Synthesis, and cytotoxic activity of some novel indolo[2,3-b]quinoline derivatives: DNA topoisomerase II inhibitors

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 11, 1999, Pages 2457-2464

  Kaczmarek, Łukasz ^a   Peczyńska Czoch, Wanda ^b   Osiadacz, Jarosław ^c   Mordarski, Marian ^c   Sokalski, W Andrzej ^d   Boratyński, Janusz ^c   Marcinkowska, Ewa ^c   Glazman Kuśnierczyk, Halina ^c   Radzikowski, Czesław ^c  

^a INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

^b UNIVERSITY OF WROC AW   (Poland)

^c INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^d WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Cytotoxic agents; Indolo 2,3 b quinolines; Quantum chemical calculations; Topoisomerase II inhibitors

Indexed keywords

GYRASE INHIBITOR; QUINOLINE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DNA BINDING; DRUG SYNTHESIS; FUNGUS; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR BIOLOGY; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; DNA; DNA TOPOISOMERASES, TYPE II; HL-60 CELLS; HUMANS; INDOLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

BACTERIA (MICROORGANISMS); FUNGI; POSIBACTERIA;

EID: 0342632803     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00200-X     Document Type: Article

References (17)

1. Kaczmarek Ł, Balicki R., Nantka-Namirski P., Peczy-ska-Czoch W., Mordarski M. Arch. Pharm. (Weinheim). 321:1988;463.
2. Pognan F., Saucier J.M., Paoletti C., Kaczmarek Ł, Nantka-Namirski P., Mordarski M., Peczyńska-Czoch W. Biochem. Pharmacol. 44:1992;2149.
3. Peczyńska-Czoch W., Pognan F., Kaczmarek Ł, Boratyñski J. J. Med. Chem. 37:1994;3503.
4. McGhee J.D., Von Hippel P.H. J. Mol. Biol. 86:1974;469.
5. Osiadacz, J.; Peczyñska-Czoch, W.; Kaczmarek, Ł.; Opolski, A. 6th International Symposium on Molecular Aspects of Chemotherapy 9-12 July 1997, Gdañsk, Poland.
6. Naray-Szabo G., Ferenczy G.G. Chem. Rev. 95:1995;829.
7. Price S.L., LoCelso F., Treichel J.A., Goodfellow J.M., Umrania Y. J. Chem. Soc. Faraday Trans. 89:1993;3407.
8. Price S.L., Stone A.J. J. Chem. Phys. 86:1987;2859.
9. Sokalski W.A., Poirier R. Chem. Phys. Lett. 98:1983;86.
10. Sokalski W.A., Sawaryn A. J. Chem. Phys. 87:1987;526.
11. Campbell K.N., Tipson S.R., Elderfield R.C., Campbell B.K., Clapp M.A., Gensler W.J., Morisson D., Moran W.J. J. Org. Chem. 11:1946;803.
12. Kaslow, C. E.; Laver, W. M. Org. Synt. Coll. 3, 194.
13. Holt, S. J.; Petrov, V. J. Chem. Soc. 1948, 922.
14. Cory M., McKee D.D., Kagan J., Henry D.W., Miller A.J. J. Am. Chem. Soc. 107:1985;2528.
15. Approved standard M7-A2, In National Committee for Clinical Laboratory Standards, 2nd ed.; Villanova, PA, 1990.
16. Frish; M. J.; Trucks; G. W.; Schlegel; H. B.; Gill; P. M. W.; Johnson; B. G.; Robb; M. A.; Cheesman; J. R.; Keith; T. A.; Petersson; G. A.; Montgomery; J. A.; Raghavachari; K.; Al. -Laham; M. A.; Zakrzewski; V. G.; Ortiz; J. V.; Foresman; J. B.; Cioslowski; J.; Stefanov; B. B.; Nanayakkara; A.; Challacombe; M.; Peng; C. Y.; Ayala; P. Y.; Chen; W.; Wong; M. W.; Andres; J. L.; Replogle; E. S.; Gomperts; R.; Martin; R. L.; Fox; D. J.; Binkley; J. S.; Defrees; D. J.; Baker; J.; Stewart; J. P.; Head-Gordon; M.; Gonzales; C.; Pople; J. A. Gaussian 94 (Revision 3. 1), Gaussian, Inc., Pittsburgh, PA
17. Sokalski W.A., Sneddon S. J. Mol. Graphics. 9:1991;86.