Schistosoma mansoni: In vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula

Experimental Parasitology

Volumn 132, Issue 2, 2012, Pages 222-227

  de Moraes, Josué ^a,b   Nascimento, Carlos ^a   Yamaguchi, Lydia F ^c   Kato, Massuo J ^c   Nakano, Eliana ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b SUVIS Casa Verde   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Natural product; Piplartine; Schistosoma mansoni; Schistosomicidal activity; Schistosomula

Indexed keywords

NATURAL PRODUCT; PIPLARTINE; PRAZIQUANTEL; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANTHELMINTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; MALE; NONHUMAN; PIPER TUBERCULATUM; PIPERACEAE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHISTOSOMA MANSONI; SCHISTOSOMULUM; WORM TEGUMENT;

ANIMALS; BIOMPHALARIA; CRICETINAE; LARVA; MESOCRICETUS; MICROSCOPY, CONFOCAL; PIPER; PIPERIDONES; PLANT EXTRACTS; PRAZIQUANTEL; SCHISTOSOMA MANSONI; SCHISTOSOMICIDES; TIME FACTORS;

PIPERACEAE; SCHISTOSOMA MANSONI;

EID: 84866357922     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2012.07.004     Document Type: Article

References (44)

1. Basch P.F. Cultivation of Schistosoma mansoni in vitro. I. Establishment of cultures from cercariae and development until pairing. Journal of Parasitology 1981, 67:179-185.
2. Basch P.F., Basch N. Schistosoma mansoni: scanning electron microscopy of schistosomula, adults and eggs grown in vitro. Parasitology 1982, 85:333-338.
3. Bezerra D.P., Pessoa C., de Moraes M.O., Silveira E.R., Lima M.A., Elmiro F.J., Costa-Lotufo L.V. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Zeitschrift für Naturforschung C. Journal of Biosciences 2005, 60:539-543.
4. Bezerra D.P., Castro F.O., Alves A.P., Pessoa C., Moraes M.O., Silveira E.R., Lima M.A., Elmiro F.J., Costa-Lotufo L.V. In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Brazilian Journal of Medical and Biological Research 2006, 39:801-807.
5. Bezerra D.P., Militão G.C., de Castro F.O., Pessoa C., de Moraes M.O., Silveira E.R., Lima M.A., Elmiro F.J., Costa-Lotufo L.V. Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways. Toxicology in Vitro 2007, 21:1-8.
6. Bezerra D.P., de Castro F.O., Alves A.P., Pessoa C., de Moraes M.O., Silveira E.R., Lima M.A., Elmiro F.J., de Alencar N.M., Mesquita R.O., Lima M.W., Costa-Lotufo L.V. In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. Journal of Applied Toxicology 2008, 28:156-163.
7. Bezerra D.P., Moura D.J., Rosa R.M., de Vasconcellos M.C., de Silva A.C., de Moraes M.O., Silveira E.R., Lima M.A., Henriques J.A., Costa-Lotufo L.V., Saffi J. Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells. Mutation Research 2008, 652:164-174.
8. Bezerra D.P., Vasconcellos M.C., Machado M.S., Villela I.V., Rosa R.M., Moura D.J., Pessoa C., Moraes M.O., Silveira E.R., Lima M.A., Aquino N.C., Henriques J.A., Saffi J., Costa-Lotufo L.V. Piplartine induces genotoxicity in eukaryotic but not in prokaryotic model systems. Mutation Research 2009, 677:8-13.
9. Bodiwala H.S., Singh G., Singh R., Dey C.S., Sharma S.S., Bhutani K.K., Singh I.P. Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum. Journal of Natural Medicines 2007, 61:418-421.
10. Crabtree J.E., Wilson R.A. Schistosoma mansoni: a scanning electron microscope study of the developing schistosomulum. Parasitology 1980, 81:553-564.
11. Caffrey C.R. Chemotherapy of schistosomiasis: present and future. Current Opinion in Chemical Biology 2007, 11:433-439.
12. Caixeta S.C., Magalhães L.G., de Melo N.I., Wakabayashi K.A., de P Aguiar G., de P Aguiar D., Mantovani A.L., Alves J.M., Oliveira P.F., Tavares D.C., Groppo M., Rodrigues V., Cunha W.R., Veneziani R.C., da Silva Filho A.A., Crotti A.E. Chemical composition and in vitro schistosomicidal activity of the essential oil of Plectranthus neochilus grown in Southeast Brazil. Chemistry & Biodiversity 2011, 8:2149-2157.
13. Cícero Bezerra Felipe F., Trajano Sousa Filho J., de Oliveira Souza L.E., Alexandre Silveira J., de Andrade Esdras, Uchoa D., Rocha Silveira E., Deusdênia Loiola Pessoa O., de Barros Viana G.S. Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice. Phytomedicine 2007, 14:605-612.
14. Cioli D., Pica-Mattoccia L., Archer S. Antischistosomal drugs: past, present and future?. Pharmacology & Therapeutics 1995, 68:35-85.
15. Cotinguiba F., Regasini L.O., da Silva Bolzani V., Debonsi H.M., Duó Passerini G., Cicarelli R.M.B., Kato M.J., Furlan M. Piperamides and their derivatives as potential anti-trypanosomal agents. Medicinal Chemistry Research 2009, 18:703-711.
16. de Moraes J., Nascimento C., Miura L.M., Leite J.R., Nakano E., Kawano T. Evaluation of the in vitro activity of dermaseptin 01, a cationic antimicrobial peptide, against Schistosoma mansoni. Chemistry & Biodiversity 2011, 8:548-558.
17. Doenhoff M., Cioli D., Utzinger J. Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Current Opinion in Infectious Diseases 2008, 21:659-667.
18. Fontenele J.B., Leal L.K., Silveira E.R., Felix F.H., Bezerra Felipe C.F., Viana G.S. Antiplatelet effects of piplartine, an alkamide isolated from Piper tuberculatum: possible involvement of cyclooxygenase blockade and antioxidant activity. The Journal of Pharmacy and Pharmacology 2009, 61:511-515.
19. Geary T.G., Klein R.D., Vanover L., Bowman J.W., Thompson D.P. The nervous systems of helminths as targets for drugs. Journal of Parasitology 1992, 78:215-230.
20. Gryseels B., Polman K., Clerinx J., Kestens L. Human schistosomiasis. Lancet 2006, 368:1106-1118.
21. Harrop R., Wilson R.A. Protein synthesis and release by cultured schistosomula of Schistosoma mansoni. Parasitology 1993, 107:265-274.
22. Jaramillo M.A., Manos P.S. Phylogeny and patterns of floral diversity in the genus Piper (Piperaceae). American Journal of Botany 2001, 88:706-716.
23. King C.H. Parasites and poverty: the case of schistosomiasis. Acta Tropica 2010, 113:95-104.
24. King C.H., Dickman K., Tisch D.J. Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 2005, 365:1561-1569.
25. Magalhães L.G., Machado C.B., Morais E.R., Moreira E.B., Soares C.S., da Silva S.H., da Silva Filho A.A., Rodrigues V. In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. Parasitology Research 2009, 104:1197-1201.
26. Magalhães L.G., Kapadia G.J., da Silva Tonuci L.R., Caixeta S.C., Parreira N.A., Rodrigues V., Da Silva Filho A.A. In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms. Parasitology Research 2010, 106:395-401.
27. Manneck T., Haggenmüller Y., Keiser J. Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology 2010, 137:85-98.
28. Moraes J. Antischistosomal natural compounds: present challenges for new drug screens. Current Topics in Tropical Medicine 2012, 333-358. Intech, Rijeka. A.J. Rodriguez-Morales (Ed.).
29. Moraes J., Silva M.P., Ohlweiler F.P., Kawano T. Schistosoma mansoni and other larval trematodes in Biomphalaria tenagophila (Planorbidae) from Guarulhos, São Paulo State, Brazil. Revista do Instituto de Medicina Tropical de São Paulo 2009, 51:77-82.
30. Moraes J., Nascimento C., Lopes P.O., Nakano E., Yamaguchi L.F., Kato M.J., Kawano T. Schistosoma mansoni: In vitro schistosomicidal activity of piplartine. Experimental Parasitology 2011, 127:357-364.
31. Navickiene H.M., Alécio A.C., Kato M.J., Bolzani V.D., Young M.C., Cavalheiro A.J., Furlan M. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 2000, 55:621-626.
32. Navickiene H.M., Bolzani V da S., Kato M.J., Pereira A.M., Bertoni B.W., França S.C., Furlan M. Quantitative determination of anti-fungal and insecticide amides in adult plants, plantlets and callus from Piper tuberculatum by reverse-phase high-performance liquid chromatography. Phytochemical Analysis 2003, 14:281-284.
33. Pereira A.C., Magalhães L.G., Gonçalves U.O., Luz P.P., Moraes A.C., Rodrigues V., da Matta Guedes P.M., da Silva Filho A.A., Cunha W.R., Bastos J.K., Nanayakkara N.P., de Silva M.L. Schistosomicidal and trypanocidal structure-activity relationships for (±)-licarin A and its (-)- and (+)-enantiomers. Phytochemistry 2011, 72:1424-1430.
34. Ramalho-Pinto F.J., Gazzinelli G., Howells R.E., Mota-Santos T.A., Figueiredo E.A., Pellegrino J. Schistosoma mansoni: defined system for stepwise transformation of cercaria to schistosomule in vitro. Experimental Parasitology 1974, 36:360-372.
35. Rodrigues R.V., Lanznaster D., Longhi Balbinot D.T., Gadotti Vde M., Facundo V.A., Santos A.R. Antinociceptive effect of crude extract, fractions and three alkaloids obtained from fruits of Piper tuberculatum. Biological & Pharmaceutical Bulletin 2009, 32:1809-1812.
36. Sangster N.C., Song J., Demeler J. Resistance as a tool for discovering and understanding targets in parasite neuromusculature. Parasitology 2005, 131(Suppl):S179-S190.
37. Skelly P.J., Alan Wilson R. Making sense of the schistosome surface. Advances in Parasitology 2006, 63:185-284.
38. Steinmann P., Keiser J., Bos R., Tanner M., Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. The Lancet Infectious Diseases 2006, 6:411-425.
39. Thompson D.P., Klein R.D., Geary T.G. Prospects for rational approaches to anthelmintic discovery. Parasitology 1996, 113(Suppl):S217-S238.
40. Tsai I.L., Lee F.P., Wu C.C., Duh C.Y., Ishikawa T., Chen J.J., Chen Y.C., Seki H., Chen I.S. New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Planta Medica 2005, 71:535-542.
41. Utzinger J., Keiser J., Shuhua X., Tanner M., Singer B.H. Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials. Antimicrobial Agents and Chemotherapy 2003, 47:1487-1495.
42. van der Werf M.J., de Vlas S.J., Brooker S., Looman C.W., Nagelkerke N.J., Habbema J.D., Engels D. Quantification of clinical morbidity associated with schistosome infection. Acta Tropica 2003, 86:125-139.
43. Vasques da Silva R., Navickiene H.M., Kato M.J., Bolzani V.da S., Méda C.I., Young M.C., Furlan M. Antifungal amides from Piper arboreum and Piper tuberculatum. Phytochemistry 2002, 59:521-527.
44. Veras L.M., Guimarães M.A., Campelo Y.D., Vieira M.M., Nascimento C., Lima D., Vasconcelos L., Nakano E., Kuckelhaus S., Batista M.C., Leite J.R., Moraes J. Activity of epiisopiloturine against Schistosoma mansoni. Current Medicinal Chemistry 2012, 19:2051-2058.