Structure based evolution of a novel series of positive modulators of the AMPA receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 805-811

  Jamieson, Craig ^a,b   MacLean, John K F ^a,b   Brown, Christopher I ^a   Campbell, Robert A ^a   Gillen, Kevin J ^a   Gillespie, Jonathan ^a   Kazemier, Bert ^a   Kiczun, Michael ^a   Lamont, Yvonne ^a   Lyons, Amanda J ^a   Moir, Elizabeth M ^a   Morrow, John A ^a   Pantling, John ^a   Rankovic, Zoran ^a   Smith, Lynn ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Allosteric modulator; AMPA receptor; Indane; SBDD; Scaffold hopping

Indexed keywords

AMPA RECEPTOR AGONIST;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; MOLECULAR EVOLUTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; INDANS; MICROSOMES, LIVER; MODELS, MOLECULAR; NERVOUS SYSTEM DISEASES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 78651238809     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.098     Document Type: Article

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