Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles heel

Oncogene

Volumn 31, Issue 37, 2012, Pages 4095-4106

  Sidler, D ^a   Brockmann, A ^b   Mueller, J ^a   Nachbur, U ^c   Corazza, N ^a   Renzulli, P ^d   Hemphill, A ^a   Brunner, T ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d Kantonsspital Muensterlingen   (Switzerland)

Author keywords

apoptosis; colon cancer; Bim; chemotherapy; glutathione S transferase; TRAIL

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIBIOTIC AGENT; BIM PROTEIN; CISPLATIN; DOXORUBICIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; IRINOTECAN; RM 4819; STRESS ACTIVATED PROTEIN KINASE; THIAZOLIDE DERIVATIVE; UNCLASSIFIED DRUG; UO 126;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELLULAR STRESS RESPONSE; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZAMIDES; CACO-2 CELLS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DOWN-REGULATION; GLUTATHIONE S-TRANSFERASE PI; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; THIAZOLES; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84866373730     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.575     Document Type: Article

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