-
1
-
-
30144443817
-
The myelodysplastic syndromes: diagnosis and treatment
-
Steensma D.P., Bennett J.M. The myelodysplastic syndromes: diagnosis and treatment. Mayo Clin Proc 2006, 81:104.
-
(2006)
Mayo Clin Proc
, vol.81
, pp. 104
-
-
Steensma, D.P.1
Bennett, J.M.2
-
2
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
-
Fenaux P., Mufti G.J., Hellstrom-Lindberg E., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10:223.
-
(2009)
Lancet Oncol
, vol.10
, pp. 223
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
3
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
-
Kantarjian H., Issa J.P., Rosenfeld C.S., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006, 106:1794.
-
(2006)
Cancer
, vol.106
, pp. 1794
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
-
4
-
-
33749438404
-
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
-
List A., Dewald G., Bennett J., et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006, 355:1456.
-
(2006)
N Engl J Med
, vol.355
, pp. 1456
-
-
List, A.1
Dewald, G.2
Bennett, J.3
-
5
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
-
Silverman L.R., Demakos E.P., Peterson B.L., et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002, 20:2429.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
6
-
-
55049098618
-
Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches
-
Gore S.D., Hermes-DeSantis E.R. Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches. Cancer Control 2008, 15(Suppl):40.
-
(2008)
Cancer Control
, vol.15
, Issue.SUPPL.
, pp. 40
-
-
Gore, S.D.1
Hermes-DeSantis, E.R.2
-
7
-
-
37549022694
-
DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
-
Griffiths E.A., Gore S.D. DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol 2008, 45:23.
-
(2008)
Semin Hematol
, vol.45
, pp. 23
-
-
Griffiths, E.A.1
Gore, S.D.2
-
9
-
-
40549130642
-
Cracking the enigmatic linker histone code
-
Godde J.S., Ura K. Cracking the enigmatic linker histone code. J Biochem 2008, 143:287.
-
(2008)
J Biochem
, vol.143
, pp. 287
-
-
Godde, J.S.1
Ura, K.2
-
10
-
-
67249116835
-
Targeting histone deacetylases for the treatment of disease
-
Lawless M.W., Norris S., O'Byrne K.J., et al. Targeting histone deacetylases for the treatment of disease. J Cell Mol Med 2009, 13:826.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 826
-
-
Lawless, M.W.1
Norris, S.2
O'Byrne, K.J.3
-
11
-
-
34249033131
-
Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application
-
Santini V., Gozzini A., Ferrari G. Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 2007, 8:383.
-
(2007)
Curr Drug Metab
, vol.8
, pp. 383
-
-
Santini, V.1
Gozzini, A.2
Ferrari, G.3
-
12
-
-
49349107518
-
Lysine acetylation: codified crosstalk with other posttranslational modifications
-
Yang X.J., Seto E. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 2008, 31:449.
-
(2008)
Mol Cell
, vol.31
, pp. 449
-
-
Yang, X.J.1
Seto, E.2
-
13
-
-
33845627416
-
Acetylation and histone deacetylase inhibitors in cancer
-
Kortenhorst M.S., Carducci M.A., Shabbeer S. Acetylation and histone deacetylase inhibitors in cancer. Cell Oncol 2006, 28:191.
-
(2006)
Cell Oncol
, vol.28
, pp. 191
-
-
Kortenhorst, M.S.1
Carducci, M.A.2
Shabbeer, S.3
-
14
-
-
47249100271
-
Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents
-
Moradei O., Vaisburg A., Martell R.E. Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents. Curr Top Med Chem 2008, 8:841.
-
(2008)
Curr Top Med Chem
, vol.8
, pp. 841
-
-
Moradei, O.1
Vaisburg, A.2
Martell, R.E.3
-
15
-
-
69449093587
-
HDAC inhibitor-based therapies and haematological malignancy
-
Stimson L., Wood V., Khan O., et al. HDAC inhibitor-based therapies and haematological malignancy. Ann Oncol 2009, 20:1293.
-
(2009)
Ann Oncol
, vol.20
, pp. 1293
-
-
Stimson, L.1
Wood, V.2
Khan, O.3
-
16
-
-
70350720044
-
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
-
Figueroa M.E., Skrabanek L., Li Y., et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood 2009, 114(16):3448-3458.
-
(2009)
Blood
, vol.114
, Issue.16
, pp. 3448-3458
-
-
Figueroa, M.E.1
Skrabanek, L.2
Li, Y.3
-
17
-
-
46949098033
-
Current status of epigenetic treatment in myelodysplastic syndromes
-
Kuendgen A., Lubbert M. Current status of epigenetic treatment in myelodysplastic syndromes. Ann Hematol 2008, 87:601.
-
(2008)
Ann Hematol
, vol.87
, pp. 601
-
-
Kuendgen, A.1
Lubbert, M.2
-
18
-
-
67651153048
-
New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
-
Cang S., Ma Y., Liu D. New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer. J Hematol Oncol 2009, 2:22.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 22
-
-
Cang, S.1
Ma, Y.2
Liu, D.3
-
19
-
-
33947581039
-
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias
-
Gojo I., Jiemjit A., Trepel J.B., et al. Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias. Blood 2007, 109:2781.
-
(2007)
Blood
, vol.109
, pp. 2781
-
-
Gojo, I.1
Jiemjit, A.2
Trepel, J.B.3
-
20
-
-
34848819070
-
Combined methyltransferase/histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMoL and AML: clinical response, histone acetylation and DNA damage
-
Gore S.D., Jiemjit A., Silverman L.B., et al. Combined methyltransferase/histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMoL and AML: clinical response, histone acetylation and DNA damage. ASH Annual Meeting Abstracts 2006, 108:517.
-
(2006)
ASH Annual Meeting Abstracts
, vol.108
, pp. 517
-
-
Gore, S.D.1
Jiemjit, A.2
Silverman, L.B.3
-
21
-
-
49349104503
-
A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia
-
Gimsing P., Hansen M., Knudsen L.M., et al. A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia. Eur J Haematol 2008, 81:170.
-
(2008)
Eur J Haematol
, vol.81
, pp. 170
-
-
Gimsing, P.1
Hansen, M.2
Knudsen, L.M.3
-
22
-
-
38949144400
-
Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes
-
Klimek V.M., Fircanis S., Maslak P., et al. Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes. Clin Cancer Res 2008, 14:826.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 826
-
-
Klimek, V.M.1
Fircanis, S.2
Maslak, P.3
-
23
-
-
67449109154
-
Phase IA/II study of oral panobinostat (lbh589), a novel pan- deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies
-
Ottmann O.G., Spencer A., Prince H.M., et al. Phase IA/II study of oral panobinostat (lbh589), a novel pan- deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies. ASH Annual Meeting Abstracts 2008, 112:958.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 958
-
-
Ottmann, O.G.1
Spencer, A.2
Prince, H.M.3
-
24
-
-
34347376811
-
Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukemia
-
Kalff A., Shortt J., Farr J., et al. Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukemia. ASH Annual Meeting Abstracts 2006, 108:4554.
-
(2006)
ASH Annual Meeting Abstracts
, vol.108
, pp. 4554
-
-
Kalff, A.1
Shortt, J.2
Farr, J.3
-
25
-
-
18244383806
-
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
-
Gottlicher M., Minucci S., Zhu P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001, 20:6969.
-
(2001)
EMBO J
, vol.20
, pp. 6969
-
-
Gottlicher, M.1
Minucci, S.2
Zhu, P.3
-
26
-
-
66749108988
-
Randomized phase ii study of combined epigenetic therapy: decitabine vs. decitabine and valproic acid in MDS and AML
-
Issa J.P., Castoro R., Ravandi-Kashani F., et al. Randomized phase ii study of combined epigenetic therapy: decitabine vs. decitabine and valproic acid in MDS and AML. ASH Annual Meeting Abstracts 2008, 112:228.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 228
-
-
Issa, J.P.1
Castoro, R.2
Ravandi-Kashani, F.3
-
27
-
-
35748962020
-
Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes
-
Siitonen T., Timonen T., Juvonen E., et al. Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes. Haematologica 2007, 92:1119.
-
(2007)
Haematologica
, vol.92
, pp. 1119
-
-
Siitonen, T.1
Timonen, T.2
Juvonen, E.3
-
28
-
-
29144481615
-
Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia
-
Kuendgen A., Knipp S., Fox F., et al. Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia. Ann Hematol 2005, 84(Suppl 13):61.
-
(2005)
Ann Hematol
, vol.84
, Issue.13 SUPPL.
, pp. 61
-
-
Kuendgen, A.1
Knipp, S.2
Fox, F.3
-
29
-
-
29144484694
-
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia
-
Bug G., Ritter M., Wassmann B., et al. Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia. Cancer 2005, 104:2717.
-
(2005)
Cancer
, vol.104
, pp. 2717
-
-
Bug, G.1
Ritter, M.2
Wassmann, B.3
-
30
-
-
33750530675
-
Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia
-
Garcia-Manero G., Kantarjian H.M., Sanchez-Gonzalez B., et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood 2006, 108:3271.
-
(2006)
Blood
, vol.108
, pp. 3271
-
-
Garcia-Manero, G.1
Kantarjian, H.M.2
Sanchez-Gonzalez, B.3
-
31
-
-
68049120458
-
Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes
-
Voso M.T., Santini V., Finelli C., et al. Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. Clin Cancer Res 2009, 15:5002.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5002
-
-
Voso, M.T.1
Santini, V.2
Finelli, C.3
-
32
-
-
0036554808
-
Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia
-
Gore S.D., Weng L.J., Figg W.D., et al. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clin Cancer Res 2002, 8:963.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 963
-
-
Gore, S.D.1
Weng, L.J.2
Figg, W.D.3
-
33
-
-
31444438952
-
Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome
-
Maslak P., Chanel S., Camacho L.H., et al. Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome. Leukemia 2006, 20:212.
-
(2006)
Leukemia
, vol.20
, pp. 212
-
-
Maslak, P.1
Chanel, S.2
Camacho, L.H.3
-
34
-
-
51649110503
-
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
-
Garcia-Manero G., Assouline S., Cortes J., et al. Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood 2008, 112:981.
-
(2008)
Blood
, vol.112
, pp. 981
-
-
Garcia-Manero, G.1
Assouline, S.2
Cortes, J.3
-
35
-
-
45949112533
-
Phase I/II study of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in higher-risk myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML)
-
Garcia-Manero G., Yang A.S., Klimek V., et al. Phase I/II study of MGCD0103, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in higher-risk myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). ASH Annual Meeting Abstracts 2007, 110:444.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 444
-
-
Garcia-Manero, G.1
Yang, A.S.2
Klimek, V.3
-
36
-
-
77950538378
-
-
Anonymous, Available at:, Accessed February 17, 2010
-
Anonymous Methylgene press release October 27, 2008 Available at:, Accessed February 17, 2010. http://www.fiercebiotech.com/press-releases/methylgene-reacquires-rights-mgcd0103-celgene-implements-plan-focus-development-propr.
-
Methylgene press release October 27, 2008
-
-
-
37
-
-
38949096781
-
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
-
Garcia-Manero G., Yang H., Bueso-Ramos C., et al. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008, 111:1060.
-
(2008)
Blood
, vol.111
, pp. 1060
-
-
Garcia-Manero, G.1
Yang, H.2
Bueso-Ramos, C.3
-
38
-
-
48749089341
-
Phase I study of suberoylanilide hydroxamic acid (SAHA) and decitabine in patients with relapsed, refractory or poor prognosis leukemia
-
Ravandi F., Faderl S., Thomas D., et al. Phase I study of suberoylanilide hydroxamic acid (SAHA) and decitabine in patients with relapsed, refractory or poor prognosis leukemia. ASH Annual Meeting Abstracts 2007, 110:897.
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, pp. 897
-
-
Ravandi, F.1
Faderl, S.2
Thomas, D.3
-
39
-
-
12944268972
-
Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia
-
Faoro L.N., Tefferi A., Mesa R.A. Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia. Eur J Haematol 2005, 74:117.
-
(2005)
Eur J Haematol
, vol.74
, pp. 117
-
-
Faoro, L.N.1
Tefferi, A.2
Mesa, R.A.3
-
40
-
-
69249146365
-
Addition of cladribine to the standard daunorubicine - cytarabine (DA 3+7) remission induction protocol (DAC) contrary to adjunct of fludarabine (DAF) improves the overall survival in untreated adults with acute myeloid leukemia aged up to 60 Y: a multicenter, randomized, phase III PALG AML 1/2004 DAF/DAC/DA study in 673 patients
-
Holowiecki J., Grosicki S., Kyrcz-Krzemien S., et al. Addition of cladribine to the standard daunorubicine - cytarabine (DA 3+7) remission induction protocol (DAC) contrary to adjunct of fludarabine (DAF) improves the overall survival in untreated adults with acute myeloid leukemia aged up to 60 Y: a multicenter, randomized, phase III PALG AML 1/2004 DAF/DAC/DA study in 673 patients. ASH Annual Meeting Abstracts 2008, 112:133.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 133
-
-
Holowiecki, J.1
Grosicki, S.2
Kyrcz-Krzemien, S.3
-
41
-
-
6844237007
-
Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of poor-risk myelodysplastic syndromes and acute myeloid leukaemia
-
Parker J.E., Pagliuca A., Mijovic A., et al. Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of poor-risk myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol 1997, 99:939.
-
(1997)
Br J Haematol
, vol.99
, pp. 939
-
-
Parker, J.E.1
Pagliuca, A.2
Mijovic, A.3
-
42
-
-
35148887258
-
Clofarabine: past, present, and future
-
Kantarjian H.M., Jeha S., Gandhi V., et al. Clofarabine: past, present, and future. Leuk Lymphoma 1922, 48:2007.
-
(1922)
Leuk Lymphoma
, vol.48
, pp. 2007
-
-
Kantarjian, H.M.1
Jeha, S.2
Gandhi, V.3
-
43
-
-
67649737744
-
Phase II study of single agent clofarabine in previously untreated older adult patients with acute myelogenous leukemia (AML) unlikely to benefit from standard induction chemotherapy
-
Erba H.P., Kantarjian H., Claxton D.F., et al. Phase II study of single agent clofarabine in previously untreated older adult patients with acute myelogenous leukemia (AML) unlikely to benefit from standard induction chemotherapy. ASH Annual Meeting Abstracts 2008, 112:558.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 558
-
-
Erba, H.P.1
Kantarjian, H.2
Claxton, D.F.3
-
44
-
-
77950529271
-
-
Anonymous, September 1, Genzyme Press, Available at:, Accessed September 22, 2009
-
Anonymous FDA Advisory Committee recommends randomized trial to support proposed indication for clolar in adult AML September 1, 2009, Genzyme Press, Available at:, Accessed September 22, 2009. http://www.genzyme.com/corp/media/GENZ%20PR-090109.asp.
-
(2009)
FDA Advisory Committee recommends randomized trial to support proposed indication for clolar in adult AML
-
-
-
45
-
-
66749161188
-
Oral (po) and intravenous (iv) clofarabine for patients (pts) with myelodysplastic syndrome (MDS)
-
Faderl S., Garcia-Manero G., Ravandi F., et al. Oral (po) and intravenous (iv) clofarabine for patients (pts) with myelodysplastic syndrome (MDS). ASH Annual Meeting Abstracts 2008, 112:222.
-
(2008)
ASH Annual Meeting Abstracts
, vol.112
, pp. 222
-
-
Faderl, S.1
Garcia-Manero, G.2
Ravandi, F.3
-
46
-
-
67651102574
-
Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG
-
Martin M.G., Uy G.L., Procknow E., et al. Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG. Bone Marrow Transplant 2009, 44:13.
-
(2009)
Bone Marrow Transplant
, vol.44
, pp. 13
-
-
Martin, M.G.1
Uy, G.L.2
Procknow, E.3
-
47
-
-
77950526339
-
-
Allogeneic stem cell transplantation (allo-sct) for relapsed, refractory myeloid leukemia and MDS using clofarabine (clo) +/- fludarabine (flu) with iv busulfan (bu) as conditioning therapy. Presented at the BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #238].
-
Andersson BS, de Lima M, Popat U, et al. Allogeneic stem cell transplantation (allo-sct) for relapsed, refractory myeloid leukemia and MDS using clofarabine (clo) +/- fludarabine (flu) with iv busulfan (bu) as conditioning therapy. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #238].
-
(2009)
-
-
Andersson, B.S.1
de Lima, M.2
Popat, U.3
-
48
-
-
77950548370
-
-
Conditioning with clofarabine and busulfan x 4 (clobu4) for non-remission hematologic malignancies including AML is well tolerated, facilitates secure engraftment, and exhibits significant anti-tumor activity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February. [Abstract #287].
-
Magenau J, Pawarode A, Buck T, et al. Conditioning with clofarabine and busulfan x 4 (clobu4) for non-remission hematologic malignancies including AML is well tolerated, facilitates secure engraftment, and exhibits significant anti-tumor activity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #287].
-
(2009)
-
-
Magenau, J.1
Pawarode, A.2
Buck, T.3
-
49
-
-
77950525473
-
-
Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation (HCT) in patients with advanced hematologic malignancies: unexpected renal toxicity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, [Abstract #290].
-
van Besien K, Kline J, Godley L, et al. Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation (HCT) in patients with advanced hematologic malignancies: unexpected renal toxicity. Presented at the 2009 BMT Tandem Meeting. Tampa, Florida, February, 2009. [Abstract #290].
-
(2009)
-
-
van Besien, K.1
Kline, J.2
Godley, L.3
-
50
-
-
69249238115
-
Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome
-
Raza A., Galili N., Smith S., et al. Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome. Blood 2009, 113:6533.
-
(2009)
Blood
, vol.113
, pp. 6533
-
-
Raza, A.1
Galili, N.2
Smith, S.3
-
51
-
-
0034978803
-
Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways
-
Ruscoe J.E., Rosario L.A., Wang T., et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther 2001, 298:339.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 339
-
-
Ruscoe, J.E.1
Rosario, L.A.2
Wang, T.3
-
52
-
-
67651167047
-
Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome
-
Raza A., Galili N., Callander N., et al. Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(R), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome. J Hematol Oncol 2009, 2:20.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 20
-
-
Raza, A.1
Galili, N.2
Callander, N.3
-
53
-
-
0038054496
-
Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor
-
Gate L., Lunk A., Tew K.D. Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor. Biochem Pharmacol 2003, 65:1611.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1611
-
-
Gate, L.1
Lunk, A.2
Tew, K.D.3
-
54
-
-
0032731289
-
Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein
-
O'Brien M.L., Vulevic B., Freer S., et al. Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein. J Pharmacol Exp Ther 1999, 291:1348.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 1348
-
-
O'Brien, M.L.1
Vulevic, B.2
Freer, S.3
-
55
-
-
58449124096
-
Laromustine, a sulfonyl hydrolyzing alkylating prodrug for cancer therapy
-
Pigneux A. Laromustine, a sulfonyl hydrolyzing alkylating prodrug for cancer therapy. IDrugs 2009, 12:39.
-
(2009)
IDrugs
, vol.12
, pp. 39
-
-
Pigneux, A.1
-
56
-
-
33846413076
-
Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia
-
Giles F., Rizzieri D., Karp J., et al. Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia. J Clin Oncol 2007, 25:25.
-
(2007)
J Clin Oncol
, vol.25
, pp. 25
-
-
Giles, F.1
Rizzieri, D.2
Karp, J.3
-
57
-
-
33750022018
-
A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia
-
Giles F., Verstovsek S., Faderl S., et al. A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia. Leuk Res 2006, 30:1591.
-
(2006)
Leuk Res
, vol.30
, pp. 1591
-
-
Giles, F.1
Verstovsek, S.2
Faderl, S.3
-
58
-
-
27744493023
-
Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia
-
Giles F., Verstovsek S., Thomas D., et al. Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia. Clin Cancer Res 2005, 11:7817.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7817
-
-
Giles, F.1
Verstovsek, S.2
Thomas, D.3
-
59
-
-
23844505374
-
Farnesyltransferase inhibitors in myelodysplastic syndrome
-
Feldman E.J. Farnesyltransferase inhibitors in myelodysplastic syndrome. Curr Hematol Rep 2005, 4:186.
-
(2005)
Curr Hematol Rep
, vol.4
, pp. 186
-
-
Feldman, E.J.1
-
60
-
-
33947361191
-
The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines
-
Medeiros B.C., Landau H.J., Morrow M., et al. The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia 2007, 21:739.
-
(2007)
Leukemia
, vol.21
, pp. 739
-
-
Medeiros, B.C.1
Landau, H.J.2
Morrow, M.3
-
61
-
-
2142712474
-
Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome
-
Kurzrock R., Albitar M., Cortes J.E., et al. Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome. J Clin Oncol 2004, 22:1287.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1287
-
-
Kurzrock, R.1
Albitar, M.2
Cortes, J.E.3
-
62
-
-
34248363673
-
A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
-
Fenaux P., Raza A., Mufti G.J., et al. A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome. Blood 2007, 109:4158.
-
(2007)
Blood
, vol.109
, pp. 4158
-
-
Fenaux, P.1
Raza, A.2
Mufti, G.J.3
-
63
-
-
38949159210
-
Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome
-
Kurzrock R., Kantarjian H.M., Blascovich M.A., et al. Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome. Clin Cancer Res 2008, 14:509.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 509
-
-
Kurzrock, R.1
Kantarjian, H.M.2
Blascovich, M.A.3
-
64
-
-
53549126061
-
Farnesyl transferase inhibitor (lonafarnib) in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia: a phase II study
-
Ravoet C., Mineur P., Robin V., et al. Farnesyl transferase inhibitor (lonafarnib) in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia: a phase II study. Ann Hematol 2008, 87:881.
-
(2008)
Ann Hematol
, vol.87
, pp. 881
-
-
Ravoet, C.1
Mineur, P.2
Robin, V.3
|