Fibrin accumulation plays a critical role in the sensitization to lipopolyccharide-induced liver injury caused by ethanol in mice

Hepatology

Volumn 49, Issue 5, 2009, Pages 1545-1553

  Beier, Juliane I ^a   Luyendyk, James P ^b   Guo, Luping ^a   von Montfort, Claudia ^a   Staunton, Donald E ^c   Arteel, Gavin E ^a,d  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c Cis Thera Inc   (United States)

^d UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALANINE AMINOTRANSFERASE; ALCOHOL; ANTIBODY; ASPARTATE AMINOTRANSFERASE; FIBRIN; HIRUDIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN ANTITHROMBIN COMPLEX; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR RECEPTOR 1; ANTITHROMBIN III; ANTITHROMBIN III PROTEASE COMPLEX; ANTITHROMBIN III-PROTEASE COMPLEX; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE HYDROLASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER CIRRHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATTENUATION; BLOOD CLOTTING; CELL DEATH; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; EXTRACELLULAR SPACE; FIBRIN DEPOSITION; FIBRINOLYSIS; HEPATITIS; HISTOPATHOLOGY; LIPID STORAGE; LIVER INJURY; LIVER STRUCTURE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSITIZATION; ALCOHOL LIVER DISEASE; ANIMAL; BLOOD; C57BL MOUSE; DRINKING BEHAVIOR; DRUG EFFECT; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIVER; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ALCOHOL DRINKING; ANIMALS; ANTITHROMBIN III; ENZYME ACTIVATION; ETHANOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRIN; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE HYDROLASES; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; TRIGLYCERIDES;

EID: 66149091909     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22847     Document Type: Article

References (31)

1. Grant BF, Dufour MC, Harford TC. Epidemiology of alcoholic liver disease. Semin Liver Dis 1988;8:12-25.
2. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. HEPATOLOGY 1989;9:349-351.
3. Frost RA, Nystrom G, Burrows PV, Lang CH. Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions. Alcohol Clin Exp Res 2005;29:1247-1256.
4. Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I, et al. Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. Gastroenterology 2006;130:2099-2112.
5. Kitching AR, Kong YZ, Huang XR, Davenport P, Edgtton KL, Carmeliet P, et al. Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol 2003;14:1487-1495.
6. Luyendyk JP, Maddox JF, Green CD, Ganey PE, Roth RA. Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. HEPATOLOGY 2004;40:1342-1351.
7. von Montfort C, Beier JI, Guo L, Kaiser JP, Arteel GE. Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice. Am J Physiol Gastrointest Liver Physiol 2008;294:G1227-G1234.
8. Beier JI, Guo L, von Montfort C, Kaiser JP, Joshi-Barve S, Arteel GE. New role of resistin in lipopolysaccharide-induced liver damage in mice. J Pharmacol Exp Ther 2008;325:801-808.
9. Guo L, Richardson KS, Tucker LM, Doll MA, Hein DW, Arteel GE. Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats. HEPATOLOGY 2004;40:583-589.
10. Luyendyk JP, Shaw PJ, Green CD, Maddox JF, Ganey PE, Roth RA. Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J Pharmacol Exp Ther 2005;314:1023-1031.
11. Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, et al. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood 2004;103:1342-1347.
12. Hamaguchi E, Takamura T, Shimizu A, Nagai Y. Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells. J Pharmacol Exp Ther 2003;307:987-994.
13. Koteish A, Yang S, Lin H, Huang X, Diehl AM. Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. J Biol Chem 2002;277:13037-13044.
14. Bode CH, Kugler V, Bode JCH. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 1987;4:8-14.
15. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Brenner DA, et al. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 1998;115:443-451.
16. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, et al. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol 1998;13(Suppl):S39-S50.
17. Hewett JA, Roth RA. The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria. J Pharmacol Exp Ther 1995;272:53-62.
18. Pearson JM, Schultze AE, Schwartz KA, Scott MA, Davis JM, Roth RA. The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat. J Pharmacol Exp Ther 1996;278:378-383.
19. Luyendyk JP, Copple BL, Barton CC, Ganey PE, Roth RA. Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: Involvement of endothelium and the coagulation system. Toxicol Sci 2003;72:171-181.
20. Hewett JA, Roth RA. The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria. J Pharmacol Exp Ther 1995;272:53-62.
21. Ganey PE, Luyendyk JP, Maddox JF, Roth RA. Adverse hepatic drug reactions: Inflammatory episodes as consequence and contributor. Chem Biol Interact 2004;150:35-51.
22. Bergheim I, Luyendyk JP, Steele C, Russell GK, Guo L, Roth RA, et al. Metformin prevents endotoxin-induced liver injury after partial hepatectomy. J Pharmacol Exp Ther 2005;316:1053-1061.
23. Holdsworth SR, Thomson NM, Glasgow EF, Atkins RC. The effect of defibrination on macrophage participation in rabbit nephrotoxic nephritis: Studies using glomerular culture and electron microscopy. Clin Exp Immunol 1979;37:38-43.
24. Loike JD, el Khoury J, Cao L, Richards CP, Rascoff H, Mandeville JT, et al. Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenyl-alanine. J Exp Med 1995;181:1763-1772.
25. Sato Y, Tsuboi R, Lyons R, Moses H, Rifkin DB. Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: A self-regulating system. J Cell Biol 1990;111:757-763.
26. Espevik T, Figari IS, Shalaby MR, Lackides GA, Lewis GD, Shepard HM, et al. Inhibition of cytokine production by cyclosporin A and transforming growth factor beta. J Exp Med 1987;166:571-576.
27. Skurk T, Hauner H. Obesity and impaired fibrinolysis: Role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord 2004;28:1357-1364.
28. Tsikouris JP, Suarez JA, Meyerrose GE. Plasminogen activator inhibitor-1: Physiologic role, regulation, and the influence of common pharmacologic agents. J Clin Pharmacol 2002;42:1187-1199.
29. Sawdey MS, Loskutoff DJ. Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. J Clin Invest 1991;88:1346-1353.
30. Montes R, Rodriguez-Wilhelmi P, Hurtado V, Matsukawa A, Montes M, Hermida J, et al. The endotoxin-induced plasminogen activator inhibitor-1 increase in rabbits is not tumor necrosis factor-alpha dependent and can occur in the absence of interleukin-1beta. Thromb Haemost 2002;88: 639-643.
31. Chen J, Ishac EJ, Dent P, Kunos G, Gao B. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. Biochem J 1998;334:669-676.