JP, Lara DR (2010) Increased plasma levels of brain derived neurotrophic factor (BDNF) in patients with fibromyalgia. Neurochem Res 35(5):830-834
63. Laske C, Stransky E, Eschweiler GW (2007) Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants. J Psychiatr Res 41:600-605 (Pubitemid 46330393)
64. Tsai SJ (2005) Possible involvement of brain-derived neurotrophic factor in the antinociceptive effect of antidepressants in neuropathic pain. Med Hypotheses 65:530-533
65. Xu H, Steven Richardson J, Li XM (2003) Dose-related effects of chronic antidepressants on neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampus. Neuropsychopharmacology 28:53-62
66. De Foubert G, Carney SL, Robinson CS, Destexhe EJ, Tomlinson R, Hicks CA, Murray TK, Gaillard JP, Deville C, Xhenseval V, Thomas CE, O'Neill MJ, Zetterström TS (2004) Fluoxetineinduced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 128:597-604 (Pubitemid 39277429)
67. Dias BG, Banerjee SB, Duman RS, Vaidya VA (2003) Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 45:553-563 (Pubitemid 36936988)
68. Russo-Neustadt AA, Beard RC, Huang YM, Cotman CW (2000) Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience 101:305-312
69. Ivy AS, Rodriguez FG, Garcia C, Chen MJ, Russo-Neustadt AA (2003) Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacol Biochem Behav 75:81-88 (Pubitemid 36577583)
70. Coppell AL, Pei Q, Zetterstrom TS (2003) Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology 44:903-910 (Pubitemid 36515026)
71. Altar CA, Whitehead RE, Chen R, Wortwein G, Madsen TM (2003) Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry 54:703-709 (Pubitemid 37281386)
72. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001) Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50:260-265 (Pubitemid 32778442)
73. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato N, Watanabe H, Shinoda N, Okada SI, Iyo M (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54:70-75 (Pubitemid 36776725)
74. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E et al (2003) Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci 23:349-357 (Pubitemid 36050437)
75. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109:143-148 (Pubitemid 34258493)
76. Lemtiri-Chlieh F, Levine ES (2010) BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex. J Neurophysiol 104(4):1923-1932
77. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D (2010) Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci 13(10):1265-1270
78. Kaufmann I, Schelling G, Eisner C, Richter HP, Krauseneck T, Vogeser M, Hauer D, Campolongo P, Chouker A, Beyer A, Thiel M (2008) Anandamide and neutrophil function in patients with fibromyalgia. Psychoneuroendocrinology 33(5):676-685