New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens

Planta Medica

Volumn 71, Issue 6, 2005, Pages 535-542

  Tsai, Ian Lih ^a   Lee, Fan Pin ^a   Wu, Chin Chung ^a   Duh, Chang Yih ^b   Ishikawa, Tsutomu ^c   Chen, Jih Jung ^d   Chen, Yu Chang ^a   Seki, Hiroko ^c   Chen, Ih Sheng ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c CHIBA UNIVERSITY   (Japan)

^d TAJEN INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

(+) arborone; Anti platelet aggregation activity; Cyclobutanoid amides; Cytotoxicity; Furanoid lignan; Piper arborescens; Piperaceae; Piperarborenine; Stem

Indexed keywords

1,2,3 TRIMETHOXY 4,5 DIOXO 6A,7 DEHYDROAPORPHINE; 5,6 DIHYDRO 2(1H) PYRIDONE; ACETYLSALICYLIC ACID; AMIDE; ANTITHROMBOCYTIC AGENT; ARBORONE; ARISTOLACTAM B3; CEPHARADIONE B; CEPHARANONE B; COLLAGEN; DIAYANGAMBIN; GONIOTHALACTAM; LIGNAN DERIVATIVE; METHYL 3,4,5 TRIMETHOXYCINNAMATE; MITHRAMYCIN; PIPERARBORENINE A; PIPERARBORENINE B; PIPERARBORENINE C; PIPERARBORENINE D; PIPERARBORENINE E; PIPERARBORESINE; PIPEROLACTAM B; PIPEROLACTAM C; PIPLARTINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HT29; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA P 388; MOUSE; NONHUMAN; PIPERACEAE; SPECTROSCOPY; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LIGNANS; MICE; PHYTOTHERAPY; PIPER; PLANT EXTRACTS; PLANT STEMS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS;

PIPER ARBORESCENS; PIPERACEAE;

EID: 21344469115     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-864155     Document Type: Article

References (20)

1. Lin TT, Lu SY. Piperaceae in Flora of Taiwan; 2nd edition; Vol. 2 Editorial Committee of the Flora of Taiwan, Taipei, Taiwan: 1996: pp 624-31
2. Shin MH, Ph.D. Thesis. National Tsing Hua University, Hsinchu, Taiwan: 1991: p 10
3. Duh CY, Wu YC, Wang SK. Cytotoxic pyridone alkaloids from Piper arborescens. Phytochemistry 1990; 29: 2689-91
4. Duh CY, Wu YC, Wang SK. Cytotoxic pyridone alkaloids from the leaves of Piper arborescens. J Nat Prod 1990; 53: 1575-7
5. Lee FP, Chen YC, Chen JJ, Tsai IL, Chen IS. Cyclobutanoid amides from Piper arborescens. Helv Chim Acta 2004; 87: 463-8
6. Teng CM, Chen WY, Ko WC, Ouyang C. Antiplatelet effect of butylide-nephthalide. Biochim Biophys Acta 1987; 924: 375-82
7. O'Brien JR. Platelet aggregation II. Some results from a new method of study. J Clin Path 1962; 15: 452-5
8. Tsai IL, Lin WY, Teng CM, Ishikawa T, Doong SL, Huang MW, Chen YC, Chen IS. Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium. Planta Med 2000; 66: 618-23
9. Montaudo G, Caccamese S. Structure and conformation of chalcone photodimers and related compounds. J Org Chem 1973; 38: 710-6
10. Barnerji A, Sarkar M, Ghosal T, Pal SC, Shoolery JN. Sylvone, a new furanoid lignan of Piper sylvaticum. Tetrahedron 1984; 40: 5047-52
11. Chen IS, Chen JJ, Duh CY, Tsai IL. Cytotoxic lignans from Formosan Hernandia nymphaeifolia. Phytochemistry 1997; 45: 991-6
12. MacRae WD, Neil Towers GH. Non-alkaloidal constituents of Virola elongata bark. Phytochemistry 1985; 24: 561-6
13. Joshi BS, Kamat VN, Saksena AK. On the structure of piplartine and a synthesis of dihydropiplartine. Tetrahedron Lett 1968; 20: 2395-400
14. Desai SJ, Prabhu BR, Mulchandani NB. Aristolactams and 4,5-dioxoaporphines from Piper longum. Phytochemistry 1988; 27: 1511-5
15. Mahmood K, Chan KC, Park MH, Han YN, Han BH. An aporphinoid alkaloid from Pseuduvaria macrophylla. Phytochemistry 1986; 25: 1509-10
16. Olsen CE, Tyagi OD, Boll PM, Hussaini FA, Parmar VS, Sharma NK, Taneja P, Jain SC. An aristolactam from Piper acutisleginum and revision of the structures of piperolactam B and D. Phytochemistry 1993; 33: 518-20
17. Lo WL, Chang FR, Wu YC. Alkaloids from the leaves of Fissistigma glaucescens.J Chin Chem Soc 2000; 47: 1251-6
18. Cao SG, Wu XH, Sim KY, Tan BKH, Pereira JT, Goh SH. Styryl-lactone derivatives and alkaloids from Goniothalamus borneensis (Annonaceae). Tetrahedron 1998; 54: 2143-8
19. Dutta CP, Banerjee N, Sil AK, Roy DN. Studies on the genus Piper: studies on the roots of Piper longum Linn. Indian J Chem Sec B 1977; 15: 583-4
20. Chia YC, Chang FR, Teng CM, Wu YC. Aristolactam and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. J Nat Prod 2000; 63: 1160-3