메뉴 건너뛰기




Volumn 61, Issue 4, 2009, Pages 511-515

Antiplatelet effects of piplartine, an alkamide isolated from Piper tuberculatum: Possible involvement of cyclooxygenase blockade and antioxidant activity

Author keywords

Antiplatelet effects; Piper tuberculatum; Piplartine; Platelet aggregation

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ALKALOID; ARACHIDONIC ACID; ARGININE; COLLAGEN; NITRIC OXIDE SYNTHASE; PENTOXIFYLLINE; PIPLARTINE; PROSTAGLANDIN SYNTHASE; THROMBIN; TICLOPIDINE; UNCLASSIFIED DRUG; ANTIOXIDANT; PIPERIDONE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR;

EID: 66449110250     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.04.0014     Document Type: Article
Times cited : (37)

References (43)
  • 1
    • 0028070593 scopus 로고
    • Fibrinogen receptor antagonists - a novel class of promising antithrombotics
    • Weller T et al. Fibrinogen receptor antagonists - a novel class of promising antithrombotics. Drugs Future 1994; 19: 461-476.
    • (1994) Drugs Future , vol.19 , pp. 461-476
    • Weller, T.1
  • 2
    • 2342638446 scopus 로고    scopus 로고
    • Atherothrombosis: Epidemiology, pathophysiology, and prevention
    • Munger MA, Hawkins DWJ. Atherothrombosis: epidemiology, pathophysiology, and prevention. J Am Pharm Assoc 2004; 44: S5-S12.
    • (2004) J Am Pharm Assoc , vol.44
    • Munger, M.A.1    Hawkins, D.W.J.2
  • 4
    • 0032428124 scopus 로고    scopus 로고
    • Antiplatelet agents isolated from medicinal plants
    • Teng CM, Ko FN. Antiplatelet agents isolated from medicinal plants. Res Comm Mol Pathol Pharmacol 1998; 102: 211-225.
    • (1998) Res Comm Mol Pathol Pharmacol , vol.102 , pp. 211-225
    • Teng, C.M.1    Ko, F.N.2
  • 5
    • 0030733797 scopus 로고    scopus 로고
    • Phytochemistry of the genus Piper
    • Parmar VS et al. Phytochemistry of the genus Piper. Phytochemistry 1997; 46: 597-673.
    • (1997) Phytochemistry , vol.46 , pp. 597-673
    • Parmar, V.S.1
  • 6
    • 0037358585 scopus 로고    scopus 로고
    • Anti-inflammatory activity of Chinese medicinal vine plants
    • Li RW et al. Anti-inflammatory activity of Chinese medicinal vine plants. J Ethnopharmacol 2003; 85: 61-67.
    • (2003) J Ethnopharmacol , vol.85 , pp. 61-67
    • Li, R.W.1
  • 7
    • 59949090071 scopus 로고    scopus 로고
    • Chemical characterization of seven Piper species (Piperaceae) from Federal District, Brazil, based on volatile constituents
    • Potzernheim M et al. Chemical characterization of seven Piper species (Piperaceae) from Federal District, Brazil, based on volatile constituents. Braz J Med Plants 2006; 8: 10-12.
    • (2006) Braz J Med Plants , vol.8 , pp. 10-12
    • Potzernheim, M.1
  • 8
    • 0035047880 scopus 로고    scopus 로고
    • Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro
    • Stöhr JR et al. Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro. J Ethnopharmacol 2001; 75: 133-139
    • (2001) J Ethnopharmacol , vol.75 , pp. 133-139
    • Stöhr, J.R.1
  • 9
    • 0034736043 scopus 로고    scopus 로고
    • Antifungal amides from Piper hispidum and Piper tuberculatum
    • Navickiene HM et al. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 2000; 55: 621-626.
    • (2000) Phytochemistry , vol.55 , pp. 621-626
    • Navickiene, H.M.1
  • 12
    • 0033120565 scopus 로고    scopus 로고
    • Araújo-Júnior JX et al. Cepharanone B from Piper tuberculatum. Biochem. Sys Ecol 1999; 27: 325-327.
    • Araújo-Júnior JX et al. Cepharanone B from Piper tuberculatum. Biochem. Sys Ecol 1999; 27: 325-327.
  • 13
  • 14
    • 0002613424 scopus 로고
    • Piplartine-dimer A, a new alkaloid from Piper tuberculatum
    • Braz-Filho R et al. Piplartine-dimer A, a new alkaloid from Piper tuberculatum. Phytochemistry 1981; 20: 345-346.
    • (1981) Phytochemistry , vol.20 , pp. 345-346
    • Braz-Filho, R.1
  • 15
    • 0011290556 scopus 로고
    • Lignans from Piper genus (Piperaceae) and their bioactivity
    • Wu QL, Feng YX. Lignans from Piper genus (Piperaceae) and their bioactivity. World Notes on Plant Medicine 1994; 9: 51-56.
    • (1994) World Notes on Plant Medicine , vol.9 , pp. 51-56
    • Wu, Q.L.1    Feng, Y.X.2
  • 16
    • 0025604516 scopus 로고
    • Cytotoxic pyridone alkaloids from the leaves of Piper aborescens
    • Duh CY et al. Cytotoxic pyridone alkaloids from the leaves of Piper aborescens. J Nat Prod 1990; 53: 1575-1577.
    • (1990) J Nat Prod , vol.53 , pp. 1575-1577
    • Duh, C.Y.1
  • 17
    • 0030879255 scopus 로고    scopus 로고
    • Piperbetol, methylpiuperbetol, piperol A, piperol B: A new series of highly specific PAF receptor antagonists from Piper betle
    • Zeng HW et al. Piperbetol, methylpiuperbetol, piperol A, piperol B: a new series of highly specific PAF receptor antagonists from Piper betle. Planta Med 1997; 63: 296-298.
    • (1997) Planta Med , vol.63 , pp. 296-298
    • Zeng, H.W.1
  • 18
    • 24344452031 scopus 로고    scopus 로고
    • Antiproliferative effects of two amides, piperine and piplartine from Piper species
    • Bezerra DP et al. Antiproliferative effects of two amides, piperine and piplartine from Piper species. Z Naturforsch [C] 2005; 60: 539-543.
    • (2005) Z Naturforsch [C] , vol.60 , pp. 539-543
    • Bezerra, D.P.1
  • 19
    • 12944319340 scopus 로고    scopus 로고
    • Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants
    • Jatan I et al. Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomedicine 2005; 12: 88-92.
    • (2005) Phytomedicine , vol.12 , pp. 88-92
    • Jatan, I.1
  • 20
    • 21344469115 scopus 로고    scopus 로고
    • New cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens
    • Tsai IL et al. New cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Planta Med 2005; 71: 535-542.
    • (2005) Planta Med , vol.71 , pp. 535-542
    • Tsai, I.L.1
  • 21
    • 0242669344 scopus 로고    scopus 로고
    • Antioxidant and antiplatelet effects of aqueous inflorescence Piper betle extract
    • Lei D et al. Antioxidant and antiplatelet effects of aqueous inflorescence Piper betle extract. J Agric Food Chem 2003; 51: 2083-2088.
    • (2003) J Agric Food Chem , vol.51 , pp. 2083-2088
    • Lei, D.1
  • 22
    • 0036570004 scopus 로고    scopus 로고
    • Modulation of platelet aggregation by areca nut and betel leaf ingredients: Roles of oxygen species and cyclooxygenase
    • Jeng JH et al. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of oxygen species and cyclooxygenase. Free Radic Biol Med 2002; 32: 860-871.
    • (2002) Free Radic Biol Med , vol.32 , pp. 860-871
    • Jeng, J.H.1
  • 23
    • 0016500338 scopus 로고
    • The chemistry of Indian Piper species
    • Atal CK et al. The chemistry of Indian Piper species. Lloydia 1975; 38: 256-264.
    • (1975) Lloydia , vol.38 , pp. 256-264
    • Atal, C.K.1
  • 24
    • 0000369584 scopus 로고
    • Morphology and enumeration of human blood platelets
    • Brecher G, Cronkite EP. Morphology and enumeration of human blood platelets. J Appl Physiol 1950; 3: 365-372.
    • (1950) J Appl Physiol , vol.3 , pp. 365-372
    • Brecher, G.1    Cronkite, E.P.2
  • 25
    • 78651139188 scopus 로고
    • The aggregation of blood platelets
    • Born GVR, Cross MJ. The aggregation of blood platelets. J Physiol 1963; 168: 178-195.
    • (1963) J Physiol , vol.168 , pp. 178-195
    • Born, G.V.R.1    Cross, M.J.2
  • 26
    • 0025314048 scopus 로고
    • Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: Inhibition of cyclic AMP breakdown by cyclic GMP
    • Maurice DH, Haslam RJ. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 1990; 37: 671-681.
    • (1990) Mol Pharmacol , vol.37 , pp. 671-681
    • Maurice, D.H.1    Haslam, R.J.2
  • 27
    • 0032758199 scopus 로고    scopus 로고
    • Antithrombotic activities of green tea catechins and (2)-epigallocatechin gallate
    • Kang WS et al. Antithrombotic activities of green tea catechins and (2)-epigallocatechin gallate. Thromb Res 1999; 96: 229-237.
    • (1999) Thromb Res , vol.96 , pp. 229-237
    • Kang, W.S.1
  • 28
    • 0035877749 scopus 로고    scopus 로고
    • Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib
    • Soslau G et al. Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib. J Biol Chem 2001; 276: 21173-21183.
    • (2001) J Biol Chem , vol.276 , pp. 21173-21183
    • Soslau, G.1
  • 29
    • 18044385155 scopus 로고    scopus 로고
    • The P2 receptors in platelet function
    • Hechler B et al. The P2 receptors in platelet function. Semin Thromb Haemost 2005; 31: 150-161.
    • (2005) Semin Thromb Haemost , vol.31 , pp. 150-161
    • Hechler, B.1
  • 30
    • 33645282277 scopus 로고    scopus 로고
    • The platelet P2 receptors in arterial thrombosis
    • Gachet C et al. The platelet P2 receptors in arterial thrombosis. Blood Cells Mol Dis 2006; 36: 223-227.
    • (2006) Blood Cells Mol Dis , vol.36 , pp. 223-227
    • Gachet, C.1
  • 31
    • 0032488890 scopus 로고    scopus 로고
    • Role of P2Y1 purinoceptor in ADP-induced platelet activation
    • Savi P et al. Role of P2Y1 purinoceptor in ADP-induced platelet activation. FEBS Lett 1998; 422: 291-295.
    • (1998) FEBS Lett , vol.422 , pp. 291-295
    • Savi, P.1
  • 32
    • 0042703242 scopus 로고    scopus 로고
    • Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis
    • Conley PB, Delaney SM. Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis. Curr Opin Hematol 2003; 10: 333-338.
    • (2003) Curr Opin Hematol , vol.10 , pp. 333-338
    • Conley, P.B.1    Delaney, S.M.2
  • 33
    • 32844461118 scopus 로고    scopus 로고
    • The role of ADP receptors in platelet function
    • Murugappa S, Kunapuli SP. The role of ADP receptors in platelet function. Front Biosc 2006; 11: 1977-1986.
    • (2006) Front Biosc , vol.11 , pp. 1977-1986
    • Murugappa, S.1    Kunapuli, S.P.2
  • 34
    • 0034323126 scopus 로고    scopus 로고
    • Platelets from a patient heterozygous for the defect of P2CYC receptors forADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors
    • Cattaneo M et al. Platelets from a patient heterozygous for the defect of P2CYC receptors forADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors. Arterioscler Thromb Vasc Biol 2000; 20: E101-E106.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20
    • Cattaneo, M.1
  • 35
    • 0030273915 scopus 로고    scopus 로고
    • Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets
    • Ohkubo S et al. Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets. Prostaglandins 1996; 52: 403-413
    • (1996) Prostaglandins , vol.52 , pp. 403-413
    • Ohkubo, S.1
  • 36
    • 0023645277 scopus 로고
    • Heme spin states and peroxide induced radical species in prostaglandin H synthase
    • Kulmacs RS et al. Heme spin states and peroxide induced radical species in prostaglandin H synthase. J Biol Chem 1987; 262: 10524-10531.
    • (1987) J Biol Chem , vol.262 , pp. 10524-10531
    • Kulmacs, R.S.1
  • 37
    • 0026572664 scopus 로고
    • 2-dependent platelet activation
    • 2-dependent platelet activation. Platelets 1992; 2: 87-90.
    • (1992) Platelets , vol.2 , pp. 87-90
    • Iuliano, L.1
  • 38
    • 0021868379 scopus 로고
    • Hydrogen peroxide has a role in the aggregation of human platelets
    • Del Príncipe D et al. Hydrogen peroxide has a role in the aggregation of human platelets. FEBS Lett 1985; 185: 142-146.
    • (1985) FEBS Lett , vol.185 , pp. 142-146
    • Del Príncipe, D.1
  • 39
    • 0017540523 scopus 로고
    • Mechanism of platelet shape change, aggregation and release induced by collage, thrombin or A23187
    • Kimlough-Rathbone RL et al. Mechanism of platelet shape change, aggregation and release induced by collage, thrombin or A23187. J Lab Clin Med 1977; 90: 707-712.
    • (1977) J Lab Clin Med , vol.90 , pp. 707-712
    • Kimlough-Rathbone, R.L.1
  • 40
    • 0031962580 scopus 로고    scopus 로고
    • Hydrogen peroxide is involved in collagen-induced platelet activation
    • Pignatelli P et al. Hydrogen peroxide is involved in collagen-induced platelet activation. Blood 1998; 91: 484-490.
    • (1998) Blood , vol.91 , pp. 484-490
    • Pignatelli, P.1
  • 41
    • 0001145160 scopus 로고    scopus 로고
    • Superoxide anion and hydroxy radical release by collagen-induced platelet aggregation: Role of arachidonic acid metabolism
    • Caccese D et al. Superoxide anion and hydroxy radical release by collagen-induced platelet aggregation: role of arachidonic acid metabolism. Thromb Haemost 2000; 83: 485-490.
    • (2000) Thromb Haemost , vol.83 , pp. 485-490
    • Caccese, D.1
  • 42
    • 52649092888 scopus 로고    scopus 로고
    • Antiplatelet activities of newly synthesized derivatives of piperlongumine
    • Park BS et al. Antiplatelet activities of newly synthesized derivatives of piperlongumine. Phytother Res 2008; 22: 1195-1199.
    • (2008) Phytother Res , vol.22 , pp. 1195-1199
    • Park, B.S.1
  • 43
    • 34547849622 scopus 로고    scopus 로고
    • Piperlongumine, a constituent of Piper longumL., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist
    • IwashitaM
    • IwashitaMet al. Piperlongumine, a constituent of Piper longumL., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist. Eur J Pharmacol 2007; 570: 38-42.
    • (2007) Eur J Pharmacol , vol.570 , pp. 38-42


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.