Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives

Journal of Medicinal Chemistry

Volumn 52, Issue 9, 2009, Pages 2979-2988

  El Sayed, Ibrahim ^a   Van Der Veken, Pieter ^a   Steert, Koen ^a   Dhooghe, Liene ^a   Hostyn, Steven ^a   Van Baelen, Gitte ^a   Lemière, Guy ^a   Maes, Bert U W ^a   Cos, Paul ^a   Maes, Louis ^a   Joossens, Jurgen ^a   Haemers, Achiel ^a   Pieters, Luc ^a   Augustyns, Koen ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CRYPTOLEPINE DERIVATIVE; N1,N1 DIETHYL N4 (5 METHYL 5H INDOLO[2,3 B]QUINOLIN 3 YL)PENTANE 1,4 DIAMINE; N1,N1 DIETHYL N4 (5 METHYL 5H INDOLO[2,3 B]QUINOLIN 8 YL)PENTANE 1,4 DIAMINE; N4 (2 CHLORO 5 METHYL 5H INDOLO[2,3 B]QUINOLIN 11 YL) N1,N1 DIETHYLPENTANE 1,4 DIAMINE; N4 (2 CHLORO 6H INDOLO[2,3 B]QUINOLIN 11 YL) N1,N1 DIETHYLPENTANE 1,4 DIAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI;

ALKALOIDS; ANIMALS; ANTIMALARIALS; DNA, PROTOZOAN; DRUG DESIGN; MICE; PLASMODIUM FALCIPARUM; QUINOLINES;

EID: 65649114459     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801490z     Document Type: Article

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