Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

Epilepsia

Volumn 53, Issue 7, 2012, Pages 1254-1263

  Van Vliet, Erwin A ^a,b   Forte, Grazia ^a   Holtman, Linda ^a   Den Burger, Jeroen C G ^c   Sinjewel, Arno ^c   De Vries, Helga E ^c   Aronica, Eleonora ^d   Gorter, Jan A ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Blood brain barrier; Gliosis; Inflammation; Status epilepticus; Temporal lobe epilepsy

Indexed keywords

CD11B ANTIGEN; CD68 ANTIGEN; GLYCOPROTEIN P 15095; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL ACTIVATION; CELL LOSS; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; DRUG MECHANISM; ELECTROENCEPHALOGRAPHY; ELECTROSTIMULATION; ENCEPHALITIS; EPILEPTIC STATE; EPILEPTOGENESIS; MALE; MICROGLIA; NERVE CELL NECROSIS; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11B; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BLOOD-BRAIN BARRIER; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; IMMUNOSUPPRESSIVE AGENTS; MALE; MICROGLIA; MONOCYTES; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SIGNAL TRANSDUCTION; SIROLIMUS; STATISTICS AS TOPIC; STATISTICS, NONPARAMETRIC; STATUS EPILEPTICUS; TIME FACTORS; TOR SERINE-THREONINE KINASES; VIMENTIN;

EID: 84863718111     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2012.03513.x     Document Type: Article

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