Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca2+-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase

Journal of Biochemistry

Volumn 131, Issue 6, 2002, Pages 887-894

  Amino, Shinya ^a   Itakura, Makoto ^b   Ohnishi, Hiroshi ^b   Tsujimura, Jun ^c   Koizumi, Shinichi ^d   Takei, Nobuyuki ^e   Takahashi, Masami ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d NOVARTIS PHARMA K K   (Japan)

^e NIIGATA UNIVERSITY   (Japan)

Author keywords

MAP kinase; Neurotransmitter release; NGF; PI 3 kinase; TrkA

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CALCIUM; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE KINASE A; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCHOLINE; CALCIUM ION; DOPAMINE; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTRANSMITTER; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; WORTMANNIN;

ANIMAL; ARTICLE; CELL STRAIN; ENZYME ACTIVATION; METABOLISM; RAT; SECRETORY VESICLE; ACETYLCHOLINE RELEASE; ANIMAL CELL; CONTROLLED STUDY; DEPOLARIZATION; DOPAMINE RELEASE; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; MEMBRANE PERMEABILITY; NERVE CELL DIFFERENTIATION; NEUROTRANSMITTER RELEASE; NONHUMAN; SYNAPTIC TRANSMISSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CALCIUM; ENZYME ACTIVATION; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NEUROTRANSMITTER AGENTS; PC12 CELLS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; RATS; RECEPTOR, TRKA; SECRETORY VESICLES;

ANIMALIA;

EID: 0036594256     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003179     Document Type: Article

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