Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy

Neuropharmacology

Volumn 64, Issue , 2013, Pages 45-52

  Harms, Jonathan E ^a   Benveniste, Morris ^b   MacLean, John K F ^c   Partin, Kathryn M ^a   Jamieson, Craig ^d  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Benzamide; CX614; Cyclothiazide; Deactivation; Desensitization; Electrophysiology; JAMI1001A; Kinetics; LY404187

Indexed keywords

2 [2 [4 (HYDROXYMETHYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1YL]ACETAMIDO] 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXAMIDE; AMINO ACID RECEPTOR AFFECTING AGENT; AMPA RECEPTOR; AMPA RECEPTOR MODULATOR; JAMI 1001A; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NERVE CELL PLASTICITY; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; STRUCTURE BASED DRUG DESIGN; X RAY CRYSTALLOGRAPHY;

ACETAMIDES; ALLOSTERIC SITE; BENZAMIDES; CHEMISTRY, PHARMACEUTICAL; DATABASES, PROTEIN; DRUG DESIGN; EXCITATORY AMINO ACID AGONISTS; HEK293 CELLS; HUMANS; KIDNEY; KINETICS; LIGANDS; NOOTROPIC AGENTS; PROTEIN CONFORMATION; PROTEIN SUBUNITS; PYRAZOLES; RECEPTORS, AMPA; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOPHENES;

EID: 84866382191     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.06.008     Document Type: Article

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