메뉴 건너뛰기




Volumn 24, Issue 2, 2010, Pages 423-441

Novel therapies for myelodysplastic syndromes

Author keywords

Clofarabine; Ezatiostat; Farnesyltransferase inhibitors; Histone deacetylase inhibitors; Laromustine; Myelodysplastic syndromes

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; 4 PHENYLBUTYRIC ACID; 5 AZA 2' DEOXYCYTIDINE; ALEMTUZUMAB; AZACITIDINE; BELINOSTAT; CLADRIBINE; CLOFARABINE; CLORETAZINE; CYTARABINE; ENTINOSTAT; EZATIOSTAT; FLUDARABINE; FR 901229; GAMMA GLUTAMYL S BENZYLCYSTEINYLPHENYLGLYCINE DIETHYL ESTER; GLUTATHIONE DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; LENALIDOMIDE; LONAFARNIB; MELPHALAN; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; PANOBINOSTAT; ROMIDEPSIN; SNDX 275; THYMOCYTE ANTIBODY; TIPIFARNIB; TLK 199; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 77950533453     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2010.02.010     Document Type: Review
Times cited : (19)

References (64)
  • 1
    • 30144443817 scopus 로고    scopus 로고
    • The myelodysplastic syndromes: diagnosis and treatment
    • Steensma D.P., Bennett J.M. The myelodysplastic syndromes: diagnosis and treatment. Mayo Clin Proc 2006, 81:104.
    • (2006) Mayo Clin Proc , vol.81 , pp. 104
    • Steensma, D.P.1    Bennett, J.M.2
  • 2
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux P., Mufti G.J., Hellstrom-Lindberg E., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10:223.
    • (2009) Lancet Oncol , vol.10 , pp. 223
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 3
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    • Kantarjian H., Issa J.P., Rosenfeld C.S., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006, 106:1794.
    • (2006) Cancer , vol.106 , pp. 1794
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 4
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List A., Dewald G., Bennett J., et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006, 355:1456.
    • (2006) N Engl J Med , vol.355 , pp. 1456
    • List, A.1    Dewald, G.2    Bennett, J.3
  • 5
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
    • Silverman L.R., Demakos E.P., Peterson B.L., et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002, 20:2429.
    • (2002) J Clin Oncol , vol.20 , pp. 2429
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 6
    • 55049098618 scopus 로고    scopus 로고
    • Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches
    • Gore S.D., Hermes-DeSantis E.R. Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches. Cancer Control 2008, 15(Suppl):40.
    • (2008) Cancer Control , vol.15 , Issue.SUPPL. , pp. 40
    • Gore, S.D.1    Hermes-DeSantis, E.R.2
  • 7
    • 37549022694 scopus 로고    scopus 로고
    • DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Griffiths E.A., Gore S.D. DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol 2008, 45:23.
    • (2008) Semin Hematol , vol.45 , pp. 23
    • Griffiths, E.A.1    Gore, S.D.2
  • 9
    • 40549130642 scopus 로고    scopus 로고
    • Cracking the enigmatic linker histone code
    • Godde J.S., Ura K. Cracking the enigmatic linker histone code. J Biochem 2008, 143:287.
    • (2008) J Biochem , vol.143 , pp. 287
    • Godde, J.S.1    Ura, K.2
  • 10
    • 67249116835 scopus 로고    scopus 로고
    • Targeting histone deacetylases for the treatment of disease
    • Lawless M.W., Norris S., O'Byrne K.J., et al. Targeting histone deacetylases for the treatment of disease. J Cell Mol Med 2009, 13:826.
    • (2009) J Cell Mol Med , vol.13 , pp. 826
    • Lawless, M.W.1    Norris, S.2    O'Byrne, K.J.3
  • 11
    • 34249033131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application
    • Santini V., Gozzini A., Ferrari G. Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 2007, 8:383.
    • (2007) Curr Drug Metab , vol.8 , pp. 383
    • Santini, V.1    Gozzini, A.2    Ferrari, G.3
  • 12
    • 49349107518 scopus 로고    scopus 로고
    • Lysine acetylation: codified crosstalk with other posttranslational modifications
    • Yang X.J., Seto E. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 2008, 31:449.
    • (2008) Mol Cell , vol.31 , pp. 449
    • Yang, X.J.1    Seto, E.2
  • 13
    • 33845627416 scopus 로고    scopus 로고
    • Acetylation and histone deacetylase inhibitors in cancer
    • Kortenhorst M.S., Carducci M.A., Shabbeer S. Acetylation and histone deacetylase inhibitors in cancer. Cell Oncol 2006, 28:191.
    • (2006) Cell Oncol , vol.28 , pp. 191
    • Kortenhorst, M.S.1    Carducci, M.A.2    Shabbeer, S.3
  • 14
    • 47249100271 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents
    • Moradei O., Vaisburg A., Martell R.E. Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents. Curr Top Med Chem 2008, 8:841.
    • (2008) Curr Top Med Chem , vol.8 , pp. 841
    • Moradei, O.1    Vaisburg, A.2    Martell, R.E.3
  • 15
    • 69449093587 scopus 로고    scopus 로고
    • HDAC inhibitor-based therapies and haematological malignancy
    • Stimson L., Wood V., Khan O., et al. HDAC inhibitor-based therapies and haematological malignancy. Ann Oncol 2009, 20:1293.
    • (2009) Ann Oncol , vol.20 , pp. 1293
    • Stimson, L.1    Wood, V.2    Khan, O.3
  • 16
    • 70350720044 scopus 로고    scopus 로고
    • MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
    • Figueroa M.E., Skrabanek L., Li Y., et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood 2009, 114(16):3448-3458.
    • (2009) Blood , vol.114 , Issue.16 , pp. 3448-3458
    • Figueroa, M.E.1    Skrabanek, L.2    Li, Y.3
  • 17
    • 46949098033 scopus 로고    scopus 로고
    • Current status of epigenetic treatment in myelodysplastic syndromes
    • Kuendgen A., Lubbert M. Current status of epigenetic treatment in myelodysplastic syndromes. Ann Hematol 2008, 87:601.
    • (2008) Ann Hematol , vol.87 , pp. 601
    • Kuendgen, A.1    Lubbert, M.2
  • 18
    • 67651153048 scopus 로고    scopus 로고
    • New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
    • Cang S., Ma Y., Liu D. New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer. J Hematol Oncol 2009, 2:22.
    • (2009) J Hematol Oncol , vol.2 , pp. 22
    • Cang, S.1    Ma, Y.2    Liu, D.3
  • 19
    • 33947581039 scopus 로고    scopus 로고
    • Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias
    • Gojo I., Jiemjit A., Trepel J.B., et al. Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias. Blood 2007, 109:2781.
    • (2007) Blood , vol.109 , pp. 2781
    • Gojo, I.1    Jiemjit, A.2    Trepel, J.B.3
  • 20
    • 34848819070 scopus 로고    scopus 로고
    • Combined methyltransferase/histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMoL and AML: clinical response, histone acetylation and DNA damage
    • Gore S.D., Jiemjit A., Silverman L.B., et al. Combined methyltransferase/histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMoL and AML: clinical response, histone acetylation and DNA damage. ASH Annual Meeting Abstracts 2006, 108:517.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 517
    • Gore, S.D.1    Jiemjit, A.2    Silverman, L.B.3
  • 21
    • 49349104503 scopus 로고    scopus 로고
    • A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia
    • Gimsing P., Hansen M., Knudsen L.M., et al. A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia. Eur J Haematol 2008, 81:170.
    • (2008) Eur J Haematol , vol.81 , pp. 170
    • Gimsing, P.1    Hansen, M.2    Knudsen, L.M.3
  • 22
    • 38949144400 scopus 로고    scopus 로고
    • Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes
    • Klimek V.M., Fircanis S., Maslak P., et al. Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes. Clin Cancer Res 2008, 14:826.
    • (2008) Clin Cancer Res , vol.14 , pp. 826
    • Klimek, V.M.1    Fircanis, S.2    Maslak, P.3
  • 23
    • 67449109154 scopus 로고    scopus 로고
    • Phase IA/II study of oral panobinostat (lbh589), a novel pan- deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies
    • Ottmann O.G., Spencer A., Prince H.M., et al. Phase IA/II study of oral panobinostat (lbh589), a novel pan- deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies. ASH Annual Meeting Abstracts 2008, 112:958.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 958
    • Ottmann, O.G.1    Spencer, A.2    Prince, H.M.3
  • 24
    • 34347376811 scopus 로고    scopus 로고
    • Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukemia
    • Kalff A., Shortt J., Farr J., et al. Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukemia. ASH Annual Meeting Abstracts 2006, 108:4554.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 4554
    • Kalff, A.1    Shortt, J.2    Farr, J.3
  • 25
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Gottlicher M., Minucci S., Zhu P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001, 20:6969.
    • (2001) EMBO J , vol.20 , pp. 6969
    • Gottlicher, M.1    Minucci, S.2    Zhu, P.3
  • 26
    • 66749108988 scopus 로고    scopus 로고
    • Randomized phase ii study of combined epigenetic therapy: decitabine vs. decitabine and valproic acid in MDS and AML
    • Issa J.P., Castoro R., Ravandi-Kashani F., et al. Randomized phase ii study of combined epigenetic therapy: decitabine vs. decitabine and valproic acid in MDS and AML. ASH Annual Meeting Abstracts 2008, 112:228.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 228
    • Issa, J.P.1    Castoro, R.2    Ravandi-Kashani, F.3
  • 27
    • 35748962020 scopus 로고    scopus 로고
    • Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes
    • Siitonen T., Timonen T., Juvonen E., et al. Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes. Haematologica 2007, 92:1119.
    • (2007) Haematologica , vol.92 , pp. 1119
    • Siitonen, T.1    Timonen, T.2    Juvonen, E.3
  • 28
    • 29144481615 scopus 로고    scopus 로고
    • Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia
    • Kuendgen A., Knipp S., Fox F., et al. Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia. Ann Hematol 2005, 84(Suppl 13):61.
    • (2005) Ann Hematol , vol.84 , Issue.13 SUPPL. , pp. 61
    • Kuendgen, A.1    Knipp, S.2    Fox, F.3
  • 29
    • 29144484694 scopus 로고    scopus 로고
    • Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia
    • Bug G., Ritter M., Wassmann B., et al. Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia. Cancer 2005, 104:2717.
    • (2005) Cancer , vol.104 , pp. 2717
    • Bug, G.1    Ritter, M.2    Wassmann, B.3
  • 30
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G., Kantarjian H.M., Sanchez-Gonzalez B., et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood 2006, 108:3271.
    • (2006) Blood , vol.108 , pp. 3271
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 31
    • 68049120458 scopus 로고    scopus 로고
    • Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes
    • Voso M.T., Santini V., Finelli C., et al. Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. Clin Cancer Res 2009, 15:5002.
    • (2009) Clin Cancer Res , vol.15 , pp. 5002
    • Voso, M.T.1    Santini, V.2    Finelli, C.3
  • 32
    • 0036554808 scopus 로고    scopus 로고
    • Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia
    • Gore S.D., Weng L.J., Figg W.D., et al. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clin Cancer Res 2002, 8:963.
    • (2002) Clin Cancer Res , vol.8 , pp. 963
    • Gore, S.D.1    Weng, L.J.2    Figg, W.D.3
  • 33
    • 31444438952 scopus 로고    scopus 로고
    • Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome
    • Maslak P., Chanel S., Camacho L.H., et al. Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome. Leukemia 2006, 20:212.
    • (2006) Leukemia , vol.20 , pp. 212
    • Maslak, P.1    Chanel, S.2    Camacho, L.H.3
  • 34
    • 51649110503 scopus 로고    scopus 로고
    • Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
    • Garcia-Manero G., Assouline S., Cortes J., et al. Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood 2008, 112:981.
    • (2008) Blood , vol.112 , pp. 981
    • Garcia-Manero, G.1    Assouline, S.2    Cortes, J.3
  • 35
    • 45949112533 scopus 로고    scopus 로고
    • Phase I/II study of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in higher-risk myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML)
    • Garcia-Manero G., Yang A.S., Klimek V., et al. Phase I/II study of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in higher-risk myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). ASH Annual Meeting Abstracts 2007, 110:444.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 444
    • Garcia-Manero, G.1    Yang, A.S.2    Klimek, V.3
  • 36
    • 77950538378 scopus 로고    scopus 로고
    • Anonymous, Available at:, Accessed February 17, 2010
    • Anonymous Methylgene press release October 27, 2008 Available at:, Accessed February 17, 2010. http://www.fiercebiotech.com/press-releases/methylgene-reacquires-rights-mgcd0103-celgene-implements-plan-focus-development-propr.
    • Methylgene press release October 27, 2008
  • 37
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G., Yang H., Bueso-Ramos C., et al. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008, 111:1060.
    • (2008) Blood , vol.111 , pp. 1060
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3
  • 38
    • 48749089341 scopus 로고    scopus 로고
    • Phase I study of suberoylanilide hydroxamic acid (SAHA) and decitabine in patients with relapsed, refractory or poor prognosis leukemia
    • Ravandi F., Faderl S., Thomas D., et al. Phase I study of suberoylanilide hydroxamic acid (SAHA) and decitabine in patients with relapsed, refractory or poor prognosis leukemia. ASH Annual Meeting Abstracts 2007, 110:897.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , pp. 897
    • Ravandi, F.1    Faderl, S.2    Thomas, D.3
  • 39
    • 12944268972 scopus 로고    scopus 로고
    • Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia
    • Faoro L.N., Tefferi A., Mesa R.A. Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia. Eur J Haematol 2005, 74:117.
    • (2005) Eur J Haematol , vol.74 , pp. 117
    • Faoro, L.N.1    Tefferi, A.2    Mesa, R.A.3
  • 40
    • 69249146365 scopus 로고    scopus 로고
    • Addition of cladribine to the standard daunorubicine - cytarabine (DA 3+7) remission induction protocol (DAC) contrary to adjunct of fludarabine (DAF) improves the overall survival in untreated adults with acute myeloid leukemia aged up to 60 Y: a multicenter, randomized, phase III PALG AML 1/2004 DAF/DAC/DA study in 673 patients
    • Holowiecki J., Grosicki S., Kyrcz-Krzemien S., et al. Addition of cladribine to the standard daunorubicine - cytarabine (DA 3+7) remission induction protocol (DAC) contrary to adjunct of fludarabine (DAF) improves the overall survival in untreated adults with acute myeloid leukemia aged up to 60 Y: a multicenter, randomized, phase III PALG AML 1/2004 DAF/DAC/DA study in 673 patients. ASH Annual Meeting Abstracts 2008, 112:133.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 133
    • Holowiecki, J.1    Grosicki, S.2    Kyrcz-Krzemien, S.3
  • 41
    • 6844237007 scopus 로고    scopus 로고
    • Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of poor-risk myelodysplastic syndromes and acute myeloid leukaemia
    • Parker J.E., Pagliuca A., Mijovic A., et al. Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of poor-risk myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol 1997, 99:939.
    • (1997) Br J Haematol , vol.99 , pp. 939
    • Parker, J.E.1    Pagliuca, A.2    Mijovic, A.3
  • 42
    • 35148887258 scopus 로고
    • Clofarabine: past, present, and future
    • Kantarjian H.M., Jeha S., Gandhi V., et al. Clofarabine: past, present, and future. Leuk Lymphoma 1922, 48:2007.
    • (1922) Leuk Lymphoma , vol.48 , pp. 2007
    • Kantarjian, H.M.1    Jeha, S.2    Gandhi, V.3
  • 43
    • 67649737744 scopus 로고    scopus 로고
    • Phase II study of single agent clofarabine in previously untreated older adult patients with acute myelogenous leukemia (AML) unlikely to benefit from standard induction chemotherapy
    • Erba H.P., Kantarjian H., Claxton D.F., et al. Phase II study of single agent clofarabine in previously untreated older adult patients with acute myelogenous leukemia (AML) unlikely to benefit from standard induction chemotherapy. ASH Annual Meeting Abstracts 2008, 112:558.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 558
    • Erba, H.P.1    Kantarjian, H.2    Claxton, D.F.3
  • 45
    • 66749161188 scopus 로고    scopus 로고
    • Oral (po) and intravenous (iv) clofarabine for patients (pts) with myelodysplastic syndrome (MDS)
    • Faderl S., Garcia-Manero G., Ravandi F., et al. Oral (po) and intravenous (iv) clofarabine for patients (pts) with myelodysplastic syndrome (MDS). ASH Annual Meeting Abstracts 2008, 112:222.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 222
    • Faderl, S.1    Garcia-Manero, G.2    Ravandi, F.3
  • 46
    • 67651102574 scopus 로고    scopus 로고
    • Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG
    • Martin M.G., Uy G.L., Procknow E., et al. Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG. Bone Marrow Transplant 2009, 44:13.
    • (2009) Bone Marrow Transplant , vol.44 , pp. 13
    • Martin, M.G.1    Uy, G.L.2    Procknow, E.3
  • 47
    • 77950526339 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation (allo-sct) for relapsed, refractory myeloid leukemia and MDS using clofarabine (clo) +/- fludarabine (flu) with iv busulfan (bu) as conditioning therapy. Presented at the BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #238].
    • Andersson BS, de Lima M, Popat U, et al. Allogeneic stem cell transplantation (allo-sct) for relapsed, refractory myeloid leukemia and MDS using clofarabine (clo) +/- fludarabine (flu) with iv busulfan (bu) as conditioning therapy. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #238].
    • (2009)
    • Andersson, B.S.1    de Lima, M.2    Popat, U.3
  • 48
    • 77950548370 scopus 로고    scopus 로고
    • Conditioning with clofarabine and busulfan x 4 (clobu4) for non-remission hematologic malignancies including AML is well tolerated, facilitates secure engraftment, and exhibits significant anti-tumor activity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February. [Abstract #287].
    • Magenau J, Pawarode A, Buck T, et al. Conditioning with clofarabine and busulfan x 4 (clobu4) for non-remission hematologic malignancies including AML is well tolerated, facilitates secure engraftment, and exhibits significant anti-tumor activity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #287].
    • (2009)
    • Magenau, J.1    Pawarode, A.2    Buck, T.3
  • 49
    • 77950525473 scopus 로고    scopus 로고
    • Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation (HCT) in patients with advanced hematologic malignancies: unexpected renal toxicity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, [Abstract #290].
    • van Besien K, Kline J, Godley L, et al. Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation (HCT) in patients with advanced hematologic malignancies: unexpected renal toxicity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #290].
    • (2009)
    • van Besien, K.1    Kline, J.2    Godley, L.3
  • 50
    • 69249238115 scopus 로고    scopus 로고
    • Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome
    • Raza A., Galili N., Smith S., et al. Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome. Blood 2009, 113:6533.
    • (2009) Blood , vol.113 , pp. 6533
    • Raza, A.1    Galili, N.2    Smith, S.3
  • 51
    • 0034978803 scopus 로고    scopus 로고
    • Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways
    • Ruscoe J.E., Rosario L.A., Wang T., et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther 2001, 298:339.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 339
    • Ruscoe, J.E.1    Rosario, L.A.2    Wang, T.3
  • 52
    • 67651167047 scopus 로고    scopus 로고
    • Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome
    • Raza A., Galili N., Callander N., et al. Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome. J Hematol Oncol 2009, 2:20.
    • (2009) J Hematol Oncol , vol.2 , pp. 20
    • Raza, A.1    Galili, N.2    Callander, N.3
  • 53
    • 0038054496 scopus 로고    scopus 로고
    • Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor
    • Gate L., Lunk A., Tew K.D. Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor. Biochem Pharmacol 2003, 65:1611.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1611
    • Gate, L.1    Lunk, A.2    Tew, K.D.3
  • 54
    • 0032731289 scopus 로고    scopus 로고
    • Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein
    • O'Brien M.L., Vulevic B., Freer S., et al. Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein. J Pharmacol Exp Ther 1999, 291:1348.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 1348
    • O'Brien, M.L.1    Vulevic, B.2    Freer, S.3
  • 55
    • 58449124096 scopus 로고    scopus 로고
    • Laromustine, a sulfonyl hydrolyzing alkylating prodrug for cancer therapy
    • Pigneux A. Laromustine, a sulfonyl hydrolyzing alkylating prodrug for cancer therapy. IDrugs 2009, 12:39.
    • (2009) IDrugs , vol.12 , pp. 39
    • Pigneux, A.1
  • 56
    • 33846413076 scopus 로고    scopus 로고
    • Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia
    • Giles F., Rizzieri D., Karp J., et al. Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia. J Clin Oncol 2007, 25:25.
    • (2007) J Clin Oncol , vol.25 , pp. 25
    • Giles, F.1    Rizzieri, D.2    Karp, J.3
  • 57
    • 33750022018 scopus 로고    scopus 로고
    • A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia
    • Giles F., Verstovsek S., Faderl S., et al. A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia. Leuk Res 2006, 30:1591.
    • (2006) Leuk Res , vol.30 , pp. 1591
    • Giles, F.1    Verstovsek, S.2    Faderl, S.3
  • 58
    • 27744493023 scopus 로고    scopus 로고
    • Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia
    • Giles F., Verstovsek S., Thomas D., et al. Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia. Clin Cancer Res 2005, 11:7817.
    • (2005) Clin Cancer Res , vol.11 , pp. 7817
    • Giles, F.1    Verstovsek, S.2    Thomas, D.3
  • 59
    • 23844505374 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors in myelodysplastic syndrome
    • Feldman E.J. Farnesyltransferase inhibitors in myelodysplastic syndrome. Curr Hematol Rep 2005, 4:186.
    • (2005) Curr Hematol Rep , vol.4 , pp. 186
    • Feldman, E.J.1
  • 60
    • 33947361191 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines
    • Medeiros B.C., Landau H.J., Morrow M., et al. The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia 2007, 21:739.
    • (2007) Leukemia , vol.21 , pp. 739
    • Medeiros, B.C.1    Landau, H.J.2    Morrow, M.3
  • 61
    • 2142712474 scopus 로고    scopus 로고
    • Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome
    • Kurzrock R., Albitar M., Cortes J.E., et al. Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome. J Clin Oncol 2004, 22:1287.
    • (2004) J Clin Oncol , vol.22 , pp. 1287
    • Kurzrock, R.1    Albitar, M.2    Cortes, J.E.3
  • 62
    • 34248363673 scopus 로고    scopus 로고
    • A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
    • Fenaux P., Raza A., Mufti G.J., et al. A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome. Blood 2007, 109:4158.
    • (2007) Blood , vol.109 , pp. 4158
    • Fenaux, P.1    Raza, A.2    Mufti, G.J.3
  • 63
    • 38949159210 scopus 로고    scopus 로고
    • Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome
    • Kurzrock R., Kantarjian H.M., Blascovich M.A., et al. Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome. Clin Cancer Res 2008, 14:509.
    • (2008) Clin Cancer Res , vol.14 , pp. 509
    • Kurzrock, R.1    Kantarjian, H.M.2    Blascovich, M.A.3
  • 64
    • 53549126061 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitor (lonafarnib) in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia: a phase II study
    • Ravoet C., Mineur P., Robin V., et al. Farnesyl transferase inhibitor (lonafarnib) in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia: a phase II study. Ann Hematol 2008, 87:881.
    • (2008) Ann Hematol , vol.87 , pp. 881
    • Ravoet, C.1    Mineur, P.2    Robin, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.